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Molecular Markers of Brain Tumor Cells : Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy
Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.
Molecular Gas Dynamics : Theory, Techniques, and Applications
This self-contained work is an up-to-date treatment of the basic theory of molecular gas dynamics and its various applications. Recent progress in the field has greatly enhanced the original theory and stimulated interesting and critical gas dynamic phenomena and problems. This book, unique in the literature, presents working knowledge, theory, techniques, and typical phenomena in rarefied gases for theoretical development and applications.
Molecular Diagnostic PCR Handbook
PREFACE The Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture is involved in agricultural research and development and assists Member States of FAO and IAEA in improving strategies to ensure food security through the use of nuclear techniques and related biotechnologies, where such techniques have a valuable and often unique role. In particular, molecular diagnostic methods have rapidly evolved in the past twenty years, since the advent of the Polymerase Chain Reaction (PCR). They are used in a wide range of agricultural areas such as, improving soil and water management; producing better crop varieties; diagnosing plant and animal diseases; controlling insect pests and improving food quality and safety. The uses of nucleic acid-directed methods have increased significantly in the past five years and have made important contributions to disease control country programmes for improving national and international trade. These developments include the more routine use of PCR as a diagnostic tool in veterinary diagnostic laboratories. However, there are many problems associated with the transfer and particularly, the application of this technology. These include lack of consideration of: the establishment of quality-assured procedures, the required set-up of the laboratory and the proper training of staff. This can lead to a situation where results are not assured. This book gives a comprehensive account of the practical aspects of PCR and strong consideration is given to ensure its optimal use in a laboratory environment. This includes the setting-up of a PCR laboratory; Good Laboratory Practice and standardised of PCR protocols.
Molecular Biology of the Parathyroid
Caintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex pression to its intracellular processing and the sequences in the gene control ling its transcription as well as those regulating mRNA processing, stability and translation are described.
Modern Trends in Pseudo-Differential Operators
The ISAAC Group in Pseudo-diferential Operators (IGPDO) was formed at the Fourth ISAAC Congress held at York University in Toronto in 2003 and the Frst volume entitled Advances in Pseudo-di?erential Operators and devoted to papers focussing on pseudo-di?erential operators and its diverse applications was then initiated and published in Professor Israel Gohberg’s series Operator Theory: - vances and Applications in 2004.The vision is to seek new directionsfor the broadsubjectonpseudo-diferentialoperatorsand the strategy is to devote the Catania Volume not only to papers based on lectures given at the special session on pseudo-diferential operators, but also invited - pers that bear on the themes of IGPDO.
Modern Operative Dentistry : Principles for Clinical Practice
Provides the theoretical knowledge required by students when learning how to diagnose oral diseases, plan treatment, and perform various types of dental restoration. It is also useful for clinicians wishing to update their treatment skills and broaden their understanding operative dentistry. Adopting an evidence-based approach, and in accordance with the philosophy of minimally invasive dentistry, it explains in detail the use of both classic and new restorative materials in various clinical situations. It also discusses the principles of smile analysis, as well the technique for esthetic composite restorations on posterior and anterior teeth, including direct and indirect veneers.
Modern front-end architecture : Optimize your front-end development with components, storybook, and mise en place philosophy
Learn how to build front-end applications that can help you ship applications faster with fewer defects. Many software projects fail because they are not planned well, or lack organization. Applying strategies from other industries can help you create better software. Explores the “mise en place” technique from cooking and reveals how you can apply it to the art of creating software. Describes to how to structure your code base for reuse, and how to communicate the code’s intent to other developers. You’ll develop your components in isolation and test these building blocks for quality at a granular level. Then compose these components as building blocks in increasingly complicated features. Finally, you’ll apply some strategies not directly related to code to ensure maximum quality and efficiency. You will : Structure an application as a series of components / Build a component library that others in an organization can leverage / Ensure quality and accessibility at a component level rather than a page or app level / Test code in a way that gives the maximum amount of confidence while providing an excellent developer experience / Automate repeatable tasks
Modeling and computations in electromagnetics ; A volume dedicated to Jean-Claude Nédélec
Modeling and computations in electromagnetics is a quite novel and growing discipline, expanding as a result of the steadily increasing demand for designing electrical devices, modeling electromagnetic materials, and simulating electromagnetic fields in nanoscale structures. The aim of this volume is to bring together prominent worldwide experts to review state-of-the-art developments and future trends of modeling and computations in electromagnetics. This volume is devoted to merging the expertise of scientists working in this dynamic discipline, and to raising interest for challenging issues. The most significant advances in computational techniques have been made only in the last few years, and several challenging technological applications are presented in this volume.
