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Basic principles of drug discovery and development ; 2nd ed.
Presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields.
Balloon Kyphoplasty
This book focuses on balloon kyphoplasty and alter- tive minimally invasive treatments for stabilization of osteoporotic vertebral fractures. The optimal treatment of a patient with osteoporotic vertebral fractures requires an interdisciplinary - proach, and therefore our book draws on the expertise of orthopedic surgeons, traumatologists and neu- surgeons, and also includes a chapter on medical treatment.
Autoformation et aide au diagnostic en hématologie avec le logiciel ADH = Self-study and diagnostic aid in hematology with ADH software
The software includes a rich iconography on blood and marrow cells which will complement the knowledge in cytology of hematologists. Certain cytological abnormalities encountered in certain pathologies are also presented.
Atrial Fibrillation : From bench to bedside
This book is a single source that provides a multi-perspective look at and approach to Atrial Fibrillation. Because Atrial Fibrillation is so prevalent and affects all areas of medicine, the information in this book will be useful to cardiologists, cardiac surgeons, researchers, and all those in the medical field.
Asymmetric Cell Division
Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
Applied Peritoneal Dialysis : Improving Patient Outcomes
This book offers a comprehensive guide to peritoneal dialysis (PD). Home dialysis, and more specifically PD, is growing in popularity in the US. By conservative estimates, experts suggest that 45 percent of dialysis patients in the US can be on home dialysis. However, the current penetration rate is only 10 percent. This is changing with an expected major increase in the next 5 years. One of the reasons for the low uptake is that many nephrologists lack comfort and confidence in using PD as a dialysis modality.
Aortic dissection and related syndromes
Aortic dissection affects approximately two in ten thousand individuals and can be fatal. This state-of-the-art publication is a result of the combined efforts of participants from the International Registry of Aortic Dissection (IRAD). The book has been divided into sections. Each chapter provides a succinct overview of the current clinical literature and incorporates illustrations for further explanation.
Anti-viral metabolites from medicinal plants
Covers general concepts of anti-viral metabolites, classifications, ethnopharmacology, chemistry, clinical and preclinical studies focusing on different medicinal plants against various types of viral infections. Various plants have been used in medicine since ancient times and are known for their strong therapeutic effects. The book will describe potential antiviral properties of medicinal plants against a diverse group of viruses, and provide an insight to the potential plants possess for broad-spectrum antiviral effects against emerging viral infections.The book aims to target a broad audience including virologists, molecular biologist, microbiologist and scientists working with natural products as well as researchers, students, healthcare experts involved in pharmaceutical and medical field.
Anthropologies of Global Maternal and Reproductive Health : From Policy Spaces to Sites of Practice
This open access edited book brings together new research on the mechanisms by which maternal and reproductive health policies are formed and implemented in diverse locales around the world, from global policy spaces to sites of practice. The authors – both internationally respected anthropologists and new voices – demonstrate the value of ethnography and the utility of reproduction as a lens through which to generate rich insights into professionals’ and lay people’s intimate encounters with policy.
Anatomical Imaging : Towards a New Morphology
This book presents selected works of contemporary evolutionary morphologists and includes such topics as broad scale reconstructions of the brain and ear of dinosaurs, inference of locomotor habits from cancellous bone architecture in fossil primates, and a comparison of the independently evolved manipulating apparatuses in the lesser and giant pandas. Insight is provided into the application of modern noninvasive technologies, including digital imaging techniques and virtual 3D reconstruction, to the investigation of complex anatomical features and coherences. In combination with traditional methods, this allows for the formulation of improved hypotheses on coordinated function and evolution. The creation of virtual translucent specimens makes it possible to realize the age-old dream of the classical anatomists: looking through the skin into the inner organization of an organism. On full display here is the dramatic and promising impact that modern imaging techniques have on scientific progress in evolutionary morphology.
