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Malaria disease and modern treatments
Some population groups are at considerably higher risk of contracting malaria and developing severe disease: infants, children under 5 years of age, pregnant women and patients with HIV/AIDS, as well as people with low immunity moving to areas with intense malaria transmission such as migrant workers, mobile populations and travellers. Malaria is an acute febrile illness caused by Plasmodium parasites, which are spread to people through the bites of infected female Anopheles mosquitoes. There are 5 parasite species that cause malaria in humans, and 2 of these species – P. falciparum and P. vivax – pose the greatest threat. P. falciparum is the deadliest malaria parasite and the most prevalent on the African continent. P. vivax is the dominant malaria parasite in most countries outside of sub-Saharan Africa.
Malaria : Genetic and Evolutionary Aspects
This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane’s contribution from two directions: (a) it has been suggested that the “Malaria Hypothesis” was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004).
Making Ammonia : Fritz Haber, Walther Nernst, and the Nature of Scientific Discovery
This book discusses the progress of science and the transfer of scientific knowledge to technological application. It also identifies the factors necessary to achieve this progress. Based on a case study of the physical chemist Fritz Haber's discovery of ammonia synthesis between 1903 and 1909, the book places Haber's work in historical and scientific (physicochemical) context. The scientific developments of the preceding century are framed in a way that emphasizes the confluence of knowledge needed for Haber's success. Against this background, Haber's work is presented in detail along with the indispensable contributions of his colleague, the physical chemist, Walter Nernst, and their assistants. The detailed accounts of scientific advancement remind us of the physical basis on which our scientific theories and ideas are built. Without this reminder we often forget how complex, and how beautiful achievements in science can be.
Make and Test Projects in Engineering Design : Creativity, Engagement and Learning
This is a book about the invention and testing of ideas. By describing how to generate engaging problem situations for engineering students to solve it inspires original currents of thought. This is the first book that formalises an important aspect of early learning in engineering design.
Maintenance of brick and stone masonry structures
Deals with all the tasks related to brick and stone masonry structures, from the initial identification of defects and their diagnosis to their treatment and monitoring of its cost-effectiveness.
Magnetohydrodynamics : Historical Evolution and Trends
Magnetohydrodynamics (MHD) studies the interaction between the flow of an electrically conducting fluid and magnetic fields. It involves such diverse topics as the evolution and dynamics of astrophysical objects, thermonuclear fusion, metallurgy and semiconductor crystal growth, etc. Although the first ideas in magnetohydrodynamics appeared at the beginning of the last century, the "explosion" in theoretical and experimental studies occurred in the 1950s-60s. This state-of-the-art book aims at revising the evolution of ideas in various branches of magnetohydrodynamics (astrophysics, earth and solar dynamos, plasmas, MHD turbulence and liquid metals) and reviews current trends and challenges.
Magnetic Monopoles
This monograph addresses the field theoretical aspects of magnetic monopoles. Written for graduate students as well as researchers, the author demonstrates the interplay between mathematics and physics. He delves into details as necessary and develops many techniques that find applications in modern theoretical physics. This introduction to the basic ideas used for the description and construction of monopoles is also the first coherent presentation of the concept of magnetic monopoles. It arises in many different contexts in modern theoretical physics, from classical mechanics and electrodynamics to multidimensional branes. The book summarizes the present status of the theory and gives an extensive but carefully selected bibliography on the subject. The first part deals with the Dirac monopole, followed in part two by the monopole in non-abelian gauge theories. The third part is devoted to monopoles in supersymmetric Yang-Mills theories.
Machine learning refined : Foundations, algorithms, and applications
Providing a unique approach to machine learning, this text contains fresh and intuitive, yet rigorous, descriptions of all fundamental concepts necessary to conduct research, build products, tinker, and play. By prioritizing geometric intuition, algorithmic thinking, and practical real world applications in disciplines including computer vision, natural language processing, economics, neuroscience, recommender systems, physics, and biology, this text provides readers with both a lucid understanding of foundational material as well as the practical tools needed to solve real-world problems. With in-depth Python and MATLAB/OCTAVE-based computational exercises and a complete treatment of cutting edge numerical optimization techniques, this is an essential resource for students and an ideal reference for researchers and practitioners working in machine learning, computer science, electrical engineering, signal processing, and numerical optimization
Machine Learning and Knowledge Extraction ; 5th IFIP TC 5, TC 12, WG 8.4, WG 8.9, WG 12.9 International Cross-Domain Conference, CD-MAKE 2021, Virtual Event, August 17–20, 2021, Proceedings
Constitutes the refereed proceedings of the 5th IFIP TC 5, TC 12, WG 8.4, WG 8.9, WG 12.9 International Cross-Domain Conference, CD-MAKE 2021, held in virtually in August 2021. The 20 full papers and 2 short papers presented were carefully reviewed and selected from 48 submissions. The cross-domain integration and appraisal of different fields provides an atmosphere to foster different perspectives and opinions; it will offer a platform for novel ideas and a fresh look on the methodologies to put these ideas into business for the benefit of humanity.
