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Empirical Research within Resource-Based Theory : A Meta-Analysis of the Central Propositions
Katja Nothnagel evaluates this growing body of empirical research in resource-based theory. She starts out by deriving six central propositions and then examines how these propositions have been tested empirically. Over 190 empirical resource-based papers are identified. The results of this work are evaluated through a narrative review, vote counting as well as the use of a meta-analysis. The results suggest that substantial progress has been made within the empirical part of RBT: (a) various operationalization examples on the propositions’ central constructs prove that testing RBT propositions is possible; (b) vote counting results indicate an overall positive significant impact of resources on performance with negligible results in the opposite direction of the theory; and (c) meta-analysis results show significant positive relationships. The author concludes, however, that more research is needed regarding the factor market conditions and the operationalization of resource conditions.
Emerging Topics in Heat and Mass Transfer in Porous Media : From Bioengineering and Microelectronics to Nanotechnology
This book provides a unique collection of articles reviewing the state-of-the-art in the field of heat and mass transfer in porous media with particular emphasis to emerging technologies, from bioengineering and bio-tissues and microelectronics to nanotechnology.
Electron crystallography : Novel approaches for structure determination of nanosized materials
During the last decade we have been witness to several exciting achievements in electron crystallography. This includes structural and charge density studies on organic molecules complicated inorganic and metallic materials in the amorphous, nano-, meso- and quasi-crystalline state and also development of new software, tailor-made for the special needs of electron crystallography. This volume comprises the proceedings of the NATO Advanced Study Institute on Electron Crystallography: Novel Approaches for Structure Determination of Nanosized Materials, Erice, Italy, 10 - 24 June 2004
Electrochemical processes and corrosion in reinforced concrete
Some reinforced concrete structures prematurely corrode as they age, with significant financial implications, but it is not immediately clear why some are more durable than others. This book looks at the various mechanisms for corrosion and how what seemed to be a relatively simple matter has become more complex the further it is understood due to the properties of concrete, steel and the way reinforced concrete structures are constructed. The significance of electrochemical processes is identified with recent research using new technology discussed.
Electroactive Polymers for Robotic Application : Artificial Muscles and Sensors
Electroactive polymers (EAPs) respond to electrical stimulation with large deformations. They are dynamic actuators which have attracted attention from an interdisciplinary audience of engineers and scientists. An enabling EAP technology is emerging which attempts to imitate the properties of natural muscle and which, as a result, can perform a unique function in a variety of biologically-inspired robotics applications. Electroactive Polymers for Robotics Applications covers the fundamental properties, modelling and demonstration of EAPs in robotic applications, focusing particularly on artificial muscles and sensors. Ionic Polymer–Metal Composite Actuators and Dielectric Elastomers are discussed within the book with chapters on their properties and their uses in robotics applications.
Electrical Resistivity of Thin Metal Films
The aim of the book is to give an actual survey on the resistivity of thin metal and semiconductor films interacting with gases. We discuss the influence of the substrate material and the annealing treatment of the films, presenting our experimental data as well as theoretical models to calculate the scattering cross section of the conduction electrons in the frame-work of the scattering hypothesis.
EGFR Signaling Networks in Cancer Therapy
EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first of which probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis.
Economic evaluations in exploration
This textbook, now in its second English edition, is originally a translation of the G- man textbook “Rechnen für Lagerstättenkundler und Rohstoffwirtschaftler, Teil 1”, also translated into the Chinese and Russian languages. Compared to the previous English and German editions the chapters have been updated with new examples and in many cases amended. The textbook is intended for the economic geologist who deals with the evaluation of deposits at an early stage of development. Once an exploration project has reached the feasibility stage, the exact calculations that are necessary for a comprehensive te- nical and economic assessment will be performed by a team of geologists, mining engineers, metallurgists, and economists. In the early stages of exploration, however, any evaluator of deposits must be able to cover the whole spectrum himself. Since only order of magnitude parameters are available at this early stage, the c- culations can only yield order of magnitude results.
