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Aromatase Inhibitors
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
Argumentation in multi-agent systems ; Vol. 4049 ; 2nd International Workshop, ArgMAS 2005, Utrecht, Netherlands, July 26, 2005, revised selected and invited papers
This book constitutes the thoroughly refereed post-proceedings of the Second International Workshop on Argumentation in Multi-Agent Systems held in Utrecht, Netherlands in July 2005 as an associated event of AAMAS 2005, the main international conference on autonomous agents and multi-agent systems. The 10 revised full papers presented together with an invited paper were carefully reviewed and selected from 17 submissions. The papers are organized in topical sections on foundations, negotiation, protocols, deliberation and coalition formation, and consensus formation.
Argumentation in multi-agent systems ; Vol. 3366 ; 1st International Workshop, ArgMAS 2004, New York, NY, USA, July 19, 2004, revised selected and invited papers
The theory of argumentation is a rich, interdisciplinary area of research lying across philosophy, communication studies, linguistics, and psychology (at least). Its techniques and results have found a wide range of applications in both t- oretical and practical branches of arti'cial intelligence and computer science. Several theories of argumentation with various semantics have been proposed in the literature. Multi-agent systems theory has picked up argument-inspired approaches and speci'cally argumentation-theoretic results from many di'erent areas. The community of researchers in argumentation and multi-agent systems is currently presented with a unique opportunity to integrate the various und- standings of argument into a coherent and core part of the functioning of - tonomouscompu...
Argumentation in multi-agent systems ; Third International Workshop, ArgMAS 2006, Hakodate, Japan, May 8, 2006, revised selected and invited papers
Argumentation provides tools for designing, implementing and analyzing sophisticated forms of interaction among rational agents. It has made a solid contribution to the practice of multiagent dialogues. Application domains include: legal disputes, business negotiation, labor disputes, team formation, scientific inquiry, deliberative democracy, ontology reconciliation, risk analysis, scheduling, and logistics.
Argumentation in multi-agent systems ; 4th International Workshop, ArgMAS 2007, Honolulu, HI, USA, May 15, 2007, revised selected and invited papers
This volume presents the latest developments in the growing area of research at the interface of argumentation theory and multiagent systems. Argumentation provides tools for designing, implementing and analyzing sophisticated forms of interaction among rational agents.
Applications of declarative programming and knowledge management ; 15th international conference on applications of declarative programming and knowledge management, INAP 2004, and 18th workshop on logic programming, WLP 2004, Potsdam, Germany, March 4-6, 2004, Revised Selected Papers
This volume contains a selection of papers presented at the 15th International Conference on Applications of Declarative Programming and Knowledge M- agement, INAP 2004, and the 18th Workshop on Logic Programming, WLP 2004, Declarative programming is an advanced paradigm for the modeling and solving of complex problems. This speci?cation method has become more and more attractive in recent years, Thetopicsoftheselectedpapersofthisyear’sjointconferenceconcentrateon three currently important ?elds: knowledge management and decision support, constraint programming and constraint solving, and declarative programming and Web-based systems.
Applications of Agent Technology in Traffic and Transportation
Building effective and user-friendly transportation systems is one of the big challenges for engineers in the 21st century. There is an increasing need to understand, model, and govern such systems at both the individual (micro) and the society (macro) level. Still, this raises significant technical problems, as transportation systems may contain thousands of autonomous, "intelligent" entities that need to be simulated and/or controlled. Therefore, traffic and transportation scenarios are extraordinarily appealing for Distributed Artificial Intelligence, and (multi-) agent technology in particular. This book gives an overview of recent advances in agent-based transportation systems. It includes both a state-of-the-art survey and reports on cutting-edge research in the field.
Applications and Innovations in Intelligent Systems XV ; Proceedings of AI-2007, the Twenty-seventh SGAI International Conference on Innovative Techniques and Applications of Artificial Intelligence
The papers in this volume are the refereed application papers presented at AI-2007, the Twenty-seventh SGAI International Conference on Innovative Techniques and Applications of Artificial Intelligence, held in Cambridge in December 2007.
Applications and Innovations in Intelligent Systems XIII ; Proceedings of AI-2005, the Twenty-fifth SGAI International Conference on Innovative Techniques and Applications of Artifical Intelligence
The papers in this volume present new and innovative developments in the field, divided into sections on Applied AI in Information Processing, Techniques for Applied AI, Industrial Applications and Medical Applications.This is the thirteenth volume in the Applications and Innovations series. The series serves as a key reference as to how AI technology has enabled organisations to solve complex problems and gain significant business benefit.
Applications and innovations in intelligent systems XII ; Proceedings of AI-2004, the Twenty-fourth SGAI International Conference on Innhovative Techniques and Applications of Artificial Intelligence
The papers in this volume are the refereed application papers presented at AI-2004, the Twenty-fourth SGAI International Conference on Innovative Techniques and Applications of Artificial Intelligence, held in Cambridge 2004. The papers present new and innovative developments in the field, divided into sections on Synthesis and Prediction, Scheduling and Search, Diagnosis and Monitoring, Classification and Design, and Analysis and Evaluation. This is the twelth volume in the Applications and Innovations series. The series serves as a key reference on the use of AI Technology to enable organisations to solve complex problems and gain significant business benefits. The Technical Stream papers are published as a companion volume under the title Research and Development in Intelligent Systems XXI.