Analysing Ecological Data
This book provides a practical introduction to analysing ecological data using real data sets collected as part of postgraduate ecological studies or research projects. The first part of the book gives a largely non-mathematical introduction to data exploration, univariate methods (including GAM and mixed modelling techniques), multivariate analysis, time series analysis (e.g. common trends) and spatial statistics. The second part provides 17 case studies, mainly written together with biologists who attended courses given by the first authors. The case studies include topics ranging from terrestrial ecology to marine biology.
Allergy in Practice
This book reflects the rich personal experience of a German allergist with international training and reputation, who is active in immunology and allergy research and practice for almost 30 years. In this book, not only IgE-mediated allergic reactions are covered but all other kinds of allergies such as atopic eczema, contact dermatitis, drug eruptions, anaphylaxis and food allergies are equally represented as well as psychosomatic aspects and problems of environmental intolerances.
Algal Chemical Ecology
This is the first ever book devoted entirely to the chemical ecology of algae. Algae from both marine and freshwater habitats are covered, as are macroalgae (seaweeds) and microalgae (including phytoplankton). While its main emphasis is on the ecological rather than chemical aspects of the field, the book also includes a unique introductory chapter intended as a primer on algal natural products chemistry for ecologists. It elucidates the roles of chemical defenses in various regions and habitats, of DMSP, oxidative burst responses, and herbivore offense. Topics such as algal sensory chemical ecology and defenses against ultraviolet radiation are also treated, and an introduction to the chemical ecology of phytoplankton is provided.
Aging and the Heart : A Post-Genomic View
In this book, the genetic and molecular basis of cardiovascular aging will be discussed. In addition, a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic and future therapeutic modalities will be undertaken.
Advances in Algal Biology : A Commemoration of the Work of Rex Lowe
Advances in Algal Biology: A Commemoration of the Work of Rex Lowe was written by students and colleagues of Rex Lowe to acknowledge his esteemed career that included exceptional contributions to research and teaching. Papers in the book cover a variety of topics in algal ecology, focusing on benthic algal ecology in freshwater ecosystems. The studies provide an unusual combination of small-scale experiments and large-scale regional surveys that bridge both basic and applied ecology. Ecologists, limnologists, phycologists, and environmental scientists will find valuable contributions to the development and application of algal research.
Advanced Imaging of the Abdomen
Bridges the clinician-radiologist interface on unusual clinical presentations and imaging findings. It explores imaging approaches to solve a particular problem.
Active Processes and Otoacoustic Emissions in Hearing
Sounds that are actually produced by healthy ears allow researchers and clinicians to study hearing and cochlear function noninvasively in both animals and humans. Active Processes and Otoacoustic Emissions in Hearing presents the first serious review of the biological basis of these otoacoustic emissions. Active processes, such as those in hair cells that produce emissions, represent a burgeoning and important area of sensory research. By providing a basis for understanding how and why otoacoustic emissions testing works through a basic understanding of general hearing processes, this volume will also interest clinicians, particularly otolaryngologists and audiologists.
Acetylsalicylic Acid
Contains the latest results of clinical and pharmacological research on Acetylsalicylic acid, addressing the multiple pharmacological properties of this famous drug with a balanced view on their translation into clinical practice, including prevention and treatment of cardiovascular diseases, thromboinflammation and colorectal cancer. Understandable for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
A Changing World : Challenges for Landscape Research
Written primarily for researchers and advanced students in environmental and social sciences, this latest book in Springer’s Landscape Series looks at some of the emerging fields and new challenges in landscape research. These include: the role of value systems in perceiving, appreciating, and managing landscapes the ‘space’ and ‘place’ concept in landscape research GIS and remote sensing techniques for gathering and processing spatially and temporally explicit land cover, vegetation, and land use data methods of landscape history landscape genetics and genetic methods to test landscape connectivity and dispersal of plant and animal species
Law, surveillance and the humanities
Explores key issues such as the use and legitimacy of surveillance to address a global health crisis, the role of surveillance in the experience of indigenous peoples in post-colonial societies, how surveillance interacts with gender, race, ethnicity, and social class, and the interaction between technology, surveillance, and changing attitudes to expression. how philosophy and sociology can help to correct biases and law and politics can offer new approaches to the legitimacy, use and implications of surveillance.
