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Homocysteine
Homocysteine is a non-proteinogenic α-amino acid. It is a homologue of the amino acid cysteine, differing by an additional methylene bridge (-CH2-). It is biosynthesized from methionine by the removal of its terminal methyl group. In the body, Homocysteine (HCY) can be recycled into methionine or converted into cysteine with the aid of certain B-vitamins. A high level of Homocysteine in the blood (hyperhomocysteinemia) makes a person more prone to endothelial cell injury, which leads to inflammation in the blood vessels, which in turn may lead to atherogenesis, which can result in ischemic injury. Therefore, hyperhomocysteinemia is a possible risk factor for coronary artery disease (CAD). Coronary artery disease occurs when an atherosclerotic plaque blocks blood flow to the coronary arteries, which supply the heart with oxygenated blood.
High Tc superconductors and related transition metal oxides : Special Contributions in Honor of K. Alex Müller on the Occasion of his 80th Birthday
This book containing 30 articles the contributions reflect the major research areas of K. Alex Müller which he activated in high temperature superconductivity and phase transitions. They are theoretical as well as experimental ones and focus mainly on high temperature superconductivity. A smaller part deals with ferroelectricity and their applications.
High Power Diode Lasers : Technology and Applications
In a very comprehensive way this book covers all aspects of high power diode laser technology for materials processing. Basics as well as new application oriented results obtained in a government funded national German research project are described in detail.
High Performance Tensegrity-Inspired Metamaterials and Structures
New metamaterials, smart materials and structures, and adaptive systems with adjustable behaviour or which use high performance or 'extremal' materials can be applied to bigger structural systems, such as cellular tensegrity lattices with extremal mechanical properties. Numerical analyses justify tensegrities and discrete and continuum models offer two main approaches to the analysis of tensegrity-based mechanical metamaterials and lattices. Two examples of 2D and 3D tensegrity modules and lattices, and potential applications in civil engineering are presented.
High Energy Density Materials
The series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table. It focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves.
High Dielectric Constant Materials : VLSI MOSFET Applications
Issues relating to the high-K gate dielectric are among the greatest challenges for the evolving International Technology Roadmap for Semiconductors (ITRS). More than just an historical overview, this book will assess previous and present approaches related to scaling the gate dielectric and their impact, along with the creative directions and forthcoming challenges that will define the future of gate dielectric scaling technology. Topics include: an extensive review of Moore's Law, the classical regime for SiO2 gate dielectrics; the transition to silicon oxynitride gate dielectrics; the transition to high-K gate dielectrics (including the drive towards equivalent oxide thickness in the single-digit nanometer regime); and future directions and issues for ultimate technology generation scaling. The vision, wisdom, and experience of the team of authors will make this book a timely, relevant, and interesting, resource focusing on fundamentals of the 45 nm Technology Generation and beyond.
High Density Lipoproteins : From Biological Understanding to Clinical Exploitation
In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation.
Heterologous protein production in CHO cells : Methods and protocols
Explores the use of Chinese hamster ovary (CHO) cells in the production of therapeutic protein products. Beyond updates on earlier methodologies, the book also delves into the genetic manipulation of CHO cells for recombinant protein production, analysis of CHO cells using proteomic and metabolomic approaches, as well as methods for the characterization of recombinant protein products, such as glycosylation and host cell protein analysis.
Heterogeneous Enantioselective Hydrogenation : Theory and Practice
The book looks at the first relatively ineffective catalysts right through to modern highly effective enantioselective catalytic systems, comparable in their efficiency to chiral metal complexes and enzymatic systems. The book begins with a summary of the first work on heterogeneous metal catalysts, which showed only the principal possibilities of enantioselective reactions. The book then elaborates on metal catalysts which have enantioselectivities close to 100%. Finally, the book describes the practical utilization of chiral catalytic systems in processes of hydrogenation. The a - and b -hydroxy carboxylic acid esters produced are precursors for manufacturing many synthones used for medicines as well as for monomers used for biodegradable polyesters, both of which have important practical applications. The book summarizes more than 800 scientific papers in the field of enantioselective catalytic hydrogenation reactions, mainly those using heterogeneous metal catalysts. It provides detailed explanations of special techniques for the preparation of effective dissymmetric catalysts which provide highly efficient catalytic systems.
Heterocyclic Supramolecules I
Contributing to this book of six chapters were 14 scientists working in the field of supramolecular chemistry, with a special focus on molecular recognition, functional materials, and nanocarbon science. … Overall, this book is an informative summary on the progress that researchers have made over the past decade toward generating useful functional materials from heterocyclic supramolecules. This is an advanced text that should be most useful to those with an established background in supramolecular sciences and engineering.
Heterocyclic Antitumor Antibiotics
Heterocyclic Compounds Includes aspects such as synthesis, reaction mechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical studies, pharmacological aspects, applications in material sciences etc. Metabolism will be also included which will provide information useful in designing pharmacologically active agents. Pathways involving destruction of heterocyclic ring will also be dealt with so that synthesis of specifically functionalized non-heterocyclic molecules can be designed. Overall scope is to cover topics dealing with most of the areas of current trends in heterocyclic chemistry which will suit to a larger heterocyclic community.