Ecological and Health Effects of Building Materials
Deals with the present adverse effects of using precarious building materials on the ecology and human health. Also, the detailed discussions on the novel and greener construction materials and their utilization as an alternative to the conventional harmful existing methods and materials are also presented in the subsequent chapters. This book helps to fill the research gaps in the existing prior-art knowledge in the field of sustainable construction and green building materials and methods giving due importance to ecology and health, specifically to the fields of sustainable structural engineering, sustainable geotechnical engineering, sustainable road engineering, etc.
Early Nutrition and its Later Consequences : New Opportunities; Perinatal Programming of Adult Health - EC Supported Research
Health problems such as hypertension, tendency to diabetes, obesity, blood lipids, vascular disease, bone health, behaviour and learning and longevity may be ‘imprinted’ during early life. This process is defined as ‘programming’ whereby a nutritional stimulus operating at a critical, sensitive period of pre and postnatal life imprints permanent effects on the structure, physiology and metabolism. For this reason, academics and industry set-up the EC supported Scientific Workshop -Early Nutrition and its Later Consequences: New Opportunities. The prime objective of the Workshop was to generate a sound exchange of the latest scientific developments within the field of early nutrition to look for opportunities for new preventive health concepts. Further, a closer look was taken at the development of food applications which could provide (future) mothers and infants with improved nutrition that will ultimately lead to better future health. The Workshop was organised by the Dept. of Pediatrics, University of Munich, Germany in collaboration with the Danone Institutes and the Infant Nutrition Cluster, a collaboration of three large research projects funded by the EU.
Dynamic Magma Evolution
Understanding the magmatic processes responsible for the chemical and textural signatures of volcanic products and igneous rocks is crucial for monitoring, forecasting, and mitigating the impacts of volcanic activity. Dynamic Magma Evolution is a compilation of recent geochemical, petrological, physical, and thermodynamic studies. It combines field research, experimental results, theoretical approaches, unconventional and novel techniques, and computational modeling to present the latest developments in the field.
Drugs and Poisons in Humans : A Handbook of Practical Analysis
At the beginning of the book, general topics are addressed, including instructions on h- dling biological materials, measurement of drugs in alternative specimens, and guidance on resolving analytical problems that may occur. T ere are discussions of extraction modalities and detection methodologies and how to select these appropriately based on the physioche- cal characteristics of the drug. Analysis of specif c classes of drugs and relevant metabolites are covered in subsequent chapters.
Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
Drug target selection and validation
Focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis. Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis. Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided. The book concludes with a chapter on chemical and structural databases.
Drug Metabolism: Current Concepts
The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development.
Drug Metabolism, Pharmacokinetics and Bioanalysis
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug-drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters.
Drug interactions in infectious diseases : Mechanisms and models of drug interactions
Provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development
Drug disposition and pharmacokinetics : Principles and applications for medicine, toxicology and biotechnology
Delivers an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics.
Drug delivery technology : Herbal bioenhancers in pharmaceuticals
Bioenhancers have been used in Ayurveda historically and are now being investigated for their pharmacological effi cacy. Herbal bioenhancers work on the gastrointestinal tract to improve absorption and drug bioavailability by acting on the drug metabolic process. Many herbal drugs show low activity due to their poor lipid solubility or improper molecular size. Piperine, gingerol, naringin, quercetin, niaziridin, glycyrrhizin, allicin, curcumin, genistein and others are able to enhance the bioavailability of active pharmaceuticals. This book details various facets of herbal bio-enhancers in a single comprehensive text.
Drug Delivery Systems for Metabolic Disorders
Covers recent developments in advanced drug delivery systems in various metabolic disorders, including disturbances in protein, lipid, carbohydrate and hormone metabolism and lysosomal and mitochondrial disorders. It provides a brief introduction to metabolic disorders, along with a focus on the current landscape and trends in understanding disease pathology using different in vitro and in vivo models required for clinical applications and developments of new therapeutics.