Anti-viral metabolites from medicinal plants
Covers general concepts of anti-viral metabolites, classifications, ethnopharmacology, chemistry, clinical and preclinical studies focusing on different medicinal plants against various types of viral infections. Various plants have been used in medicine since ancient times and are known for their strong therapeutic effects. The book will describe potential antiviral properties of medicinal plants against a diverse group of viruses, and provide an insight to the potential plants possess for broad-spectrum antiviral effects against emerging viral infections.The book aims to target a broad audience including virologists, molecular biologist, microbiologist and scientists working with natural products as well as researchers, students, healthcare experts involved in pharmaceutical and medical field.
Antisense RNA Design, Delivery, and Analysis
This volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Anti-Obesity drugs
As a chronic and relapsing disease, obesity impairs metabolism and causes diabetes, cardiovascular diseases and cancer. Although behavioral modification is important for the treatment of obesity, it is difficult to achieve an ideal weight or sustain the process of long-term weight loss. Therefore, the obesity control guidelines strongly recommend lifestyle interventions along with medical treatment for patients who are overweight. There is sufficient evidence supporting that pharmacotherapy in combination with behavior-based interventions can result in significant weight loss and improvement of the health.
Antimalarial natural products
Begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type.
Antimalarial medicinal plants
Malaria continues to affect a large population of the world, especially in third world countries. The spread of drug-resistant parasites demonstrates the need for antimalarial agents with various modes of action. The search for remedies derived from medicinal plants for the treatment of malaria is reliant on accurate ethnobotanical and ethnopharmacological information obtained from traditional medical practitioners. Antimalarial Medicinal Plants provides information on bioactive compounds and therapeutic potentials of several antimalarial plant species found around the globe. This book evaluates these plant species with respect to their biology, diversity, distribution, and pharmacological values.
Antifouling Paint Biocides
This volume describes the state-of-the-art advances regarding antifouling paint biocides and provides thorough evaluation of research and information on major topics such as occurrence and levels, environmental fate, analytical techniques and methods for the monitoring and control, environmental modeling, ecotoxicological effects and risk assessment placing emphasis on the knowledge acquired over the last 10 years. The contamination of the aquatic environment by antifouling compounds has been a topic of increasing importance during the last few years. The major classes of antifouling active biocides are discussed including the old-fashioned organotin compounds, the modern organic booster biocides and the promising naturally occurring antifoulant products. Therefore, the reader will get a balanced view of this developing field. Chapters were written by leading experts in their field who critically surveyed all the major areas of progress. This volume is an important resource and can constitute a good grounding in the field of antifouling paint biocides.
Antidiabetic plants for drug discovery pharmacology, secondary metabolite profiling, and ingredients with insulin mimetic activity
Takes an in-depth look at the potential pharmacological applications of 11 important antidiabetic plants, examining their antihyperglycemic, hypoglycemic, and anti-lipidemic properties along with current genome editing research perspectives. Plant natural products, or phytoconstituents, are promising candidates for antidiabetic pharmacological actions. The phytoconstituents, such as fl avonoids, terpenoids, saponins, carotenoids, alkaloids and glycosides, play vital roles in the current and future potent antidiabetic drug development programs. Each chapter reviews a particular plant with antidiabetic properties, explaining the therapeutic aspects, its active antidiabetic compounds, and relevant genome editing technology.
Antidiabetic medicinal plants and herbal treatments
Diabetes is a chronic condition associated with metabolic disorder. Persons suffering from diabetes have shown accelerated levels of blood sugar which often harms the heart, blood vessels, eyes, kidneys, and nerves. Over the past few decades, the prevalence of diabetes has been progressively increasing. Synthetic drugs are used to treat diabetic patients to help control the disorder, but it is shown that numerous medicinal plants and herbal drugs are widely used in several traditional systems of medicine to prevent and treat diabetes. They are reported to produce beneficial effects in combating diabetes and alleviating diabetes-related complications. These plants contain phtyonutrients and phytoconstituents demonstrating protective or disease preventive properties. In many developing countries, herbal drugs are recommended by traditional practitioners for diabetes treatment because the use of synthetic drugs is not affordable.
Antidepressants Beyond Depression, and Into Bacteria
Antidepressants are one of the most predominant drug groups in the pharmaceutical world, primary care units and the general public. Their original use was majorly for the treatment of depression along with other mental disorders. Today, antidepressant consume over 20% of the medical prescriptions and healthcare plans due to their recently discovered applications outside the psychiatry field. Due to the alarming rise of antibiotic resistance and the slow pace of new drug discovery, the world has been searching frantically for new or alternative drugs with antibacterial activity. Repurposing already FDA- approved drugs for uses that are off-label has become an important preposition in the pharmacy world due to its availability, low risk and low cost.
Anticoagulants
Anticoagulant are drugs that, when added to blood, prevents it from clotting. It does this by suppressing the synthesis or function of various clotting factors that are normally present in the blood. These drugs are frequently used to prevent the formation of blood clots (thrombi) in the veins or arteries or the enlargement of a clot that is circulating in the bloodstream. Anticoagulants are very effective in preventing life-threatening conditions...