Model Driven Architecture ; European MDA Workshops : Foundations and Applications, MDAFA 2003 and MDAFA 2004, Twente, The Netherlands, June 26-27, 2003, and Linköping, Sweden, June 10-11, 2004, Revised Selected Papers
Model-Driven Architecture (MDA) is an initiative proposedby the Object M- agement Group (OMG) for platform-generic software development. MDA s- arates the specification of system functionality from the implementation on a specific platform. It is aimed at making software assets more resilient to changes caused by emerging technologies. While stressing the importance of modeling, the MDA initiative covers a wide spectrum of research areas. Further efforts are required to bring them into a coherent approach based on open standards and supported by matured tools and techniques. This volume contains the selected papers of two workshops on “Model-Driven Architecture – Foundations and Applications” (MDAFA): MDAFA 2003 held at the University of Twente, Twente, The Netherlands, June 26–27, 2003, and MDAFA 2004 held at Linko ¨ping University, Link¨ oping, Sweden, June 10–11, 2004. The goal of the workshops was to understand the foundations of MDA, to share experience in applying MDA techniques and tools, and to outline future research directions. The workshops organizers encouraged authors of accepted papers to re-submit their papers to a post-workshop reviewing process; 15 of these papers were accepted to appear in this volume on MDA.
Model checking software ; 14th International SPIN Workshop, Berlin, Germany, July 1-3, 2007, Proceedings
This book presents the proceedings of the 14th International SPIN workshop on Model Checking Software, held in Berlin, Germany. The papers are organized into topical sections covering directed model checking, partial order reduction, program analysis, exploration advances, modeling and case studies, and tool demonstrations.
Mobile Service Innovation and Business Models
Modern economies depend on innovation in services for their future growth. Service innovation increasingly depends on information technology and digitization of information processes. Designing new services is a complex matter, since collaboration with other companies and organizations is necessary. Service innovation is directly related to business models that support these services, i.e. services can only be successful in the long run with a viable business model that creates value for its customers and providers. This book presents a theoretically grounded yet practical approach to designing viable business models for electronic services, including mobile ones, i.e. the STOF model and – based on it – the STOF method. The STOF model provides a ‘holistic’ view on business models with four interrelated perspectives, i.e., Service, Technology, Organization and Finance. It elaborates on critical design issues that ultimately shape the business model and drive its viability.
Mobile and Wireless Network Security and Privacy
Mobile and Wireless Network Security and Privacy analyzes important security and privacy problems in the realms of wireless networks and mobile computing. The material includes a report to the National Science Foundation of the United States which will be used by program managers for the foundation in setting priorities for research directions in this area. In the following chapters field experts expand upon the report and provide further information about important research directions in the fields of wireless networks and mobile computing. The chapters are written by the leading international researchers and professionals in thes fields. Each chapter represents state-of-the-art research and includes several influential contributions. A multitude of valuable discussions on relevant concepts, such as the various approaches that define emerging security and privacy in mobile and wireless environment, are featured.
Mixed-criticality industrial wireless networks
Introduces criticality to label important data,which is then allocated more transmission resources, ensuring that important data’sQoS requirements can be met to the extent possible.To help readers understand how to apply mixed criticality to industrial wirelessnetworks, the content is divided into four parts. First, we introduce how to integratethe model of mixed-criticality data into industrial wireless networks (Chap. 1).Second, we explain how to analyze the schedulability of mixed-criticality data underexisting scheduling algorithms (Chaps. 2 and 3). Third, we present a range of novelscheduling algorithms for mixed-criticality data (Chaps. 4, 5, and 6). Finally, weconclude this book and discuss future research directions (Chap. 7).
