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Gene delivery systems development and applications
Covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases.
Game Theory : Decisions, Interaction and Evolution
This introduction to game theory is written from a mathematical perspective. Its primary purpose is to be a first course for undergraduate students of mathematics, but it also contains material which will be of interest to advanced students or researchers in biology and economics.An understanding of basic calculus and probability is assumed but no prior knowledge of game theory is required. Detailed solutions are provided for the numerous exercises.
Game Theory : A Multi-Leveled Approach
This book presents the basics of game theory both on an undergraduate level and on a more advanced mathematical level. It covers most topics of interest in game theory, including cooperative game theory. Part I presents introductions to all these topics on a basic yet formally precise level. It includes chapters on repeated games, social choice theory, and selected topics such as bargaining theory, exchange economies, and matching. Part II goes deeper into noncooperative theory and treats the theory of zerosum games, refinements of Nash equilibrium in strategic as well as extensive form games, and evolutionary games. Part III covers basic concepts in the theory of transferable utility games, such as core and balancedness, Shapley value and variations, and nucleolus. Some mathematical tools on duality and convexity are collected in Part IV. Every chapter in the book concludes with a problem section. Hints, answers and solutions are included.
Galling Arthropods and Their Associates ; Ecology and Evolution
The book addresses recent developments in the ecology, evolution, systematics, physiology, and biodiversity of gall-inducing arthropods, with individual contri butions ranging in scope from detailed descriptions to profoundly synthetic stud ies. One underlying theme of the book is the various impacts of gall induction that indirectly affect insect communities on the host plant. The other important contri bution is the highly intricate and dynamic interactions between galling arthropods and their uniquely specialized host plants. Included also are chapters that discuss biodiversity and distribution patterns of gall-inducing arthropods, and biological control of invasive gall-inducing arthropods and of invasive trees. We believe that this book makes an important contribution to the knowledge of galling arthropods and their associates and to the development of robust, general principles of the ecology and evolution of these organisms.
Galileo Galilei - When the World Stood Still
"I, Galileo, son of the late Vincenzio Galilei, Florentine, aged seventy years ...kneeling before you Most Eminent and Reverend Lord Cardinals ...I abjure, curse, detest the aforesaid errors and heresies."The mathematician and physicist Galileo Galilei is one of the most famous scientists of all times. The story of his life and times, of his epoch-making experiments and discoveries, of his stubbornness and pride, of his patrons in the house of Medici, of his enemies and friends in their struggle for truth - all is brought vividly to life in this book. Atle Næss has written a gripping account of one of the great figures in European history.
Galaxy Formation and Evolution
An Astronomical Life – Observing the Depths of the Universe” Though science as a subject can be di?cult, what has been more important for me is that its practice can also be rewarding fun! This book is crafted to expose the reader to the excitement of modern observational cosmology through the study of galaxy evolution over space and cosmic time. Recent extragalactic research has led to many rapid advances in the ?eld. Even a suitable skeptic of certain pronouncements about the age and structure of the Universe should be pleased with the large steps that have been taken in furthering our understanding of the Universe since the early 1990’s. My personal involvement in galaxy research goes back to the 1960’s. At that point, galaxies were easily recognized and partially understood as organized c- lections of stars and gas. What their masses were presented a problem, which I supposed would just fade away. But fade it didn’t. Distant active nuclei and quasars were discovered in the mid-1960’s. A c- mon view of QSOs was that they have large redshifts, but what use are they for cosmology or normal galaxy astrophysics? I shared that conclusion. My expec- tions fell below their potential utility. In short, the Universe of our expectations rarely matches the Universe as it is discovered.
Galaxy Formation
This second edition of Galaxy Formation is an up-to-date text on astrophysical cosmology, expounding the structure of the classical cosmological models from a contemporary viewpoint. This forms the background to a detailed study of the origin of structure and galaxies in the Universe. The derivations of many of the most important results are derived by simple physical arguments which illuminate the results of more advanced treatments. A very wide range of observational data is brought to bear upon these problems, including the most recent results from WMAP, the Hubble Space Telescope, galaxy surveys like the Sloan Digital Sky Survey and the 2dF Galaxy Redshift Survey, studies of Type 1a supernovae, and many other observations.
