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Personalized medicine
The introduction of personalized medicine (PM) has been a milestone in the history of medical therapy, because it has revolutionized the previous approach of treating the disease with that of treating the patient. It is known today that diseases can occur in different genetic variants, making specific treatments of proven efficacy necessary for a given endotype. There is a growing attention towards personalized medicine. This is led by a fundamental shift from the ‘one size fits all’.. (Every year in the USA 2 million people die due to adverse drug effects, Drug efficacy is only in 60 % of the population - Other 40 % have poor drug effects or no effect at all ) paradigm for treatment of patients with conditions or predisposition to diseases, to one that embraces novel approaches, such as tailored target therapies, to achieve the best possible outcomes.
Periphery and Small Ones Matter : Interplay of Policy and Social Capital
This book analyzes the dualism and inequality insofar as how it is manifested in interregional disparity and small enterprises. Using the case of Indonesia, the author considers how the general direction of policy should be to mitigate the effects of agglomeration forces leading towards concentration, and exploit the same forces by encouraging small businesses to operate in a cluster for collective action. The book addresses these issues by focusing on the role of interactions between policies and institutions, of which social capital is an important part.
Pediatric Bone and Soft Tissue Sarcomas
The field of pediatric bone and soft tissue sarcomas has experienced a gradual but surprising transformation. Fundamental discoveries in the molecular biology of disease, recent breakthroughs in diagnostic imaging, and revolutionary surgical techniques have created unprecedented synergies and a refreshing vision with which to approach the diagnosis and treatment of these pediatric tumors. This book highlights the paths leading to the emergence of such a new vision and presents salient concepts in epidemiology, novel tools in imaging and molecular biology, and principles of drug development as the scaffold to understanding the pathophysiology and treatment of pediatric sarcomas. The book is aimed at providing an up-to-date comprehensive reference text which articulates a multidisciplinary approach for the diagnosis and treatment of each of these often challenging diseases.
Patterns and Interfaces in Dissipative Dynamics
Gives in-depth descriptions of analytical methods elucidating the complex evolution of nonlinear dissipative systems, and brings the reader to the forefront of current research. The introductory chapter on the theory of dynamical systems is written with a view to applications of its powerful methods to spatial and spatio-temporal patterns. It is followed by two chapters treating moving interfaces, based largely on reaction-diffusion and phase-separating systems. The following two chapters on amplitude equations for patterns and waves describe universal phenomena generated by representative equations which can be derived for a variety of non-equilibrium systems originating in fluid mechanics, physical chemistry or nonlinear optics.
Pattern Language for Game Design
Builds on the revolutionary work of architect Christopher Alexander to show students, teachers, and game development professionals how to derive best practices in all aspects of game design. Using a series of practical, rigorous exercises, designers can observe and analyze the failures and successes of the games they know and love to find the deep patterns that underlie good design. From an in-depth look at Alexander's work, to a critique of pattern theory in various fields, to a new approach that will challenge your knowledge and put it to work, this book seeks to transform how we look at building the interactive experiences that shape us
Paths to the Emerging State in Asia and Africa
This book addresses the issue of how a country, which was incorporated into the world economy as a periphery, could make a transition to the emerging state, capable of undertaking the task of economic development and industrialization. It offers historical and contemporary case studies of transition, as well as the international background under which such a transition was successfully made (or delayed), by combining the approaches of economic history and development economics. Its aim is to identify relevant historical contexts, that is, the ‘initial conditions’ and internal and external forces which governed the transition. It also aims to understand what current low-income developing countries require for their transition. Three economic driving forces for the transition are identified. They are: (1) labor-intensive industrialization, which offers ample employment opportunities for labor force; (2) international trade, which facilitates efficient international division of labor; and (3) agricultural development, which improves food security by increasing supply of staple foods.
Parameterized and exact computation ; 3rd International Workshop, IWPEC 2008, Victoria, Canada, May 14-16, 2008. Proceedings
Constitutes the refereed proceedings of the Third International Workshop on Parameterized and Exact Computation, IWPEC 2008, held in Victoria, Canada ,The 17 revised full papers presented together with 3 invited lectures were carefully reviewed and selected from 32 submissions. The topics addressed cover research in all aspects of parameterized and exact computation and complexity, including but not limited to new techniques for the design and analysis of parameterized and exact algorithms, parameterized complexity theory, relationship between parameterized complexity and traditional complexity classifications, applications of parameterized computation, implementation and experiments, high-performance computing and fixed-parameter tractability.
