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Contemporary Accounts in Drug Discovery and Development
Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners’ knowledge of chemistry and biology, but also—and perhaps more importantly—on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field.
Constructions of cancer in early Modern England : Ravenous natures
Cancer is perhaps the modern world's most feared disease. Yet, we know relatively little about this malady's history before the nineteenth century. This book provides the first in-depth examination of perceptions of cancerous disease in early modern England. Looking to drama, poetry and polemic as well as medical texts and personal accounts, it contends that early modern people possessed an understanding of cancer which remains recognizable to us today. Many of the ways in which medical practitioners and lay people imagined cancer – as a 'woman's disease' or a 'beast' inside the body – remain strikingly familiar, and they helped to make this disease a byword for treachery and cruelty in discussions of religion, culture and politics. Equally, cancer treatments were among the era's most radical medical and surgical procedures. From buttered frog ointments to agonizing and dangerous surgeries, they raised abiding questions about the nature of disease and the proper role of the medical practitioner.
Constructing Correct Software
Central to Formal Methods is the so-called Correctness Theorem which relates a specification to its correct Implementations. This theorem is the goal of traditional program testing and, more recently, of program verification (in which the theorem must be proved). Proofs are difficult, though even with the use of powerful theorem provers. This volume explains and illustrates an alternative method, which allows the construction of (necessarily correct) algorithms from a specification using algebraic transformations and refinement techniques which prevent the introduction of errors. Based on teaching material used extensively at Loughborough University, John Cooke introduces the basics, using simple examples and lots of detailed working (which can often be re-used). Constructing Correct Software will provide invaluable reading for students and practitioners of Computer Science and Software Engineering to whom correctness of software is of prime importance.
Constitutional law : principles and policies
Relied on by students, professors, and practitioners, Erwin Chemerinsky's popular treatise clearly states the law and identifies the underlying policy issues in each area of constitutional law. Thorough coverage of the topic makes it appropriate for both beginning and advanced courses.
Conscious in a Vegetative State? A Critique of the PVS Concept
This book traces the origins of prevailing perceptions about PVS and submits these to critical examination. In doing this it comes to the conclusion that inadequate attention has been paid to acknowledging what is not known about affected individuals and that assumptions have consistently come to be traded as facts. Re-examination of the basis of the PVS and the adoption of a more scientific approach is long overdue and is owed to the community at large which has generally been provided by many medical practitioners with a 'dumbed-down' account of the condition.
Computer-Aided Design of User Interfaces IV
Computer-Aided Design of User Interfaces IV gathers the latest research of experts, research teams and leading organisations involved in computer-aided design of user interactive applications supported by software, with specific attention for platform-independent user interfaces and context-sensitive or aware applications. This includes: innovative model-based and agent-based approaches, code-generators, model editors, task animators, translators, checkers, advice-giving systems and systems for graphical and multimodal user interfaces. It also addresses User Interface Description Languages. This books attempts to emphasize the software tool support for designing user interfaces and their underlying languages and methods, beyond traditional development environments offered by the market. It will be of interest to software development practitioners and researchers whose work involves human-computer interaction, design of user interfaces, frameworks for computer-aided design, formal and semi-formal methods, web services and multimedia systems, interactive applications, and graphical user and multi-user interfaces.
Computer Vision, Graphics and Image Processing ; 5th Indian Conference, ICVGIP 2006, Madurai, India, December 13-16, 2006, Proceedings
The Indian Conference on Computer Vision, Graphics and Image Processing (ICVGIP) is a forum bringing together researchers and practitioners in these related areas, coming from national and international academic institutes, from government research and development laboratories, and from industry. The proceedings of ICVGIP 2006, published in Springer's series Lecture Notes in Computer Science, comprise 85 papers that were selected for presentation from 284 papers, which were submitted from all over the world.
Computer vision for biomedical image applications
The purpose of this book is to submit the workshop, “Computer Vision for Biomedical Image Applications: Current Techniques and Future Trends” (CVBIA), is to examine the diverse applications of computer vision to biomedical image applications, considering both current methods and promising new trends. An additional goal is to provide the opportunity for direct interactions between (1) prominent senior researchers and young scientists, including students, postdoctoral associates and junior faculty; (2) local researchers and international leaders in biomedical image analysis; and (3) computer scientists and medical practitioners. Our CVBIA workshop had two novel characteristics: each contributed paper was authored primarily by a young scientist, and the workshop attracted an unusually large number of well-respected invited speakers (and their papers).
Computer Viruses and Malware
This book discusses both the technical and human factors involved in computer viruses, worms, and anti-virus software. It also looks at the application of malicious software to computer crime and information warfare. Computer Viruses and Malware is designed for a professional audience composed of researchers and practitioners in industry. This book is also suitable as a secondary text for advanced-level students in computer science.
Computer Network Security
As society becomes increasingly dependent on computers and computer networks, computer problems continue to rise in number. Yet despite the proliferation of expert remedies, a viable solution to these security issues remains elusive, and society continues to suffer at the hands of cyber vandalism and computer viruses. This comprehensive text outlines and discusses today’s most important issues and concerns in computer network and information safety and security, and promises to ignite debate and participation in the ongoing global security dialog Computer Network Security is foremost an educational tool that aims to explore computer network infrastructure and protocol design security flaws and discusses current security solutions and best practices. It explores the security threats and vulnerabilities in the current network infrastructure and protocols and outlines current efforts including: Access Control and Authorization, Cryptography, Firewalls and VPNs, Web Security and Content Filtering, among others. The text further discusses various security proposals This text is an invaluable instructional and research tool for courses in computer and information security. Students or practitioners in computer science, information science, technology studies, library sciences, and information management studies will find this text particularly useful for their purposes. In addition, it is a rich resource for those looking to gain an understanding of computer infrastructures and network security threats.
