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Filgrastim in clinical oncology : Guarding against neutropenia
Granulocyte colony-stimulating factor (G-CSF) has driven the attention of researchers as a therapeutic agent for curing patients suffering from neutropenia. Despite the successful use of G-CSF, it currently requires daily injections, which are inconvenient, expensive, and distressing for children. Therefore, an alternative strategy for using G-CSF for treatment is needed. Understanding the G-CSF structure, expression, mechanism of action, and how it induces neutrophils mobilization is crucial to producing promising cancer therapy. The ability of G-CSF to mobilize hematopoietic stem cells from the bone marrow into the blood circulation was consequently exploited and altered the practice of hematopoietic stem cell transplantation.
Fibrogenesis : Cellular and molecular basis
Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibrotic diseases. Knowledge on molecular and celluar basis of fibrotic diseases has provided opportunities to develop selective and effective gene-based therapeutic options.
Female Employment and Gender Gaps in China
This book investigates female employment and the gender gap in the labor market and households during China’s economic transition period. It provides the reader with academic evidence for understanding the mechanism of female labor force participation, the determinants of the gender gap in the labor market, and the impact of policy transformation on women’s wages and employment in China from an economics perspective
Feldman and Pike's vitamin D; Vol. 1 : Biochemistry, physiology and diagnostics
Presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic insights into the mechanisms of disease.
Fatigue Science for Human Health
Fatigue is quite a familiar sensation, one that everyone is likely to have experienced. Its molecular and neural mechanisms have not yet been elucidated, however, probably because of the complicated nature of its causes. To provide a broad forum for discussion, the International Conference on Fatigue Science was organized, the first being held in 2002 in Sandhamn, Sweden, and the second in 2005 in Karuizawa, Japan. Subsequently it was decided that the papers presented at the two conferences should be collected and incorporated in this pioneering work, Fatigue Science for Human Health. The book summarizes fatigue researchers' achievements, explains the status of the research on fatigue, and presents perspectives on remedies for chronic fatigue and chronic fatigue syndrome. The result is an authoritative guide to recent progress in the molecular and neural mechanisms of fatigue and in the development of the ways to prevent and overcome fatigue and chronic fatigue.
Fast Reactions in Energetic Materials : High-Temperature Decomposition of Rocket Propellants and Explosives
Modern energetic materials include explosives, blasting powders, pyrotechnic m- tures and rocket propellants [1, 2]. The study of high-temperature decomposition of condensed phases of propellants and their components (liquid, solid and hybrid) is currently of special importance for the development of space-system engineering [3, 4]. To better understand the burning mechanisms (stationary, nonstationary, - steady) of composite solid propellants and their components, information about the macrokinetics of their high-temperature decomposition is required [5]. To be able to evaluate the ignition parameters and conditions of safe handling of heat-affected explosives, one needs to know the kinetic constants of their high-temperature - composition. The development of new composite solid propellants characterized by high performance characteristics (high burning rates, high thermal stability, stability to intrachamber perturbations, and other aspects) is not possible without quanti- tive data on the high-temperature decomposition of composite solid propellants and their components [6].
Fas Signaling
Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule.
Extreme Ocean Waves
The book details the vast progress that has been achieved in the understanding of the physical mechanisms of rogue wave phenomenon in recent years. The selected articles address such issues as the formation of freak waves due to modulation instability of nonlinear wave field, physical and statistical properties of rogue wave generation in deep water and in shallow water, various models of nonlinear water waves, special analysis of nonlinear resonances between water waves and the relation between observations and freak wave theories.
Extinction governance, finance and accounting : Implementing a species protection action plan for the financial markets
The book presents plans, metrics, frameworks, mechanisms and financial innovations that can be, and are being, implemented through the financial markets in order to save and protect species, enhance biodiversity and, at the same time, preserve the financial markets and the business world.
Exploring Resilience : A Scientific Journey from Practice to Theory
Resilience has become an important topic on the safety research agenda and in organizational practice. Most empirical work on resilience has been descriptive, identifying characteristics of work and organizing activity which allow organizations to cope with unexpected situations. Fewer studies have developed testable models and theories that can be used to support interventions aiming to increase resilience and improve safety. In addition, the absent integration of different system levels from individuals, teams, organizations, regulatory bodies, and policy level in theory and practice imply that mechanisms through which resilience is linked across complex systems are not yet well understood. Scientific efforts have been made to develop constructs and models that present relationships; however, these cannot be characterized as sufficient for theory building. There is a need for taking a broader look at resilience practices as a foundation for developing a theoretical framework that can help improve safety in complex systems.
Exoplanets : Detection, Formation, Properties, Habitability
This edited, multi-author volume will be an invaluable introduction and reference to all key aspects in the field of exoplanet research. The reviews cover: Detection methods and properties of known exoplanets, Detection of extrasolar planets by gravitational microlensing. The formation and evolution of terrestrial planets in protoplanetary and debris disks. The brown dwarf-exoplanet connection. Formation, migration mechanisms and properties of hot Jupiters. Dynamics of multiple exoplanet systems. Doppler exoplanet surveys. Searching for exoplanets in the stellar graveyard. Formation and habitability of extra solar planets in multiple star systems. Exoplanet habitats and the possibilities for life. Moons of exoplanets: habitats for life.
