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Molecular Pharmacognosy
This book discusses the application of molecular biology in resource science and authentication of traditional Chinese medicine (TCM). It also reviews the latest developments in pharmacognosy, introduces new perspectives and insights, discusses the hotspots and focuses in the field of molecular pharmacognosy, and predicts new directions of study. In the last five years, the technologies and scope of molecular pharmacognosy have constantly expanded and evolved. As such, this new edition includes extra content, such as the molecular phylogeography of medicinal plants, functional genome of medicinal plants, and synthetic biology of active compounds. Elucidating the concept, theory, and methodology of molecular pharmacognosy, it promotes the full use of the newly developed technologies and methodologies within the framework of molecular pharmacognosy to solve problems in the field.
Molecular Pathology of Gynecologic Cancer
This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. The volume begins with an explication of the editors’ hypothesis that cancer is mainly a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction. The following eleven chapters focus on specific issues in gynecologic cancers, including: a proposed model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, an overview of the pathology of endometrial cancer, molecular genetic aspects of endometrial carcinoma and cervical cancer, a natural history of Human Papilloma Virus (HPV) as it relates to cervical cancer, and hereditary issues in gynecologic cancers. The concluding chapter proposes and outlines a holistic approach to the treatment of female cancer patients.
Molecular Pathology in Clinical Practice
This book addresses all areas of molecular pathology clinical practice in a single text, including: molecular biology basics, genetics, infectious diseases, hematopathology, solid tumors, HLA typing, identity testing and laboratory management. This text will provide a comprehensive reference for molecular pathologists as well as the practicing molecular pathologist and trainees.
Molecular Parameters Indicating Adaptation to Mechanical Stress in Fibrous Connective Tissue
The present study pursues the hypothesis that local compressive force and the occurrence of cartilage-specific transformation processes within tendons and ligaments are directly correlated. In selected anatomical samples of human origin the distribution pattern of certain components of the extracellular matrix is assessed. Investigations are carried out at the extensor tendons of toes and fingers, at the transverse ligament of the atlas, at the transverse ligament of the acetabulum, and at the tendon of the superior oblique muscle and its trochlea. The molecular components of the extracellular matrix are detected with standardized immunohistochemical methods. The results show that certain molecules only occur due to compressive stress, others due to tensile stress. The molecular spectrum of the extracellular matrix allows qualifying conclusions to the mechanical situation of a given part of the tissue. The spatial expansion of the fibrocartilaginous adaptation zones in tendons and ligaments roughly corresponds with the zones subjected to compressive force; tensile stress alone does not result in a production of fibrocartilage.
Molecular Pain
This book focus on molecular and synaptic mechanisms for pain transmission, modulation and plasticity. Unlike traditional textbooks about pain, this book covers recent progress in neuroscience and relates these developments to the basic mechanisms of chronic pain. The book also discusses current pain medicine and alternative pain treatments such as acupuncture.
Molecular Organisation on Interfaces
This volume contains studies on the molecular organisation on interfaces and nanoparticles. The contributions were presented during the 40. General Meeting (Hauptversammlung) of the Kolloid-Gesellschaft in Potsdam in September 2001 and are related to the subject "Colloids and Life Science". Therefore, a diversity of papers were collected covering a large field: synthesis of polymer colloids, biominerals and nanoparticles, investigations on monolayers, lyotropic mesophases, polymeric surfactants, micellar transitions, supramolecular compounds for modifying polymers, solid particles for emulsion stabilisers, and adsorbents for odour control.
Molecular Neurosurgery with Targeted Toxins
Focuses on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.
Molecular microbiology of heavy metals
Molecular Microbiology of Heavy Metals includes chapters on allocation of metals in cells, metal transporter, storage and metalloregulatory proteins, cellular responses to metal ion stress, transcription of genes involved in metal ion homeostasis, uptake of essential metals, metal efflux and other detoxification mechanisms. Also discussed are metal bioreporters for the nanomolar range of concentration and tools to address the metallome. Chapters in the second part cover specific metals such as Fe, Mn, Cu, Ni, Co, Zn and Mo as key nutrient elements and Ag, As, Cd, Hg and Cr as toxic elements.
Molecular Mechanisms of Plant and Microbe Coexistence
Molecular Mechanisms of Plant and Microbe Coexistence presents studies on the complex and manifold interactions of plants and microbes at the population, genomics and proteomics level. The role of soil microbial diversity in enhancing plant health and plant microbe beneficial symbioses is discussed. Microbial communities are shown in the light of evolution. Main topics include genome coexistence and the functional genomics and proteomics of plant-associated microbes, which could form the basis for new environmentally benign strategies to combat infectious plant diseases and regulate plant growth. Further chapters focus on the role of signaling during the different stages of plant microbe coexistence, in symbiotic or pathogenic relationships, in quorum sensing and plant viral infections. Methods for studying the interactions in the root zone complement the book, which will certainly be of relevance in the practical application to agriculture, food security and for maintaining the balance of our ecosystems.