Parameter Setting in Evolutionary Algorithms
One of the main difficulties of applying an evolutionary algorithm (or, as a matter of fact, any heuristic method) to a given problem is to decide on an appropriate set of parameter values. Typically these are specified before the algorithm is run and include population size, selection rate, operator probabilities, not to mention the representation and the operators themselves. This book gives the reader a solid perspective on the different approaches that have been proposed to automate control of these parameters as well as understanding their interactions. The book covers a broad area of evolutionary computation, including genetic algorithms, evolution strategies, genetic programming, estimation of distribution algorithms, and also discusses the issues of specific parameters used in parallel implementations, multi-objective evolutionary algorithms, and practical consideration for real-world applications. It is a recommended read for researchers and practitioners of evolutionary computation and heuristic methods.
Parallel processing and applied mathematics ; 7th International Conference, PPAM 2007, Gdansk, Poland, September 9-12, 2007 Revised Selected Papers
Constitutes the thoroughly refereed post-conference proceedings of the 7th International Conference on Parallel Processing and Applied Mathematics, PPAM 2007, held in Gdansk, Poland, in September 2007.The 63 revised full papers of the main conference presented together with 85 revised workshop papers were carefully reviewed and selected from over 250 initial submissions. The papers are organized in topical sections on parallel/distributed architectures and mobile computing, numerical algorithms and parallel numerics, parallel and distributed non-numerical algorithms, environments and tools for as well as applications of parallel/distributed/grid computing, evolutionary computing, meta-heuristics and neural networks.
Parallel Processing and Applied Mathematics ; 4th International Conference, PPAM 2001 Naleczow, Poland, September 9-12, 2001 Revised Papers
Constitutes the thoroughly refereed post-proceedings of the 4th International Conference on Parallel Processing and Applied Mathematics, PPAM 2002, held in Naleczow, Poland, in September 2001. The 101 papers presented were carefully reviewed and improved during two rounds of reviewing and revision. The book offers topical sections on distributed and grid architectures, scheduling and load balancing, performance analysis and prediction, parallel non-numerical algorithms, parallel programming, tools and environments, parallel numerical algorithms, applications, and evolutionary computing and neural networks.
Parallel problem solving from nature – PPSN XVI ; 16th International conference, PPSN 2020, Leiden, The Netherlands, September 5-9, 2020, Proceedings, Part II
Constitutes the refereed proceedings of the 16th International Conference on Parallel Problem Solving from Nature, PPSN 2020, held in Leiden, The Netherlands, in September 2020. The 99 revised full papers were carefully reviewed and selected from 268 submissions. The topics cover classical subjects such as automated algorithm selection and configuration; Bayesian- and surrogate-assisted optimization; benchmarking and performance measures; combinatorial optimization; connection between nature-inspired optimization and artificial intelligence; genetic and evolutionary algorithms; genetic programming; landscape analysis; multiobjective optimization; real-world applications; reinforcement learning; and theoretical aspects of nature-inspired optimization.
Parallel Problem Solving from Nature – PPSN XVI ; 16th International Conference, PPSN 2020, Leiden, The Netherlands, September 5-9, 2020, Proceedings, Part I
Constitutes the refereed proceedings of the 16th International Conference on Parallel Problem Solving from Nature, PPSN 2020, held in Leiden, The Netherlands, in September 2020. The 99 revised full papers were carefully reviewed and selected from 268 submissions. The topics cover classical subjects such as automated algorithm selection and configuration ; Bayesian- and surrogate-assisted optimization ; benchmarking and performance measures ; combinatorial optimization; connection between nature-inspired optimization and artificial intelligence ; genetic and evolutionary algorithms ; genetic programming; landscape analysis ; multiobjective optimization ; real-world applications ; reinforcement learning ; and theoretical aspects of nature-inspired optimization.
Parallel Problem Solving from Nature - PPSN X ; 10th International Conference, Dortmund, Germany, September 13-17, 2008. Proceedings
Constitutes the refereed proceedings of the 10th International Conference on Parallel Problem Solving from Nature, PPSN 2008, held in Dortmund, Germany, in September 2008.The 114 revised full papers presented were carefully reviewed and selected from 206 submissions. The conference covers a wide range of topics, such as evolutionary computation, quantum computation, molecular computation, neural computation, artificial life, swarm intelligence, artificial ant systems, artificial immune systems, self-organizing systems, emergent behaviors, and applications to real-world problems. The paper are organized in topical sections on formal theory, new techniques, experimental analysis, multiobjective optimization, hybrid methods, and applications.