Machine Learning and Data Mining in Pattern Recognition ; 4th International Conference, MLDM 2005, Leipzig, Germany, July 9-11, 2005, Proceedings
Today, artificial intelligence deals with large amounts of data and knowledge and finds new information using machine learning and data mining. Machine learning and data mining are irreplaceable subjects and tools for the theory of pattern recognition and in applications of pattern recognition such as bioinformatics and data retrieval. This was the fourth edition of MLDM in Pattern Recognition which is the main event of Technical Committee 17 of the International Association for Pattern Recognition; it started out as a workshop and continued as a conference in 2003. Today, there are many international meetings which are titled “machine learning” and “data mining”, whose topics are text mining, knowledge discovery, and applications. This meeting from the first focused on aspects of machine learning and data mining in pattern recognition problems. We planned to reorganize classical and well-established pattern recognition paradigms from the viewpoints of machine learning and data mining. Though it was a challenging program in the late 1990s, the idea has inspired new starting points in pattern recognition and effects in other areas such as cognitive computer vision.
Machine Learning Algorithms Using Python Programming
Presents the key concepts of Machine Learning which includes Python concepts and Interpreter, Foundation of Machine Learning, Data Pre-processing, Supervised Machine Learning, Unsupervised Machine Learning, Reinforcement Learning, Kernel Machine, Design and analysis of Machine Learning experiment and Data visualization. The theoretical concepts along with coding implementation are covered. This book aims to pursue a middle ground between a theoretical textbook and one that focuses on applications. The book concentrates on the important ideas in machine learning.
Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Lymphocyte Signal Transduction
Signal transduction through leukocyte receptors involves a variety of signaling molecules including kinases, phosphatases, adaptor proteins, small GTPases GTP exchange factors, membrane phospholipids as well as others. These signal transducers, regulated by inter- and intra-molecular interactions, as well as by various post-translational modifications, lead to the activation of transcription factors that mediate cellular differentiation and growth, effector cell functions, and apoptotic cell death. Several investigators from various parts of the world convened at the 3rd Lymphocyte Signal Transduction Workshop in Crete, Greece from May 27 to June 1, 2005 to discuss their most recent findings in leukocyte signaling. This volume represents a collection of topics discussed during the conference.
Lung cancer : causes, diagnosis, treatment
Lung cancer remains the leading cause of cancer-related deaths in the United States and the world - responsible for approximately 1.8 million deaths annually Lung cancer is still expected to cause more than 4 million deaths over the next 50 years. Thus, in addition to tobacco control efforts, a focus on early detection and treatment interventions will be critical to further reducing the burden of lung cancer...
Low-Temperature Physics
This book provides a concise but thorough introduction to important phenomena of low-temperature physics. It is ideally suited as a textbook for advanced undergraduates but will also be valuable for graduate students, scientists and engineers working in this field. Clear explanations of both theoretical and experimental approaches coupled with carefully selected problems will enable students to gain a firm understanding of even the most recent research developments.
Low Power Uwb Cmos Radar Sensors
Low Power UWB CMOS Radar Sensors deals with the problem of designing low cost CMOS radar sensors. The radar sensor uses UWB signals in order to obtain a reasonable target separation capability, while maintaining a maximum signal frequency below 2 GHz. This maximum frequency value is well within the reach of current CMOS technologies. The use of UWB signals means that most of the methodologies used in the design of circuits and systems that process narrow band signals, can no longer be applied. Low Power UWB CMOS Radar Sensors provides an analysis between the interaction of UWB signals, the antennas and the processing circuits.
Lost Causes in and beyond Physics
Lost Causes in and Beyond Physics deals with a selection of research topics mostly from theoretical physics that have been shown to be a dead-end or continue at least to be highly controversial. This book is written as both an entertainment and serious study and should be accessible to anyone with a background in theoretical physics and mathematics.
Loop Spaces, Characteristic Classes and Geometric Quantization
This book deals with the differential geometry of manifolds, loop spaces, line bundles and groupoids, and the relations of this geometry to mathematical physics. Various developments in mathematical physics (e.g., in knot theory, gauge theory, and topological quantum field theory) have led mathematicians and physicists to search for new geometric structures on manifolds and to seek a synthesis of ideas from geometry, topology and category theory. In this spirit, this book develops the differential geometry associated to the topology and obstruction theory of certain fiber bundles (more precisely, associated to grebes). The theory is a 3-dimensional analog of the familiar Kostant--Weil theory of line bundles. In particular the curvature now becomes a 3-form.
Logos of Phenomenology and Phenomenology of the Logos. Book One : Phenomenology as the Critique of Reason in Contemporary Criticism and Interpretation
During its century-long unfolding, spreading in numerous directions, Husserlian phenomenology while loosening inner articulations, has nevertheless maintained a somewhat consistent profile. As we see in this collection, the numerous conceptions and theories advanced in the various phases of reinterpretations have remained identifiable with phenomenology.
Logistics Systems Analysis
It has two new sections, a new appendix, and more than half a dozen new figures. A few references have also been added, Much of the new material is based on work , The financial support of the National Science Foundation and the Volvo Foundations Center of Excellence for the Future of Urban Transportation at U. C. Berkeley is also acknowledged. The new appendix presents the logic behind the traveling salesman and vehicle routing results used in Sec. 4. 2 to describe the transportation ope- tion; Chapter 4 is more self-contained as a result. New section 5. 6 int- duces and evaluates a general method that automatically translates the c- tinuum approximation recipes of Chapters 4 and 5 into discrete system designs. This closes a gap in previous editions. Other additions include an explanation of how to develop system designs that can efficiently acc- modate real-time control strategies to manage uncertainty (new section 4. 6. 3), and extensions of the many-to-many design ideas of Chap. 6
