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Myosins : A Superfamily of Molecular Motors
Application of state-of-the-art cellular and molecular biological, structural biological, genetic, biochemical and biophysical techniques has provided and continues to provide critical information regarding the structure–function relationship; and the cellular roles of various myosins in organisms as diverse as protozoa, yeast, plants and higher animals. The association of myosins with diseases including neurological disorders, immu- deficiencies, cardiomyopathies, hearing and vision loss testify to the importance of understanding the biochemical properties and cellular roles of myosins. The 16 chapters in this volume summarize the tremendous progress made in studying members of the myosin superfamily in recent years and offer critical insight into what future research will yield.
Mutual Funds For Dummies
With straightforward advice and plenty of specific fund recommendations, Eric Tyson helps you avoid fund-investing pitfalls and maximize your returns. This new edition covers the latest investment trends and philosophies, including factor investing, ESG investing, and online investing.
Muscle hypertrophy and role of anabolic hormones in bodybuilding
The goal of our research first of all to give an overall view on the physiology of muscles and we will focus on natural elements such as diet and exercises to improve your aim without using chemical drugs, we will also include other factors affecting hypertrophy muscle such as genetic ones since the variation in between two sportive persons might be more than 50 percent determined by heredity which is a very important element and may lead a sportive man to elevate the doses to reach the same development of ideal muscles.
Multivariate Statistics : Exercises and Solutions
The first part is devoted to graphical techniques. The second part deals with multivariate random variables and presents the derivation of estimators and tests for various practical situations. The last part introduces a wide variety of exercises in applied multivariate data analysis. The book demonstrates the application of simple calculus and basic multivariate methods in real life situations. It contains altogether 234 solved exercises which can assist a university teacher in setting up a modern multivariate analysis course. All computer-based exercises are available in the R or XploRe languages.
Multivariate Statistical Machine Learning Methods for Genomic Prediction
This book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments.
Multiscale fatigue crack initiation and propagation of engineering materials ; Structural integrity and microstructural worthiness : Fatigue crack growth behaviour of small and large bodies
This book elucidates the correlation of fatigue crack growth data to multiscale cracking, particularly to the understanding of micrographs influenced by mechanical disturbance and thermodynamic variables. Attention is given to the interpretation of test data by fatigue crack growth rate using two empirical parameters in consistence with the fracture control methodology currently used by industry.
Multi-Scale Approaches in Drug Discovery : From Empirical Knowledge to In silico Experiments and Back
Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents.
Multiple Testing Procedures and Applications to Genomics
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. The methods are applied to a range of testing problems in biomedical and genomic research, including the identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments.
Multiple Sclerosis: Autoimmunity and Management
Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20–25 years in more than 30% of patients. The hallmark of MS is symptomatic episodes that occur months or years apart and affect different anatomic locations. Also, see the Autoimmune Disorders: Making Sense of Nonspecific Symptoms slideshow to help identify several diseases that can cause a variety of nonspecific symptoms. MS is diagnosed on the basis of clinical findings and supporting evidence from ancillary tests. Treatment consists of immunomodulatory therapy for the underlying immune disorder and management of symptoms, as well as nonpharmacologic treatments, such as physical and occupational therapy. Disease-modifying therapies have shown beneficial effects in patients with relapsing MS, including reduced frequency and severity of clinical attacks. These agents appear to slow the progression of disability and the reduce accumulation of lesions within the brain and spinal cord.
Multiple Abstraction Hierachies for Mobile Robot Operation in Large Environments
This book focuses on the efficient performance of mobile robots through the use of multi-hierarchical symbolic representations of the environment. A mobile robot intended to perform deliberative actions must possess some symbolic representation of its workspace, but such representations of real environments usually become so large that should be conveniently arranged in order to facilitate and, in some cases, make possible their use. This book addresses all these issues considering symbolic multi-hierarchical structures. Such structures, based on the concept of abstraction, allow a robot to speed up its operation in large environments. Practical solutions tested on real robots (for instance, a robotic wheelchair for elder people) are provided.
Multimodal Video Characterization and Summarization
Multimodal Video Characterization and Summarization is a valuable research tool for both professionals and academicians working in the video field. This book describes the methodology for using multimodal audio, image, and text technology to characterize video content. This new and groundbreaking science has led to many advances in video understanding, such as the development of a video summary. Applications and methodology for creating video summaries are described, as well as user-studies for evaluation and testing.
Multimedia Introduction to Programming Using Java
Although vital to modern software development, Java and object-oriented programming can pose significant challenges to newcomers. This text, unique in both scope and approach and accompanied by interactive content that you may find on extras.springer.com, addresses that learning curve by providing a careful, classroom-tested presentation of Java -- from the fundamentals of variables, types, and expressions to procedural concepts like loops and sophisticated object-oriented ideas. Additional key features of this work Introduces objects and classes early in the exposition, rendering object-oriented programming intuitive and natural. Develops programs, rather than simply showcasing them. Supports all concepts through complementary lectures on the zip-file featured on extras.springer.com. Contains numerous self-help exercises that encourage readers to practice programming. With its comprehensive appendices and bibliography, systematic approach, and helpful interactive programs on extras.springer.com, this exciting work provides the key tools they needed for successful object-oriented programming. It is ideal for use at the undergraduate and graduate beginning level, whether in the classroom or for distance learning; furthermore, the text will also be a valuable self-study resource or reference volume in any programmer’s library.
