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Parametric X-Ray Radiation in Crystals : Theory, Experiment and Applications
Devoted to parametric X-ray radiation (PXR). This radiation is generated by the motion of electrons inside a crystal, whereby the emitted photons are diffracted by the crystal and the radiation intensity critically depends on the parameters of the crystal structure. Nowadays PXR is the subject of numerous theoretical and experimental studies throughout the world. The first part of the book is a theoretical treatment of PXR, which includes a new approach to describe the radiation process in crystals. The second part is a survey of PXR experimental results and the possible applications of PXR as a tool for crystal structure analysis and a source of tunable X-ray radiation.
Parameter Setting in Evolutionary Algorithms
One of the main difficulties of applying an evolutionary algorithm (or, as a matter of fact, any heuristic method) to a given problem is to decide on an appropriate set of parameter values. Typically these are specified before the algorithm is run and include population size, selection rate, operator probabilities, not to mention the representation and the operators themselves. This book gives the reader a solid perspective on the different approaches that have been proposed to automate control of these parameters as well as understanding their interactions. The book covers a broad area of evolutionary computation, including genetic algorithms, evolution strategies, genetic programming, estimation of distribution algorithms, and also discusses the issues of specific parameters used in parallel implementations, multi-objective evolutionary algorithms, and practical consideration for real-world applications. It is a recommended read for researchers and practitioners of evolutionary computation and heuristic methods.
Parameter Estimation in Stochastic Differential Equations
Parameter estimation in stochastic differential equations and stochastic partial differential equations is the science, art and technology of modelling complex phenomena and making beautiful decisions. The subject has attracted researchers from several areas of mathematics and other related fields like economics and finance. This volume presents the estimation of the unknown parameters in the corresponding continuous models based on continuous and discrete observations and examines extensively maximum likelihood, minimum contrast and Bayesian methods. Useful because of the current availability of high frequency data is the study of refined asymptotic properties of several estimators when the observation time length is large and the observation time interval is small. Also space time white noise driven models, useful for spatial data, and more sophisticated non-Markovian and non-semimartingale models like fractional diffusions that model the long memory phenomena are examined in this volume.
Parallel and Distributed Processing and Applications - ISPA 2005 Workshops ; ISPA 2005 International Workshops, AEPP, ASTD, BIOS, GCIC, IADS, MASN, SGCA, and WISA, Nanjing, China, November 2-5, 2005, Proceedings
Welcome to the proceedings of the ISPA 2005 workshops, held in the city of Nanjing, China. For the first time eight workshops were held in conjunction with the 3rd International Symposium on Parallel and Distributed Processing and Applications (ISPA 2005), to encourage interaction between researchers and practitioners. Workshop topics are, of course, in line with the conference s scientific scope and the workshops provided a forum for groups of researchers and practitioners to meet together more closely, to exchange opinions and advanced ideas, and to share preliminary results on focused issues in an atmosphere that fostered interaction and problem solving.
Palladium in Organic Synthesis
Presents a number of accounts and reviews on the novel Pd-catalyzed reactions discovered mainly in the last five years. The book covers Pd-catalyzed reactions that are new – entirely different from the more standard ones. Topics such as new reactions involving ß-carbon elimination and formation of palladacycles as key reactions, cross-coupling of unactivated alkyl electrophiles with organometallic compounds, arylation via C-H bond cleavage, Pd/norbornene-catalyzed aromatic functionalizations, three-component cyclizations of allenes, use of N-heterocyclic carbenes as ligands, asymmetric reactions catalyzed by Pd(II) compounds such as Lewis acids, cycloadditions of arynes and alkynes, and nucleophilic attack by Pd species are surveyed in detail by researchers who have made important contributions to these fields. The book addresses graduate students majoring in organic synthesis and researchers in academic and industrial institutes.
Paclitaxel : Sources, Chemistry, Anticancer Actions, and Current Biotechnology
Provides a comprehensive survey of Paclitaxel and its derivatives chemistry, biosynthesis and anticancer activities. In addition, biotechnological methods, including cell cultures, the use of bioreactors and metabolic engineering strategies to improve Paclitaxel production are also discussed. The book discusses topics such as mechanisms of action against cancer, novel forms of Paclitaxel for an effective cancer treatment, strategies for enhancing its bioavailability, and the application of nanocarriers for its delivery and chemotherapy of cancer.
Oxidative Stress and Neuroprotection
This book deals with basic and clinical aspects of monoamine oxidase (MAO) subtypes A and B highlighting its importance in neurological and psychiatric diseases. Consequently the therapeutic actions of MAO-A and -B inhibitors in Parkinson’s disease (PK) and depression are the focus of several chapters. As MAO is the basis of the development of the "oxidative stress hypothesis" of PD, several chapters are devoted to iron and iron-induced oxidative stress in various experimental studies and clinical conditions. Based on these findings, new compounds have been developed which not only block MAO, but are in addition, either inhibitors of acetylcholine esterase or have iron chelating properties. The aspect of "preclinical" and "clinical" neuro protection as well as MAO neuroprotection are additional topics covered in this book. MAO, iron and neuroprotection are seen in the framework of general anti Parkinson’s therapy with chapters on levodopa, dopaminergic receptor agonists and clinical issues.