Mission AI: the new system technology
Offers a strategic perspective on AI and the process of embedding it in society. After decades of research, Artificial Intelligence (AI) is now entering society at large. Due to its general purpose character, AI will change society in multiple, fundamental and unpredictable ways. Therefore, the Netherlands Scientific Council for Government Policy (WRR) characterizes AI as a system technology: a rare type of technologies that have a systemic impact on society. Earlier system technologies include electricity, the combustion engine and the computer. The history of these technologies provides us with useful insights about what it takes to direct the introduction of AI in society.
Mirror Geometry of Lie Algebras, Lie Groups and Homogeneous Spaces
As K. Nomizu has justly noted [K. Nomizu, 56], Differential Geometry ever will be initiating newer and newer aspects of the theory of Lie groups. This monograph is devoted to just some such aspects of Lie groups and Lie algebras. New differential geometric problems came into being in connection with so called subsymmetric spaces, subsymmetries, and mirrors introduced in our works dating back to 1957 [L.V. Sabinin, 58a,59a,59b]. In addition, the exploration of mirrors and systems of mirrors is of interest in the case of symmetric spaces. Geometrically, the most rich in content there appeared to be the homogeneous Riemannian spaces with systems of mirrors generated by commuting subsymmetries, in particular, so called tri-symmetric spaces introduced in [L.V. Sabinin, 61b]. As to the concrete geometric problem which needs be solved and which is solved in this monograph, we indicate, for example, the problem of the classification of all tri-symmetric spaces with simple compact groups of motions. Passing from groups and subgroups connected with mirrors and subsymmetries to the corresponding Lie algebras and subalgebras leads to an important new concept of the involutive sum of Lie algebras [L.V. Sabinin, 65]. This concept is directly concerned with unitary symmetry of elementary par- cles (see [L.V. Sabinin, 95,85] and Appendix 1). The first examples of involutive (even iso-involutive) sums appeared in the - ploration of homogeneous Riemannian spaces with and axial symmetry. The consideration of spaces with mirrors [L.V. Sabinin, 59b] again led to iso-involutive sums.
Mini-Micro Fuel Cells : Fundamentals and Applications
This volume contains an archival record of the NATO Advanced Institute on Mini – Micro Fuel Cells – Fundamental and Applications held in Çesme – Izmir, Turkey, July 22–August 3, 2007. The ASIs are intended to be a high-level teaching activity in scientific and technical areas of current concern. In this volume, the reader may find interesting chapters on Mini- Micro Fuel Cells with fundamentals and applications. In recent years, fu- cell development, modeling and performance analysis has received much attention due to their potential for distributed power which is a critical issue for energy security and the environmental protection.
Migration and Discrimination : IMISCOE Short Reader
This book provides a state of the art overview of the discrimination research field, with particular focus on discrimination against immigrants and their descendants. It covers the ways in which discrimination is defined and conceptualized, how it is measured, how it may be theorized and explained, and how it might be combated by legal and policy means.
Microstructuring of Glasses
As microstructured glass becomes increasingly important for microsystems technology, the main application fields include micro-fluidic systems, micro-analysis systems, sensors, micro-actuators and implants. And, because glass has quite distinct properties from silicon, PMMA and metals, applications exist where only glass devices meet the requirements. The main advantages of glass derive from its amorphous nature, the precondition for its - theoretically - direction-independent geometric structurability. Microstructuring of Glasses deals with the amorphous state, various glass compositions and their properties, the interactions between glasses and the electromagnetic waves used to modify it.
Microplastic in the Environment : Pattern and Process
This book examines global plastic pollution, an issue that has become a critical societal challenge with implications for environmental and public health. This volume provides a comprehensive, holistic analysis on the plastic cycle and its subsequent effects on biota, food security, and human exposure. Importantly, global environmental change and its associated, systems-level processes, including atmospheric deposition, ecosystem complexity, UV exposure, wind patterns, water stratification, ocean circulation, etc., are all important direct and indirect factors governing the fate, transport and biotic and abiotic processing of plastic particles across ecosystem types.
Micrometeorology
This book focuses on atmospheric processes which directly effect human environments within the lowest 100-1000 meters of the atmosphere over regions of only a few kilometers in extent. The book is the English translation of the second edition of the German book "Applied Meteorology – Micrometeorological Methods".
