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Drugs, the brain, and behavior : The pharmacology of therapeutics and drug use disorders
Provides a comprehensive overview of the brain and explores the clinical and pharmacological issues surrounding drug abuse and dependence. Dr Brick provides definitions, historic discoveries about the nervous system, and original, eye-catching illustrations to discuss the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs. Topics include: how psychoactive drugs affect cognition, behavior, and emotion; the brain/behavior relationship; the specific effects of major addictive and psychoactive drug groups; new definitions and thinking about abuse and dependence; and the medical uses of drugs, such as cannabinoids. A new chapter on biobehavioral markers explores how markers can guide the clinician in the diagnosis of some disorders. This book offers a quick reference guide which uses a balance of instruction, illustrations, tables, and formulas, that will give you a broad, lasting introduction to this intriguing subject.
Drugs and nutrients : The interactive effects
Devoted to the effects of food and of nutrient intake on the disposition of foreign compounds, and discusses effects of drugs on nutrition. It is intended for nutritionists and clinical investigators concerned with interpretation of aberrant effects of therapeutic drugs.
Drugs and a methodological compendium : From bench to bedside
Provides a meticulous view on methodological drug discovery and development insights from bench to bedside. Focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. Covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
Drug repurposing : A new fashion for a new hope
The repurposing of drugs is becoming increasingly attractive as it avoids the long process and cost implications associated with bringing a novel drug to market i.e., drug repurposing is cost effective and time saving. This study will discuss the repositioning of several drugs that belong to different pharmaceutical classifications such as antimicrobials (itraconazole and fluoroquinolones), anti-diabetic agents (metformin and sodium glucose co-transporter 2 inhibitors), cardiovascular drugs (β-blockers and digoxin), anticonvulsants (topiramate), immunosuppressants (sirolimus), non-steroidal anti-inflammatory drugs (NSAIDs e.g., COX inhibitors), and cholesterol lowering drugs (statins).
Drug discovery targeting drug-resistant bacteria
Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included.
Drug delivery technology : Herbal bioenhancers in pharmaceuticals
Bioenhancers have been used in Ayurveda historically and are now being investigated for their pharmacological effi cacy. Herbal bioenhancers work on the gastrointestinal tract to improve absorption and drug bioavailability by acting on the drug metabolic process. Many herbal drugs show low activity due to their poor lipid solubility or improper molecular size. Piperine, gingerol, naringin, quercetin, niaziridin, glycyrrhizin, allicin, curcumin, genistein and others are able to enhance the bioavailability of active pharmaceuticals. This book details various facets of herbal bio-enhancers in a single comprehensive text.
Domain Decomposition Methods in Science and Engineering XVII
This volume contains a selection of papers presented at the 17th International Conference on Domain Decomposition Methods in Science and Engineering held at St. Wolfgang / Strobl, Austria, July 3 - 7, 2006. Domain decomposition is an active, interdisciplinary research area concerned with the development, analysis, and implementation of coupling and decoupling strategies in mathematical and computational models. Domain decomposition techniques provide efficient tools for treating problems in all Computational Sciences. The reader will become familiar with the newest domain decomposition technologies and their use for modeling and simulating of complex problems from different fields of applications.
Domain Decomposition Methods in Science and Engineering
Domain decomposition is an active, interdisciplinary research area that is devoted to the development, analysis and implementation of coupling and decoupling strategies in mathematics, computational science, engineering and industry.This book special focus has been on numerical analysis, computational issues,complex heterogeneous problems, industrial problems, and software development.
Do Smart Adaptive Systems Exist? : Best Practice for Selection and Combination of Intelligent Methods
This book is intended as a reference and a guide summarising and focusing on best practices when using intelligent techniques and building systems requiring a degree of adaptation and intelligence. Another attractive feature of the book is that it brings together experts from neural network, fuzzy, machine learning, evolutionary and hybrid systems communities who will provide their views on how these different intelligent technologies have contributed and will contribute to creation of smart adaptive systems of the future.
D-Modules, Perverse Sheaves, and Representation Theory
D-modules continues to be an active area of stimulating research in such mathematical areas as algebra, analysis, differential equations, and representation theory. Key to D-modules, Perverse Sheaves, and Representation Theory is the authors' essential algebraic-analytic approach to the theory, which connects D-modules to representation theory and other areas of mathematics. Significant concepts and topics that have emerged over the last few decades are presented, including a treatment of the theory of holonomic D-modules, perverse sheaves, the all-important Riemann-Hilbert correspondence, Hodge modules, and the solution to the Kazhdan-Lusztig conjecture using D-module theory.
Distributed Search by Constrained Agents : Algorithms, Performance, Communication
This book presents a comprehensive discussion on the field of distributed constraints, its algorithms and its active research areas. It introduces distributed constraint satisfaction and optimization problems and proceeds to present a complete state-of-the-art in DisCSP & DisCOP research.
