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Drug Delivery Approaches : Perspectives from Pharmacokinetics and Pharmacodynamics
Delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes.
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
Drawing architecture and the Urban
Provides an instrumental approach to drawing, especially computer-generated drawings; it outlines how drawings should be used to convey clear and analytical information in the process of design, as well as the communication and discussion of a project. In depth examples are provided how to communicate effectively. The final section demonstrates how to transform case-studies, directly connecting an analytical approach with the design process.
Dissecting the Molecular Anatomy of Tissue
The book provides an updated overview of molecular analysis of human tissues, and the impact this analysis has on diagnosis and prognosis of human diseases. Special emphasis is placed on human cancer and the future directions of the field. Methods of handling clinical tissue samples, including the impact of handling on subsequent molecular analysis, are also discussed. In addition, detailed protocols for molecular analysis of DNA, RNA and protein, with special emphasis on molecular analysis of highly complex human tissue samples containing mixtures of cell populations, are provided.
Directory of microbicides for the protection of materials : A handbook
This edition is divided into two parts. In Part One 23 contributions of worldwide selected experts present extensively diversified information about: -Microbicides with regard to the relationship between chemical structure and mode of action and activity, -Research and development in consideration of registration procedures,Legislative aspects,The use of microbicides in the major application areas (18) which are described in detail.The Microbicide Data is organized into 21 substance classes (e.g. alcohols, aldehydes, acids, amides, etc.) and collected in Part Two.
Directions in strong motion instrumentation ; Proceedings of the NATO SFP Workshop on Future Directions in Instrumentation for Strong Motion and Engineering Seismology, Kusadasi, Izmir, May 17-21, 2004
This book, which contains papers by invited authorities, represents a unique interaction between seismologists and earthquake engineers who examine issues of mutual concern in an overlapping area of major interest. The papers have been grouped around three major areas. -Seismic Hazard and Extreme Motions -Engineering Uses of Strong Motion Seismograms -Arrays and Observations.
Directing the Story : Professional Storytelling and Storyboarding Techniques for Live Action and Animation
You will learn classic visual storytelling techniques such as conveying meaning with images and directing the viewer's eye. Glebas also teaches how to spot potential problems before they cost time and money, and he offers creative solutions on how to solve them. Uses the classic story of '1001 Arabian Nights' to show how to storyboard stories that will engage an audience's attention and emotions. With 1001 drawings in graphic novel format plus teaching concepts and commentary. All of the storyboarding examples have a real project context rather to engage a very visual audience on their own terms and teaches through demonstration
Directed Metallation
a new chelation-assisted methodology has been developed not only for controlling regio- and stereoselectivity of reactions, but also for accelerating reactions. In particular, chelation-methodology has been utilized as a new activation method, in which a carbon-metal bond is generated directly from a C-H bond; a reaction rarely achieved using conventional methods. A wide variety of catalytic functionalization reactions of C-H bonds by the utilization of a chelation, have been developed recently and are comprehensively discussed in this book by leading experts. In addition, new approaches to directed hydrometalation and directed carbometalation as a key step are also discussed. A unique stereo- and regioselective hydroformylation has been developed through the utilization of directed hydrometalation.
Direct Transistor-level Layout for Digital Blocks
The essential flaw in prior efforts is an over-reliance on geometric assumptions from large-scale cell-based layout algorithms. Individual transistors may seem simple, but they do not pack as gates do. Algorithms that ignore these shape-level issues suffer the consequences when thousands of devices are poorly packed. The approach described in this book can pack devices much more densely than a typical cell-based layout
Direct Methods in the Calculus of Variations
Studies vectorial problems in the calculus of variations and quasiconvex analysis. It is a new edition of the earlier book published in 1989 and has been updated with some new material and examples added. This monograph will appeal to researchers and graduate students in mathematics and engineering.
Direct Democracy in Europe : Developments and Prospects
The initiative and referendum process offers extra channels of participation and can serve as an important supplementary institution in representative democratic systems. This first volume of the new series Direct Democracy in Modern Europe features sixteen systematic and broadly empirical approaches to the study of modern direct democracy within the context of European politics including - system contexts and effects of the initiative and referendum process - theoretical approaches and basic values in modern direct democracy - the quality and institutional design of direct democratic mechanisms - aspects of information and communication - institutional performance and economic effectiveness - transnational challenges and the development of direct democracy in Europe
Direct and Large-Eddy Simulation VI ; Proceedings of the Sixth International ERCOFTAC Workshop on Direct and Large-Eddy Simulation, held at the University of Poitiers, September 12-14, 2005
this workshop addressed numerous theoretical and physical aspects of transitional and turbulent flows. At an applied level it contributed to the solution of problems related to energy production, transportation and the environment. Since the prediction and analysis of fluid turbulence and transition continues to challenge engineers, mathematicians and physicists, DLES-6 covered a large range of topics, from the more technical ones like numerical methods, initial and inflow conditions, the coupling of RANS and LES zones, subgrid and wall modelling to topics with a stronger focus on flow physics such as aero-acoustics, compressible and geophysical flows, flow control, multiphase flow and turbulent combustion, to quote only a few.