Oxidation of Alcohols to Aldehydes and Ketones : A Guide to Current Common Practice
This book is a must for anyone involved in the preparation of organic compounds. It is the first one in a new series on basic reactions in organic synthesis. It provides plenty of detailed and useful information in the practical aspects of the oxidation of alcohols to aldehydes and ketones, which is probably the most important reaction in the synthesis of organic compounds.
Oxidants in Biology : A Question of Balance
Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.
Outsourcing Legal Aid in the Nordic Welfare States
This edited collection provides a comprehensive analysis of the differences and similarities between civil legal aid schemes in the Nordic countries whilst outlining recent legal aid transformations in their respective welfare states. Based on in-depth studies of Norway, Sweden, Finland, Denmark, and Iceland, the authors compare these cases with legal aid in Europe and the US to examine whether a single, unique Nordic model exists. Contextualizing Nordic legal aid in relation to welfare ideology and human rights, Hammerslev and Halvorsen Rønning consider whether flaws in the welfare state exist, and how legal aid affects disadvantaged citizens.
Outer Magnetospheric Boundaries : Cluster Results
When the stream of plasma emitted from the Sun (the solar wind) encounters Earth's magnetic field, it slows down and flows around it, leaving behind a cavity, the magnetosphere. The magnetopause is the surface that separates the solar wind on the outside from the Earth's magnetic field on the inside. Because the solar wind moves at supersonic speed, a bow shock must form ahead of the magnetopause that acts to slow the solar wind to subsonic speeds. Magnetopause, bow shock and their environs are rich in exciting processes in collisionless plasmas, such as shock formation, magnetic reconnection, particle acceleration and wave-particle interactions. They are interesting in their own right, as part of Earth's environment, but also because they are prototypes of similar structures and phenomena that are ubiquitous in the universe, having the unique advantage that they are accessible to in situ measurements. The boundaries of the magnetosphere have been the target of direct in-situ measurements since the beginning of the space age. But because they are constantly moving, changing their orientation, and undergoing evolution, the interpretation of single-spacecraft measurements has been plagued by the fundamental inability of a single observer to unambiguously distinguish spatial from temporal changes. The boundaries are thus a prime target for the study by a closely spaced fleet of spacecraft. Thus the Cluster mission, with its four spacecraft in a three-dimensional configuration at variable separation distances, represents a giant step forward. The present 20th volume of the ISSI Space Science Series represents the first synthesis of the exciting new results obtained in the first few years of the Cluster mission.
Outdoor Learning and Play : Pedagogical Practices and Children's Cultural Formation
Examines children’s participation in dialectical reciprocity with place-based institutional practices by presenting empirical research from Australia, Brazil, China, Poland, Norway and Wales. Underpinned by cultural-historical theory, the analysis reveals how outdoors and nature form unique conditions for children's play, formal and informal learning and cultural formation. The analysis also surfaces how inequalities exist in societies and communities, which often limit and constrain families' and children's access to and participation in outdoor spaces and nature. The findings highlight how institutional practices are shaped by pedagogical content, teachers' training, institutional regulations and societal perceptions of nature, children and suitable, sustainable education for young children. Due to crises, such as climate change and the recent pandemic, specific focus on the outdoors and nature in cultural formation is timely for the cultural-historical theoretical tradition. In doing so, the book provides empirical and theoretical support for policy makers, researchers, educators and families to enhance, increase and sustain outdoor and nature education.
Organized Crime : Culture, Markets and Policies
Complex interactions of economic, technological, political, and cultural factors have fed the rise of criminal networks worldwide. At the same time, global illegal activities depend on a world of social realities to function. Organized Crime moves beyond traditional concepts of "evil forces" corrupting their host societies, instead analyzing local, national, and international manifestations of organized crime in the situational contexts that aid in its development. The contributors provide up-to-date understanding of various aspects of organized crime, in both classic areas of research (drugs, sex trafficking, labor racketeering) and emerging areas of interest (diamond smuggling, money laundering, eco-crime), in locales as varied as Italy, Quebec, the Sinai, Bulgaria, and the world’s tropical rain forests. Topics are explored from a variety of perspectives, including sociology, criminology, political science, and anthropology, giving this book empirical breadth and depth rarely seen in the literature.
Organizational Principles for Multi-Agent Architectures
Key topics of this book:- a framework for multi-agent system design, based on human organizational notions and principles for distributed intelligent systems design- "Coordination mechanisms" in the form of "Problem Solving Methods", which can assist "Managers" and agent engineers in reasoning about coordination- the "Five Capabilities (5C) model" which is a conceptual framework bases on a generalization of typical agent intelligence competences, such as "autonomy", "interaction", "pro-activeness" and "reactiveness"- a multi-agent architecture capable of (semi)automatic reuse of Problem Solving Methods- "ontology-based communication", in which the meaning and intention of message contents in agent communication is specified in "message content ontologies".