Exogenous and endogenous factors affecting happiness, happy mind, happy life
Emotions are the language of the soul. Our brain is the emotional center where every emotion is produced including happiness. Happiness underlying factors are considerable from two dimensions: endogenous factors and exogenous factors Therefore, this research aimed to consider biological factors that underlie happiness. The research is divided into several sub-groups (brain, genetics, neurotransmitters, endocrinology, hormones, drugs, diseases, and other exogenous factors). In spite of difficulties in finding special genes, several genes distributed to emotion and mood. Neuroscience studies showed that some part of brain (e.g. amygdala, hipocamp and limbic system) and neurotransmitters (e.g. dopamine, serotonin, norepinefrine and endorphin) play a role in control of happiness. A few studies pointed to the role of cortisol and adrenaline (adrenal gland) and oxitocin (pituitary gland) in controlling happiness.
Evolving methods for macromolecular crystallography : The structural path to the understanding of the mechanism of action of CBRN agents
This volume comprises papers presented at the 2005 edition of the “Crystallography of Molecular Biology” courses that have been held since 1976 at the Ettore Majorana Centre for Scientific Culture in Erice, Italy. The papers span the breadth of material presented in the course, which emphasized the practical aspects of modern macromolecular crystallography and its applications.
Evolvable systems : From biology to hardware ; 6th International Conference, ICES 2005, Sitges, Spain, September 12-14, 2005, Proceedings
The flying machines proposed by Leonardo da Vinci in the fifteenth century, the se- reproducing automata theory proposed by John von Neumann in the middle of the twentieth century and the current possibility of designing electronic and mechanical systems using evolutionary principles are all examples of the efforts made by humans to explore the mechanisms present in biological systems that permit them to tackle complex tasks. These initiatives have recently given rise to the emergent field of b- inspired systems and evolvable hardware. The inaugural workshop, Towards Evolvable Hardware, took place in Lausanne in October 1995, followed by the successive events of the International Conference on Evolvable Systems: From Biology to Hardware, held in Tsukuba (Japan) in October 1996, in Lausanne (Switzerland) in September 1998, in Edinburgh (UK) in April 2000, in Tokyo (Japan) in October 2001, and in Trondheim (Norway) in March 2003. Following the success of these past events the sixth international conference was aimed at presenting the latest developments in the field, bringing together researchers who use biologically inspired concepts to implement real systems in artificial intelligence, artificial life, robotics, VLSI design, and related domains. The sixth conference consolidated this biennial event as a reference meeting for the community involved in bio-inspired systems research. All the papers received were reviewed by at least three independent reviewers, thus guaranteeing a high-quality bundle for ICES 2005.
Evolutionary Intelligence : An introduction to theory and applications with Matlab
This book gives a good introduction to evolutionary computation for those who are first entering the field and are looking for insight into the underlying mechanisms behind them. Emphasizing the scientific and machine learning applications of genetic algorithms instead of applications to optimization and engineering, the book could serve well in an actual course on adaptive algorithms.
Evolution, Monitoring and Predicting Models of Rockburst : Precursor Information for Rock Failure
Focuses on investigating predicting precursor information and key points of rockburst in mining engineering through laboratory experiment, theoretical analysis, numerical simulation and case studies. Understanding the evolution patterns for the microstructure instability of rock is a prerequisite for rockburst prediction. The book provides a guide for readers seeking to understand the evolution patterns for the microstrucure of rock failure, the predicting key point of rock failure and the rockburst predicting model. It will be an essential reference to understand mechanism of rockburst and sheds new light on dynamic disasters prediction. Chapters are carefully developed to cover (1) The evolution patterns for the microstructure instability of rock; (2) Rockburst hazard monitoring and predicting criterion and predicting models. The book addresses the issue with a holistic and systematic approach that investigates the occurrence mechanism of rockburst based on the evolution patterns for the microstructure of rock failure and establishes the predicting model of rockburst.
Event-Based Programming : Taking Events to the Limit
This book teaches you how to develop software based on parts that interact primarily through an event mechanism. You'll learn how to use events in many different situations, to solve recurring development problems without coupling. The book introduces Signal Wiring Diagram, a novel form of software diagram similar to the circuit diagrams used by hardware designers. The book concludes with a series of case studies, incorporating all featured concepts.
Evaluation of the use of medicine plants in cancer treatment
Turmeric (Curcuma longa) and ginger (Zingiber officinale) have been widely studied for their potential anticancer effects, primarily due to the bioactive compounds curcumin and gingerol. Both compounds exhibit significant therapeutic properties, including anti-inflammatory, antioxidant, pro-apoptotic, and anti-angiogenic activities, which target key pathways implicated in cancer progression, such as NF-κB, STAT-3, and mTOR. Through these mechanisms, curcumin and gingerol inhibit tumor growth, reduce metastasis, and enhance the efficacy of conventional cancer treatments.
Evaluating evidence of mechanisms in medicine : Principles and procedures
This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness.
Eutrophication of Shallow Lakes with Special Reference to Lake Taihu, China
Eutrophication and algal blooms are worldwide environmental issues in lakes. The eutrophication process and formation mechanisms of algal blooms are particularly complicated in shallow lakes due to the strong lake–land, air–water and water–sediment interactions. This volume features papers presented at the International Symposium on the Eutrophication Process and Control in Large Shallow Lakes – with Special Reference to Lake Taihu, a Shallow Subtropical Chinese Lake, held in Nanjing, China, 22–26 April, 2005. The topics include: physical processes and their effects on shallow lake ecosystems; biogeochemistry of sediments and nutrient cycling in shallow lakes; algal blooms and ecosystem response in shallow lakes; eutrophication control and restoration in shallow lakes; and resource exploitation, environmental protection and sustainable management in shallow lakes.