Galactose Regulon of Yeast : From Genetics to Systems Biology
The galactose regulon of yeast is one of the best studied regulons. It is an ideal paradigm for demonstrating fundamental and evolving concepts in biology and is used in this book as a model system to explain various facets of conventional and modern biology. The book starts with a brief historical overview on yeast research, i.e. early observations in enzyme adaptation, classical genetics, formulating hypotheses based on genetic inference. This is followed by molecular genetics of the galactose regulon, isolation of genes and testing of the hypotheses. The power of mutational analysis in deciphering molecular mechanisms is conveyed. Further, contemporary topics such as genomics, evolution, single cell analysis of transcriptional switching, binary and graded responses, biological consequences of feed back regulation in genetic circuits, and stochasticity are addressed.
Fuzzy systems and knowledge discovery ; Vol. 4223 ; Third International Conference, FSKD 2006, Xi'an, China, September 24-28, 2006, Proceedings
ICNC-FSKD 2006 featured the most up-to-date research results in com- tational algorithms inspired from nature, including biological, ecological, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide rangeof techniques and methods arebeing studied for dealing with large, complex, and dynamic problems.
Fuzzy systems and knowledge discovery ; Vol. 3614 ; 2nd International Conference, FSKD 2005, Changsha, China, August 27-29, 2005, Proceedings, Part II
This book and its sister volume, LNAI 3613 and 3614, constitute the proce- ings of the Second International Conference on Fuzzy Systems and Knowledge Discovery (FSKD 2005), jointly held with the First International Conference on Natural Computation (ICNC 2005, LNCS 3610, 3611, and 3612) from - gust 27–29, 2005 in Changsha, Hunan, China. FSKD 2005 successfully attracted 1249 submissions from 32 countries/regions (the joint ICNC-FSKD 2005 received 3136 submissions). After rigorous reviews, 333 high-quality papers, i. e. , 206 long papers and 127 short papers, were included in the FSKD 2005 proceedings, r- resenting an acceptance rate of 26. 7%. The ICNC-FSKD 2005 conference featured the most up-to-date research - sults in computational algorithms inspired from nature, including biological, e- logical, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide range of techniques and methods are being studied for dealing with large, complex, and dynamic problems. The joint conferences also promoted cross-fertilization over these exciting and yet closely-related areas, which had a signi?cant impact on the advancement of these important technologies. Speci?c areas included computation with words, fuzzy computation, granular com- tation, neural computation, quantum computation, evolutionary computation, DNA computation, chemical computation, information processing in cells and tissues, molecular computation, arti?cial life, swarm intelligence, ants colony, arti?cial immune systems, etc. , with innovative applications to knowledge d- covery, ?nance, operations research, and more.
Fuzzy systems and knowledge discovery ; Vol. 3613 ; 2nd International Conference, FSKD 2005, Changsha, China, August 27-29, 2005, Proceedings, Part I
This book and its sister volume, LNAI 3613 and 3614, constitute the proce- ings of the Second International Conference on Fuzzy Systems and Knowledge Discovery (FSKD 2005), jointly held with the First International Conference on Natural Computation (ICNC 2005, LNCS 3610, 3611, and 3612) from - gust 27–29, 2005 in Changsha, Hunan, China. FSKD 2005 successfully attracted 1249 submissions from 32 countries/regions (the joint ICNC-FSKD 2005 received 3136 submissions). After rigorous reviews, 333 high-quality papers, i. e. , 206 long papers and 127 short papers, were included in the FSKD 2005 proceedings, r- resenting an acceptance rate of 26. 7%. The ICNC-FSKD 2005 conference featured the most up-to-date research - sults in computational algorithms inspired from nature, including biological, e- logical, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide range of techniques and methods are being studied for dealing with large, complex, and dynamic problems. The joint conferences also promoted cross-fertilization over these exciting and yet closely-related areas, which had a signi?cant impact on the advancement of these important technologies. Speci?c areas included computation with words, fuzzy computation, granular com- tation, neural computation, quantum computation, evolutionary computation, DNA computation, chemical computation, information processing in cells and tissues, molecular computation, arti?cial life, swarm intelligence, ants colony, arti?cial immune systems, etc. , with innovative applications to knowledge d- covery, ?nance, operations research, and more.
Fuzzy Logic and Applications ; Vol. 3849 ; 6th International Workshop, WILF 2005, Crema, Italy, September 15-17, 2005, Revised Selected Papers
This volume contains the proceedings of the 6th International Workshop on Soft Computing and Applications (WILF 2005), which took place in Crema, Italy, on September 15–17, 2005, continuing an established tradition of biannual meetings among researchers and developers from both academia and industry to report on the latest scienti?c and theoretical advances, to discuss and debate major issues, and to demonstrate state-of-the-art systems. This edition of the workshop included two special sessions, sort of subwo- shops, focusing on the application of soft computing techniques (or compu- tional intelligence) to image processing (SCIP) and bioinformatics (CIBB).