Heterocycles from Transition Metal Catalysis : Formation and Functionalization
The book provides a representative selection of transition metal catalysed reactions, transformations that are relevant in heterocyclic chemistry. In this way, the authors provide a useful resource for members of the academic community looking for a textbook as well as industrial chemists in search of a reference book. This book is an invaluable resource for synthetic chemists, medicinal chemists, and those more generally interested in applied catalysis.
Hebrew Scholasticism in the Fifteenth Century : A History and Source Book
This book aims to respond to this need. After a historical introduction, where a "state of the art" about research on the relationship between Jewish philosophy and science and Latin Scholasticism in the thirtheenth-fifteenth centuries is given, the book consists of four chapters. Each of them offers a general bio-bibliographical survey of one or two key-authors of fifteenth-century "Hebrew Scholasticism", followed by English translations of some of their most significant "Scholastic" works or of some parts of them: Abraham Bibago’s "Treatise on the Plurality of Forms", Baruch Ibn Ya’ish’s commentaries on Aristotle’s "Nicomachean Ethics" and "De anima", Eli Habillo’s introduction to Antonius Andreas’s commentary on the "Metaphysics", Judah Messer Leon’s commentary on Aristotle’s "Physics" and questions on Porphyry’s "Isagoge".
Head and Neck Cancer Imaging ; 1st ed.
This book provides a comprehensive review of state-of-the-art imaging in head and neck cancer. Precise determination of tumor extent is of the utmost importance in these neoplasms, as it has important consequences for staging of disease, prediction of outcome and choice of treatment. Only the radiologist can fully appreciate submucosal, perineural, and perivascular tumor spread and detect metastatic disease at an early stage. Imaging is also of considerable benefit for patient surveillance after treatment.
Haploids in Crop Improvement II
This volume provides an excellent overview of haploid induction and the application of doubled haploids. The authors emphasize advances made in the understanding of microspore embryogenesis, but treat also advances in gynogenesis and the manipulation of parthenogenetic haploid development. The text contains a thorough discussion of the application of haploidy to the improvement of a number of species from various families.
Handbook of Practical X-Ray Fluorescence Analysis
X-Ray Fluorescence analysis (XRF) is a reliable multi-elemental and nondestructive analytical method widely used in research and industrial applications. This practical handbook provides self-contained modules featuring XRF instrumentation, quantification methods, and most of the current applications. The book gives a survey of the theoretical fundamentals, analytical instrumentation, software for data processing, various excitation regimes including gracing incidents and microfocus measurements, quantitative analysis, applications in routine and micro analysis, mineralogy, biology, medicine, criminal investigations, archeology, metallurgy, abrasion, microelectronics, environmental air and water analysis. It gives the basic knowledge on this technique, information on analytical equipment and guides the reader to the various applications.
Handbook of Pathogens and Diseases in Cephalopods
The aim of this book is to facilitate the identification and description of the different organs as well as pathogens and diseases affecting the most representative species of cephalopods focussed on Sepia officinalis, Loligo vulgaris and Octopus vulgaris. These species are valuable ‘morphotype’ models and belong to the taxonomic groups Sepioidea, Myopsida and Octopoda, which include most of the species with a high market value and aquaculture potential. The study is based on photographs at macroscopic and histological level in order to illustrate the role of the most important pathogens and related diseases from the view of a pathological diagnosis. The reader is able to familiarize with functional anatomy, necropsy and general histology of adults and paralarvae, as well as with the identification of different pathogens and pathologies. This work is thus an invaluable guide for the diagnosis of cephalopod diseases. Besides including pathogens for non-European cephalopod species, it also provides a useful contribution encouraging marine pathologists, parasitologists, veterinarians and those involved in fishery sanitary assessments, aquarium maintenance and aquaculture practices aiming to increase their knowledge about the pathology of cephalopods.
Handbook of nutrition and ophthalmology
The Handbook of Nutrition in Ophthalmology is the first general text on nutrition and eye health created for physicians, nutritionists, and researchers. Dr. Richard D. Semba provides important links between the epidemic of obesity and implications it has for eye disease and blindness. The volume addresses three broad themes throughout. The first is that a healthy diet as a major lifelong habit will likely have an impact on reducing a substantial portion of visual impairment and blindness. The second is that a historical perspective is essential to understanding current challenges in ophthalmology, medicine, and public health. The third theme is that many nutrients play a role in oxidative stress and inflammation, and this theory has emerged as a major underlying hypothesis in the pathogenesis of eye diseases.
Handbook of neurochemistry and molecular neurobiology : Neural Protein Metabolism and Function
This volume discusses aspects of neural protein metabolism. Although this subject is clearly very important and has numerous functional aspects, it did not always get the attention it clearly deserves. Perhaps there are many explanations for researchers hesitating in the past to focus on protein metabolism.
Handbook of neurochemistry and molecular neurobiology : Development and Aging Changes in the Nervous System
In the animal nervous system, a very high metabolic turnover, fragile but steep ionic gradients, and morphological and structural constraints - dictated by the necessity for prompt neuronal transmission of electrical impulses and necessary plasticity - result in a highly fragile organ system. Here, we address a small sampling of major constituents of neural function at the cellular and molecular level that play important roles in development and aging, two endogenous processes that embody features of allostasis or the dynamic shifts in set points for specific homeostatic mechanisms associated with development and aging. These chapters stress the dynamic features of neuronal responses to internal (developmental) cues or the more harmful external events (injury and disease) in a modern perspective.