Multimedia Database Retrieval : A Human-Centered Approach
Multimedia Database Retrieval: A Human-Centered Approach presents the latest development in user-centered methods and the state-of-the-art in visual media retrieval. It includes discussion on perceptually inspired non-linear paradigm in user-controlled interactive retrieval (UCIR) systems. It also features a coherent approach which focuses on specific topics within content/concept-based retrievals via audio-visual information modeling of multimedia. Highlights include: * Exploring an adaptive machine that can learn from its environment * Optimizing the learning system by incorporating self-organizing adaptation into the retrieval process * Demonstrating state-of-the-art applications within small, medium, and large databases
Multibody Dynamics : Computational Methods and Applications
This book contains the revised and extended versions of selected conference communications, representing the state-of-the-art in the advances on computational multibody models, from the most abstract mathematical developments to practical engineering applications. This book will be highly valuable for experienced researchers that want to keep updated on the details of the latest driving ideas in this field. It will also be of interest to researchers approaching the field for the first time, since it provides a useful overview of the most active areas and the efforts devoted by many prominent research groups worldwide.
Multi-Agent Systems and Applications ; 9th ECCAI Advanced Course ACAI 2001 and Agent Link's 3rd European Agent Systems Summer School, EASSS 2001, Prague, Czech Republic, July 2-13, 2001. Selected Tutorial Papers
The Advanced Course on Artificial Intelligence ACAI 2001 with the subtitle M ulti- Agent Systems and Their Applications , held in Prague, Czech Republic, was a joint event of ECCAI (the European Coordinating Committee for Artificial Intelligence) and AgentLink, the European Network of Excellence for Agent-Based Computing. Whereas ECCAI organizes two-week ACAI courses on different topics every second year, AgentLink s European Agent Systems Summer School (EASSS) has been an annual event since 1999. This year, both of these important events were merged together, giving weight to the fact that multi-agent systems currently represent one of the hottest topics in AI research. The name, ACAI 2001 Summer School, is intended to emphasize that this event continues the tradition of regular ECCAI activities (ACAI), as well as the EASSS summer schools of AgentLink.
Multiagent System Technologies ; Vol. 3550 : 3rd German Conference, MATES 2005, Koblenz, Germany, September 11-13, 2005, Proceedings
After two successful MATES conferences in Erfurt 2003 and 2004, the 3rd G- man conference on Multi-agent System Technologies (MATES 2005) took place in Koblenz, Germany, in September 2005, and was co-located with the 28th German Conference on Arti?cial Intelligence (KI 2005). Building onotheragent-related events in Germany in the past, and organized by the GI German Special Interest Group on Distributed Arti?cial Intelligence, the MATES conference series aims at promoting the theory and applications of agents and multiagent systems. In corporating the 9th International Workshopon Cooperative Information Agents (CIA 2005), the topics of interest for MATES 2005 also covered the ?elds of intelligent information agents and systems for the Internet and the (Semantic) Web. As in recent years, MATES 2005 provided a distinguished, lively and int- disciplinary forum for researchers, users, and developers of agent technology, to present and discuss the latest advances of research and development in the area of autonomous agents and multiagent systems. Accordingly, the topics of MATES 2005 covered the whole range from the theory to applications of age- and multiagent technology. The technical program included a total of 24 sci- ti?c talks, and demonstrations of selected running agent systems, and both the MATES 2005 Best Paper and the CIA 2005 System Innovation awards.
Multiagent System Technologies ; 6th German Conference, MATES 2008, Kaiserslautern, Germany, September 23-26, 2008. Proceedings
This book constitutes the refereed proceedings of the 6th German Conference on Multiagent Systems Technologies, MATES 2008, held in Kaiserslautern, Germany, in September 2008 - co-located with the 31st German Conference on Artificial Intelligence, KI 2008.The 16 revised full papers presented together with 2 invited talks were carefully reviewed and selected from 35 submissions. The papers present and discuss the latest advances of research and development in the area of autonomous agents and multiagent systems ranging from theoretical and methodological issues to applications in various fields.
Mucosal Immunology and Virology
Mucosal Immunology and Virology is designed to provide the clinician with a thorough and yet approachable textbook describing the relationships between immunology, virology and the disease process. It includes a vast wealth of information and illustrations to enable the reader to become familiar with the clinical presentation of these diseases, the tests needed to establish the diagnosis, and the treatment of the disease including specific antiviral agents. Suitable for residents and clinicians in immunology, infectious diseases, internal medicine and dermatology the book reviews the systematic manifestations of mucosal viral infections, including those involving the mouth, gastrointestinal tract, respiratory system, anogenital mucosa and ocular infections
Mucins : Methods and protocols
Explores the latest advancements in mucin research. The chapters in this book are organized into 8 parts and cover a wide range of topics such as mucin extraction, isolation, physicochemical property analysis, and experimental methods. The chapters also discuss the origins of mucins in jellyfish, feces, saliva and salivary glands, bronchi, stomach, and cervical tract; organic synthesis of peptides glycosylated at specific sites; analysis of mucin gene expression and methylation-specific electrophoresis of genes; imaging of mucin networks by AFM; and experimental methods using supported molecular matrix electrophoresis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
MRI of the Liver : Imaging Techniques, Contrast Enhancement, Differential Diagnosis
Due to the latest developments in magnetic resonance imaging for the evaluation of liver pathology, a second, completely revised and enlarged edition of this book was felt necessary – despite only three years having elapsed since the first edition. New chapters have been added covering important and highly relevant topics, among which imaging of pseudolesions, imaging of neoplastic diseases in pediatric subjects, imaging of bile ducts, MR angiography and imaging pre and post liver transplantation.