Parallel Problem Solving from Nature - PPSN IX ; 9th International Conference, Reykjavik, Iceland, September 9-13, 2006, Proceedings
We received 255 paper submissions this year. After an extensive peer review process involving more than 1000 reviews, the programme committee selected the top 106 papers for inclusion in this volume and, of course, for presentation at the conference. This represents an acceptance rate of 42%. The papers included in this volume cover a wide range of topics, from e- lutionary computation to swarm intelligence and from bio-inspired computing to real-world applications. They represent some of the latest and best research in evolutionary and natural computation. Following the PPSN tradition, all - pers at PPSN IX were presented as posters. There were 7 sessions: each session consisting of around 15 papers. For each session, we covered as wide a range of topics as possible so that participants with di?erent interests could ?nd some relevant papers in every session.
Parallel Evolutionary Computations
Focuses on the aspects related to the parallelization of evolutionary computations, such as parallel genetic operators, parallel fitness evaluation, distributed genetic algorithms, and parallel hardware implementations, as well as on their impact on several applications.
Paleopalynology ; 2nd ed.
Paleopalynology, second edition, provides profusely illustrated treatment of fossil palynomorphs, including spores, pollen, dinoflagellate cysts, acritarchs, chitinozoans, scolecodonts, and various microscopic fungal and algal dispersal bodies. The book serves both as a student text and general reference work. Palynomorphs yield information about age, geological and biological environment, climate during deposition, and other significant factors about the enclosing rocks. Extant spores and pollen are treated first, preparing the student for more difficult work with fossil sporomorphs and other kinds of palynomorphs. Recognizing that palynomorphs occur together in rocks because of chemical robustness and stratigraphic distribution, not biological relationship, the central sections are organized stratigraphically. Among many other topics presented are the sedimentation and geothermal alteration of palynomorphs, and palynofacies analysis. An appendix describes laboratory methods. The glossary, bibliographies and index are useful tools for study of the literature.
Paleomicrobiology : Past Human Infections
Features the methods and main achievements in this emerging field of research at the intersection of microbiology and evolution, history and anthropology. New molecular approaches have already provided exciting results, such as confirmation of a single biotype of Yersinia pestis as the causative agent of historical plague pandemics, and the closer proximity of Mycobacterium tuberculosis from ancient skeletons to modern strains than to Mycobacterium bovis, shedding new light on the evolution of major human pathogens and pathogen–population relationships. Firm microbiological diagnoses also provide historians and anthropologists with new data on which to base evaluation of past epidemics.
Pain in Children : A Practical Guide for Primary Care
Advances over the past two decades have enabled physicians to revolutionize the manner in which they can assess and manage children’s pain. Thirty years ago it was thought that young children did not experience pain and therefore it was not necessary to treat it. Today professionals from a variety of disciplines have contributed data that have revolutionized medical perspectives. Technological advances now enable doctors to treat acute pain in fetuses, premature neonates, infants, toddlers, children, and adolescents with increasing precision and efficacy. Research highlighting the context of chronic pain has moved them away from a mind-body dichotomy and toward an integrated, holistic perspective that leads to substantial improvement in children’s adaptive functioning as well as subjective discomfort.
PACS : A Guide to the Digital Revolution
PACS: A Guide to the Digital Revolution, second edition, provides the reader with a comprehensive overview of this blossoming technology. With contributions from leaders in the field of PACS, this user-friendly guide addresses the introductory concepts, computing fundamentals, advanced imaging technologies, and future opportunities. It also offers invaluable concepts and tools that facilitate the financial evaluation of PACS, making it a great resource for those looking to plan for PACS implementation, assess institutional needs, write an RFP, and compare vendors' quotes.
Outer Magnetospheric Boundaries : Cluster Results
When the stream of plasma emitted from the Sun (the solar wind) encounters Earth's magnetic field, it slows down and flows around it, leaving behind a cavity, the magnetosphere. The magnetopause is the surface that separates the solar wind on the outside from the Earth's magnetic field on the inside. Because the solar wind moves at supersonic speed, a bow shock must form ahead of the magnetopause that acts to slow the solar wind to subsonic speeds. Magnetopause, bow shock and their environs are rich in exciting processes in collisionless plasmas, such as shock formation, magnetic reconnection, particle acceleration and wave-particle interactions. They are interesting in their own right, as part of Earth's environment, but also because they are prototypes of similar structures and phenomena that are ubiquitous in the universe, having the unique advantage that they are accessible to in situ measurements. The boundaries of the magnetosphere have been the target of direct in-situ measurements since the beginning of the space age. But because they are constantly moving, changing their orientation, and undergoing evolution, the interpretation of single-spacecraft measurements has been plagued by the fundamental inability of a single observer to unambiguously distinguish spatial from temporal changes. The boundaries are thus a prime target for the study by a closely spaced fleet of spacecraft. Thus the Cluster mission, with its four spacecraft in a three-dimensional configuration at variable separation distances, represents a giant step forward. The present 20th volume of the ISSI Space Science Series represents the first synthesis of the exciting new results obtained in the first few years of the Cluster mission.