Distributed Cooperative Laboratories : Networking, Instrumentation, and Measurements
This is a highly interdisciplinary topic, where various aspects converge: multimedia communications and networking, sensor networks, Grid technology, Quality of Service (QoS) provisioning and control, network management, measurement instrumentation and methodology, architecture of measurement systems. The material is organized into six parts: Technologies for Real-Time Interactive Multimedia Communications; Monitoring, Management and Configuration of Networks and Networking Devices; Data Acquisition and Aggregation in Sensor Networks; Grid Structures for Distributed Cooperative Laboratories; Architectures and Techniques for Tele-Measurements; Virtual Immersive Communications and Distance Learning. Each contribution presents a self-contained treatment, within a framework that provides the reader with an up-to-date picture of the most recent state-of-the-art developments.
Discrete Differential Geometry
Discrete differential geometry is an active mathematical terrain where differential geometry and discrete geometry meet and interact. It provides discrete equivalents of the geometric notions and methods of differential geometry, such as notions of curvature and integrability for polyhedral surfaces. Current progress in this field is to a large extent stimulated by its relevance for computer graphics and mathematical physics. This collection of essays, which documents the main lectures of the 2004 Oberwolfach Seminar on the topic, as well as a number of additional contributions by key participants, gives a lively, multi-facetted introduction to this emerging field.
DiPiro’s pharmacotherapy : A pathophysiologic approach
It is this in-depth knowledge of pharmacotherapy, combined with the clinical experience gained through postgraduate training in direct patient care practice, that allows the pharmacist to be the "medication therapy expert" on the healthcare team and to proactively address medication-related problems.It is provides knowledge necessary to prevent, identify, and manage disease and medication-related problems
Digital Image Processing
The book offers an integral view of image processing from image acquisition to the extraction of the data of interest. The discussion of the general concepts is supplemented with examples from applications on PC-based image processing systems and ready-to-use implementations of important algorithms. Each chapter now includes exercises that help you to test your understanding, train your skills, and introduce you to real-world image processing tasks. An important part of the exercises is a wealth of interactive computer exercises, which cover all topics of this textbook.
Digital Holography and Three-Dimensional Display : Principles and Applications
Digital (or electronic) holography and its application to 3-D display is one of the formidable problems of evolving areas of high technology that has been receiving great attention in recent years. The realization of life-size interactive 3-D displays has been a seemingly unobtainable goal. Technology is not quite at that level yet, but advances in 3-D display now allow us to take important steps toward the achievement of this objective. The reader is presented with the state-of-the-art developments in both digital holography and 3-D display techniques. The book contains a large amount of research material as well as reviews, new ideas and insights that will be useful for graduate students, scientists, and engineers working in the field.
Digital Holography : Digital Hologram Recording, Numerical Reconstruction, and Related Techniques
This book presents a self-contained treatment of the principles and major applications of digital hologram recording and numerical reconstruction (Digital Holography). The first part deals with optical foundations and the theory of holography. The next section describes how to record holograms directly with an electronic sensor (CCD) and describes the various reconstruction techniques. A special chapter is designated to digital holographic interferometry with applications in deformation and shape measurement and refractive index determination. Applications in imaging and microscopy are also described. The next part discusses special techniques such as digital light-in-flight holography, holographic endoscopy, information encrypting and comparative holography. In the last chapter related techniques of speckle metrology are treated briefly.
Diffuse matter from star forming regions to active galaxies : A volume honouring John Dyson
In this volume dedicated to him, introductory reviews to a number of the key processes and to the sources themselves are given by leading experts. The mechanisms in which the multi-component natures of media affect their dynamics receive particular attention, but the roles of hydromagnetic effects are also highlighted.
Developments in Fish Telemetry ; Proceedings of the Sixt Conference on Fish Telemetry held in Europe
This volume includes 33 peer-reviewed papers presented at the Sixth Conference on Fish Telemetry held in Europe (Sesimbra, Portugal, 5-11 June 2005). The papers focus on the application of aquatic telemetry techniques by scientists to investigate fundamental aspects of animal biology in order to conserve and manage natural resources. The topics addressed in this issue are human impacts and fisheries, migration and behaviour, species conservation and habitat rehabilitation, and methodology and new technology. This book is aimed at scientists and engineers actively involved in aquatic telemetry projects, aquatic biologists (marine and freshwater), fisheries biologist and managers.
Development of linguistic linked open data resources for collaborative data-Intensive research in the language sciences
This volume examines the challenges inherent in making diverse data in linguistics and the language sciences open, distributed, integrated, and accessible, thus fostering wide data sharing and collaboration. It is unique in integrating the perspectives of language researchers and technical LOD (linked open data) researchers. Reporting on both active research needs in the field of language acquisition and technical advances in the development of data interoperability, the book demonstrates the advantages of an international infrastructure for scholarship in the field of language sciences.