Organization Management – Dynamic Creative Team Coordination
Through an in-depth process study of the interactions of two creative groups (film production crew) in temporary organizations during two media projects, explores how a team developmental process unfolds and proposes a model illustrating how the groups repeatedly change formation so that individuals can manage job interdependencies and new issues arising while developing, building up, and synthesizing new ideas into a final creative solution. This theory on creative group dynamic coordination builds theory on how and why creative groups coordinate, challenges assumptions about the role of formal structures and informal practices by demonstrating how the two dynamically interact and complement each other to facilitate coordination via the emergence of what one would expect to be “un-coordinated methods”, and provides an alternative perspective to the stages the groups have to go through by emphasizing a cyclical and not a linear team developmental process.
Organic Solid State Reactions
Organic reactions in the absence of solvent, so called “Organic Solid-State Reactions”, have been well established as proceeding much more efficiently and faster than solution reactions in many cases, since solid-state reactions are infinitely high-concentration reactions. Organic solid-state reactions proceed even more selectively than solution reactions in some cases, since substrate molecules in solids or crystals are ordered regularly. Solid-state reactions are important not only for their high efficiency and selectivity but also for their simplicity and cleanness. In this volume, thermochemical and photochemical reactions in the solid state which have been studied mainly during the last five years by eight research groups are included. The editor hopes that this volume will contribute to the further development of organic solid-state reactions and solid-state chemistry.
Organic Redox Chemistry : Chemical, Photochemical and Electrochemical Syntheses
This book highlights electron transfer processes in synthesis by using different techniques to initiate them, allowing for a multi-directional perspective in organic redox chemistry. Covering a wide array of the important and recent developments in the field, Organic Redox Chemistry will earn a place in the libraries of chemists seeking a one-stop resource that compares chemical, photochemical, and electrochemical methods in organic synthesis.
Organic Chemistry ; 9th ed.
Structure and Bonding / Polar Covalent Bonds; Acids and Bases / Organic Compounds: Alkanes and Their Stereochemistry / Organic Compounds: Cycloalkanes and Their Stereochemistry / Stereochemistry at Tetrahedral Centers / An Overview of Organic Reactions / Alkenes: Structure and Reactivity / Alkenes: Reactions and Synthesis / Alkynes: An Introduction to Organic Synthesis / Organohalides / Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations / Structure Determination: Mass Spectrometry and Infrared Spectroscopy / Structure Determination: Nuclear Magnetic Resonance Spectroscopy / Conjugated Compounds and Ultraviolet Spectroscopy / Benzene and Aromaticity / Chemistry of Benzene: Electrophilic Aromatic Substitution / Alcohols and Phenols / Ethers and Epoxides; Thiols and Sulfides / Aldehydes and Ketones: Nucleophilic Addition Reactions / Carboxylic Acids and Nitriles / Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions / Carbonyl Alpha-Substitution Reactions / Carbonyl Condensation Reactions / Amines and Heterocycles / Biomolecules: Carbohydrates / Biomolecules: Amino Acids, Peptides, and Proteins / Biomolecules: Lipids / Biomolecules: Nucleic Acids / The Organic Chemistry of Metabolic PathwaysOrbitals and Organic Chemistry: Pericyclic Reactions Synthetic / Polymers
Organ on a chip for drug development and disease modeling
“Organ-on-a-chip” systems integrate microengineering, microfluidic technologies, and biomimetic principles to create key aspects of living organs faithfully, including critical microarchitecture, spatiotemporal cell–cell interactions, and extracellular microenvironments. This creative platform and its multiorgan integration recapitulating organ-level structures and functions can bring unprecedented benefits to a diversity of applications, such as developing human in vitro models for healthy or diseased organs, enabling the investigation of fundamental mechanisms in disease etiology and organogenesis, benefiting drug development in toxicity screening and target discovery, and potentially serving as replacements for animal testing.
Orbital Tumors : Diagnosis and Treatment
In order to provide the most recent developments in the science of orbitology, Orbital Tumors explores the latest developments in medical genetics, molecular genetics, and immunosurveillance mechanisms of neoplasia. The occurrence of multiple, malignant neoplasms in retinoblastoma have been included to apply molecular concepts to clinical practice related to orbital tumors. In the realm of clinical practice for orbital pathology, no development has been more influential than the revolution in imaging techniques, including ultrasonography, computerized tomography, and magnetic resonance methods. The implications of these improvements in diagnostic capabilities are fully explored and explained in Orbital Tumors. The text also includes diagnostic advances in immunohistochemistry, flow cytometry, gene microarray, and the polymerase chain reaction. These are summarized in a separate chapter on orbital biopsy.