Fuzzy Applications in Industrial Engineering
After an introductory chapter explaining the recent status of fuzzy sets in IE, this volume involves application chapters on the major seven areas of IE to which fuzzy set theory can contribute. These major application areas are Control and Reliability, Engineering Economics and Investment Analysis, Group and Multi-criteria Decision-making, Human Factors Engineering and Ergonomics, Manufacturing Systems and Technology Management, Optimization Techniques, and Statistical Decision-making. Under these major areas, every chapter includes didactic numerical applications.
Fungal Genomics
Presents an overview on mutualistic and pathogenic interactions between fungi and plants. This book offers reviews on fungal lifestyles, mechanisms of their interactions with their host plants, signal perception and transduction, and plant defense responses directed against attack by fungal pathogens. It is suitable for students in microbiology.
Funds, Flows and Time : An Alternative Approach to the Microeconomic Analysis of Productive Activities
The subject of this book is production, which is an important and extensive field in economic science. In fact, production, distribution and consump tion were long considered the three federated kingdoms which together formed the great empire of the economy. According to other slightly dif ferent traditions, production also held pride of place, specifically as a basic link in the long chain of social reproduction. Today, whatever the theoreti cal approach, production is a fundamental requirement for human survival. This was not, however, always the case. For much of the history of man kind hominids were hunter, scavenger and gatherers, with very little con trol over their environment, and extremely little in the way of artefacts with which to work. However, since the Neolithic revolution, productive processes have constituted an essential mechanism, providing human soci ety with goods and services to satisfy its needs and cravings.
Fundamentals of the New Artificial Intelligence: Neural, Evolutionary, Fuzzy and More
The significantly updated second edition of Fundamentals of the New Artificial Intelligence thoroughly covers the most essential and widely employed material pertaining to neural networks, genetic algorithms, fuzzy systems, rough sets, and chaos. In particular, this unique textbook explores the importance of this content for real-world applications.
Fundamentals of Space Biology : Research on Cells, Animals, and Plants in Space
This book is intended as an overview at the undergraduate or early university level and describes the effects of spaceflight at cellular and organism levels. Past, current, and future research on the effects of gravity--or its absence--and ionizing radiation on the evolution, development, and function of living organisms is presented in layman's terms by researchers who have been active in this field. The purpose is to enlighten science and non-science readers to the benefits of space biology research for conducting basic and applied research to support human exploration of space. Also covered are the advantages of approaching the space environment as a laboratory for scientific, technological, and commercial research.
Fundamentals of roman private law
Roman law forms a vital part of the intellectual background of many legal systems currently in force in Continental Europe, Latin America, East Asia and other parts of the world. Knowledge of Roman law, therefore, constitutes an essential component of a sound legal education as well as the education of the student of history. This book begins with a historical introduction, which traces the evolution of Roman law from the earliest period of Roman history up to and including Justinian's codification in the sixth century AD.
Fundamentals of clinical research : Bridging medicine, statistics and operations
The scope of clinical research is to evaluate the effect of a treatment on the evolution of a disease in the human species.The treatment can be pharmacological, surgical, psychological/behavioral or organizational/logistic. The disease, intended as an impairment of a state of well-being or a condition capable of provoking such impairment over time, can be universally accepted as such (e.g. a cancer or a bone fracture) or perceived as such only by limited groups of individuals in a given cultural context (e.g. hair loss or weight gain). The course of the disease that ones wishes to change can be the one with no intervention or, more frequently, the one observed with the available treatment. The evaluation of the effect of a treatment on the course of a disease is a lengthy process, which progresses in increasingly complex stages.
Fundamental approaches to software engineering ; 25th International Conference, FASE 2022, Held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2022, Munich, Germany, April 2–7, 2022, Proceedings
The papers deal with the foundations on which software engineering is built, including topics like software engineering as an engineering discipline, requirements engineering, software architectures, software quality, model-driven development, software processes, software evolution, AI-based software engineering, and the specification, design, and implementation of particular classes of systems, such as (self-)adaptive, collaborative, AI, embedded, distributed, mobile, pervasive, cyber-physical, or service-oriented applications.