Molecular Mechanisms of Parasite Invasion
All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.
Molecular Mechanisms of Neurotransmitter Release
Within the complex neuronal network of the nervous system, neuron-to-neuron communication occurs mainly through chemical synapses, where the presynaptic nerve terminal releases neurotransmitters that control the function of postsynaptic neurons by acting on postsynaptic receptors. Recent decades have brought groundbreaking new developments and a wealth of knowledge to this field. In Molecular Mechanisms of Neurotransmitter Release, leading experts provide concise, up-to-date information on all major molecular mechanisms involved, with complete background information and figures and diagrams to further elucidate key concepts or experiments.Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release is sure to provide a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for all those who have a general interest in the ever-evolving field of neuroscience.
Molecular mechanisms of functional food
Provides information on the development and validation of functional foods towards their market and industrial application. It covers the available information on developments, efficacy, and testing and safety, while demonstrating the proven or potential effects of food on health and disease.
Molecular Mechanisms of Exocytosis
This book, written by recognized experts in the field aims at clarifying for a non-specialist audience the role of the key players in the exocytotic process not only in neuronal and endocrine cells but also in a variety of other relevant cell systems. The book represents a unique collection of up-to-date reviews that will introduce researchers and students to the forefront of this rapidly moving and fascinating field.
Molecular Mechanisms of Cancer
Cancer may constitute the most extensively studied functions constitute a second line of defense that disease entity of our time. Nevertheless, our com- protects against transforming defects in oncogenes prehension of the cellular and molecular pathology or tumor-suppressor genes and are here considered of malignant transformation is incomplete.
Molecular Mechanisms of Basal Cell and Squamous Cell Carcinomas
apid progress in the understanding of carcinogenesis and pathology of epitheUal skin cancer has led to new strategies for the prevention Rand treatment of these malignancies. The goal of this volume is to comprehensively cover in a highly readable overview our present knowledge of pathogenetic mechanisms and molecular biology of Basal Cell and Squamous Cell Carcinomas. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in epidemiology, histology, photobiology, immunology, cytogenetics, and molecular pathol ogy to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for clinicians and scientists interested in the biology of Basal Cell and Squamous Cell Carcinomas. The chapters are written by authors who are experts in their respective research areas, and I am gratefixl for their willingness to contribute to this book.
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
This book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies
Molecular Materials with Specific Interactions - Modeling and Design
One of the first requirements to initiate the molecular modeling of molecular materials is an accurate and realistic description of the electronic structure, intermolecular interactions and chemical reactions at microscopic and macroscopic scale. Therefore the first four chapters contain an extensive introduction into the latest theories of intermolecular interactions, functional density techniques, microscopic and mezoscopic modeling techniques as well as first-principle molecular dynamics.In the following chapters, techniques bridging microscopic and mezoscopic modeling scales are presented. The authors then illustrate various successful applications of molecular design of new materials, drugs, biocatalysts, etc. before presenting challenging topics in molecular materials design.
Molecular Marker Systems in Plant Breeding and Crop Improvement
Successful release of new and better crop varieties increasingly requires genomics and molecular biology. This volume presents basic information on plant molecular marker techniques from marker location up to gene cloning. The text includes a description of technical approaches in genome analysis such as comparison of marker systems, positional cloning, and array techniques in 19 crop plants. A special section focuses on converting this knowledge into general and specific breeding strategies, particularly in relation to biotic stress. Theory and practice of marker assisted selection for QTL, gene pyramiding and the future of MAS are summarized and discussed for maize, wheat, and soybean. Furthermore, approaches in silviculture on the examples of Fagus, Populus, Eucalyptus, Picea and Abies are presented. The volume ends with a comprehensive review of the patents relevant for using molecular markers and marker assisted selection.
Molecular Machines
The chapters in this volume describe bottom-up strategies and chronicle cutting-edge advances from several of the world’s leading laboratories engaged in the development of molecular machines.The Nobel Prize in Chemistry 2016 was awarded jointly to Jean-Pierre Sauvage, Sir J. Fraser Stoddart and Bernard L. Feringa "for the design and synthesis of molecular machines". Both Jean-Pierre Sauvage and Sir J. Fraser Stoddart have also contributed to this book.
Molecular Imaging II
The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is beeing addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.