Computational science and its applications - ICCSA 2006 ; Vol. 3983 ; International Conference, Glasgow, UK, May 8-11, 2006, Proceedings, Part IV
This ?ve-volume set was compiled following the 2006 International Conference on Computational Science and its Applications, ICCSA 2006. It represents the outstanding collection of almost 664 refereed papers selected from over 2,450 submissions to ICCSA 2006. Computational science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry.
Computational science and its applications - ICCSA 2006 ; Vol. 3982 ; International Conference, Glasgow, UK, May 8-11, 2006, Proceedings, Part III
This ?ve-volume set was compiled following the 2006 International Conference on Computational Science and its Applications, ICCSA 2006. It represents the outstanding collection of almost 664 refereed papers selected from over 2,450 submissions to ICCSA 2006. Computational science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry.
Computational science and its applications - ICCSA 2006 ; Vol. 3981 ; International Conference, Glasgow, UK, May 8-11, 2006, Proceedings, Part II
This ?ve-volume set was compiled following the 2006 International Conference on Computational Science and its Applications, ICCSA 2006. It represents the outstanding collection of almost 664 refereed papers selected from over 2,450 submissions to ICCSA 2006. Computational science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry.
Computational science and its applications - ICCSA 2006 ; Vol. 3980 ; International Conference, Glasgow, UK, May 8-11, 2006, Proceedings, Part I
This ?ve-volume set was compiled following the 2006 International Conference on Computational Science and its Applications, ICCSA 2006. It represents the outstanding collection of almost 664 refereed papers selected from over 2,450 submissions to ICCSA 2006. Computational science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry.
Computational science and its applications - ICCSA 2006 ;Vol. 3984 ; International Conference, Glasgow, UK, May 8-11, 2006, Proceedings, Part V
This ?ve-volume set was compiled following the 2006 International Conference on Computational Science and its Applications, ICCSA 2006. It represents the outstanding collection of almost 664 refereed papers selected from over 2,450 submissions to ICCSA 2006. Computational science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry.
Computational science and its applications - ICCSA 2005 ; Vol. 3483 ; International Conference, Singapore, May 9-12, 2005, Proceedings, Part IV
The four volume set assembled following The 2005 International Conference on Computational Science and its Applications, ICCSA 2005, held in Suntec International Convention and Exhibition Centre, Singapore, from 9 May 2005 till 12 May 2005, represents the ?ne collection of 540 refereed papers selected from nearly 2,700 submissions. Computational Science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry. Due to the shear size of many challenges in computational science, the use of supercomputing, parallel processing, and - phisticated algorithms is inevitable and becomes a part of fundamental t- oretical research as well as endeavors in emerging ?elds.
Computational science and its applications - ICCSA 2005 ; Vol. 3482 ; International Conference, Singapore, May 9-12. 2005, Proceedings, Part III
The four volume set assembled following The 2005 International Conference on Computational Science and its Applications, ICCSA 2005, held in Suntec International Convention and Exhibition Centre, Singapore, from 9 May 2005 till 12 May 2005, represents the ?ne collection of 540 refereed papers selected from nearly 2,700 submissions. Computational Science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry. Due to the shear size of many challenges in computational science, the use of supercomputing, parallel processing, and - phisticated algorithms is inevitable and becomes a part of fundamental t- oretical research as well as endeavors in emerging ?elds.
Computational science and its applications - ICCSA 2005 ; International Conference, Singapore, May 9-12, 2005, Proceedings, Part II
The four volume set assembled following The 2005 International Conference on Computational Science and its Applications, ICCSA 2005, held in Suntec International Convention and Exhibition Centre, Singapore, from 9 May 2005 till 12 May 2005, represents the ?ne collection of 540 refereed papers selected from nearly 2,700 submissions. Computational Science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry. Due to the shear size of many challenges in computational science, the use of supercomputing, parallel processing, and - phisticated algorithms is inevitable and becomes a part of fundamental t- oretical research as well as endeavors in emerging ?elds.
Computational Methods in Financial Engineering : Essays in Honour of Manfred Gilli
The focus of this book is the development of computational methods and analytical models in financial engineering that rely on computation. The book contains eighteen chapters written by leading researchers in the area on portfolio optimization and option pricing; estimation and classification; banking; risk and macroeconomic modelling. It explores and brings together current research tools and will be of interest to researchers, analysts and practitioners in policy and investment decisions in economics and finance. "This book collects frontier work by researchers in computational economics in a tribute to Manfred Gilli, a leading member of this community. Contributions cover many of the topics researched by Gilli during his career: portfolio optimization and option pricing, estimation and classification, as well as banking, risk and macroeconomic modeling. The editors have put together a remarkable panorama of the rapidly growing and diversifying field of computational economics and finance
Computational intelligence and bioinformatics ; International conference on intelligent computing, ICIC 2006, Kunming, China, August 16-19, 2006, Proceedings, Part III
The International Conference on Intelligent Computing (ICIC) was formed to provide an annual forum dedicated to the emerging and challenging topics in artificial intelligence, machine learning, bioinformatics, and computational biology, etc. It aims to bring together researchers and practitioners from both academia and industry to share ideas, problems and solutions related to the multifaceted aspects of intelligent computing.the theme for this conference was “Emerging Intelligent Computing Technology and Applications”. Papers related to this theme were especially solicited, including theories, methodologies, and applications in science and technology.