Direct and inverse Sturm-Liouville problems : A method of solution
This book provides an introduction to the most recent developments in the theory and practice of direct and inverse Sturm-Liouville problems on finite and infinite intervals. A universal approach for practical solving of direct and inverse spectral and scattering problems is presented, based on the notion of transmutation (transformation) operators and their efficient construction. Analytical representations for solutions of Sturm-Liouville equations as well as for the integral kernels of the transmutation operators are derived in the form of functional series revealing interesting special features and lending themselves to direct and simple numerical solution of a wide variety of problems.
Direct and indirect resin composite veneers
Re-establishing a patient’s lost dental asthetic appearance is one of the most important topics for contemporary dentistry.New treatment materials and methods have been coming on the scene, day by day, in order to achieve such an aim. Most dentists prefer more conservative and aesthetic approaches. Laminate veneers are restorations which are envisioned to correct existing abnormalities, esthetic deficiencies and discolorations. Laminate veneer restorations may be processed in two different ways: direct or indirect. Direct resin composite veneers are one of the most commonly used restorations in the treatment of poor esthetics in anterior teeth presenting unsatisfactory colour and shape, defective restorations, slight misalignment and fractures.
DiPiro’s pharmacotherapy : A pathophysiologic approach
It is this in-depth knowledge of pharmacotherapy, combined with the clinical experience gained through postgraduate training in direct patient care practice, that allows the pharmacist to be the "medication therapy expert" on the healthcare team and to proactively address medication-related problems.It is provides knowledge necessary to prevent, identify, and manage disease and medication-related problems
Digital Watermarking ; Vol. 3710 ; 4th International Workshop, IWDW 2005, Siena, Italy, September 15-17, 2005, Proceedings
We are delighted to welcome the attendees of the Fourth International Wo- shop on Digital Watermarking (IWDW). Watermarking continues to generate strong academic interest. Commercialization of the technology is proceeding at a steadypace. We haveseen watermarkingadoptedfor DVD audio.Fingerpri- ing technology was successfully used to determine the source of pirated video material. Furthermore, a number of companies are using watermarking as an enabling technology for broadcast monitoring services. Watermarking of digital cinema contentis anticipated. Future applications may also come from areas- related to digital rights management. For example, the use of watermarking to enhance legacy broadcast and communication systems is now being considered. IWDW 2005 o?ers an opportunity to re?ect upon the state of the art in digital watermarking as well as discuss directions for future research and applications. This year we accepted 31 papers from 74 submissions. This 42% acceptance rate indicates our commitment to ensuring a very high quality conference.
Digital twin : Architectures, networks, and applications
Offers comprehensive, self-contained knowledge on digital twin (DT), which is a very promising technology for achieving digital intelligence in the next-generation wireless communications and computing networks. DT is a key technology to connect physical systems and digital spaces in Metaverse. The objectives of this book are to provide the basic concepts of DT, to explore the promising applications of DT integrated with emerging technologies, and to give insights into the possible future directions of DT. For easy understanding, this book also presents several use cases for DT models and applications in different scenarios. The book starts with the basic concepts, models, and network architectures of DT. Then, we present the new opportunities when DT meets edge computing, Blockchain and Artificial Intelligence, and distributed machine learning (e.g., federated learning, multi-agent deep reinforcement learning).
Digital Technologies in Construction Engineering : Selected Papers
Includes the latest advances, innovations, and applications in the field of construction engineering, as presented by researchers and engineers at the Digital Technologies in Construction Engineering conference, held in Belgorod, Russia, on June 8-9, 2021. It covers highly diverse topics, including industrial and civil construction, building materials; environmental engineering and protection; sustainability; structure safety and special construction structures. The contributions, which were selected by means of a rigorous international peer-review process, highlight numerous exciting ideas that will spur novel research directions and foster multidisciplinary collaborations.
Digital synthesizers and transmitters for software radio
By programming the digital synthesizers and transmitters, adaptive channel bandwidths, modulation formats, frequency hopping and data rates are easily achieved. Techniques such as digital predistortion for power amplifier linearization, digital compensation methods for analog I/Q modulator nonlinearities and digital power control and ramping are presented in this book
Digital marketing
Covers general topics of digital marketing and seven chapters focused on how to use marketing theory and concepts, in combination with digital marketing tools, to “do digital marketing.” grounded in marketing theory and concepts taking a strategic and analytical approach with global examples - relevant chapters designed through “thinking about global digital marketing” “legal and ethical issues” “privacy and security considerations” and “value creation” latest digital marketing tools with emphasizing current marketing trends and showcasing how tools should be applied - hands-on digital marketing exercises, including mocking up a website (using tools, not programming), creating google search ad campaigns, creating social media and community content with additional direction toward industry certifications such as google ads, social media, and email marketing.
