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Hypocretins : Integrators of Physiological Signals
The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression.
Hydrogenosomes and Mitosomes : Mitochondria of Anaerobic Eukaryotes
"Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes" provides a summary of the current knowledge of these organelles, which occur in unicellular, often parasitic organisms, including human pathogens. The distribution of these organelles is broad, but they were detected primarily in an anoxic habitat or nutrient rich intracellular niche that permits life without the efficient energy generating system of typical mitochondria. Their common characteristic is that they lack the aerobic energy conservation system of typical mitochondria and that they are usually the site of the synthesis of iron-sulfur clusters, regarded as the only indispensable function of eukaryotic mitochondria.These mitochondria-related organelles exhibit a variety of structures and functions. This work describes properties such as protein import, structure, metabolism, adaptation, proteome and their role in drug activation and resistance. Further topics include the evolution and biogenesis of these organelles.
Hydrogen Materials Science and Chemistry of Carbon Nanomaterials
The 2005 International Conference “Hydrogen Materials Science and Chemistry of Carbon Nanomaterials” (ICHMS’2005) was held in September 5-11, 2005 in the remarkable city Sevastopol (Crimea, Ukraine) known for its heroic and unusual th fate. In the tradition of the earlier ICHMS conferences, this 9 ICHMS’2005 meeting served as an multidisciplinary forum for the presentation and discussion of the most recent research on transition to hydrogen-based energy systems, technologies for hydrogen production, storage, utilization, materials processing and chemical behavior, energy and environmental problems. The aim of ICHMS’2005 was to provide the wide overview of the latest scientific results on basic research and technological applications of hydrogen interactions with metals and other materials.
Hydroboration and Organic Synthesis : 9-Borabicyclo [3.3.1] nonane (9-BBN)
Borabicyclo [3.3.1]nonane, a commercially available reagent, is the most versatile hydroborating reagent to synthesize organoboranes (B-R-9-BBN). The reagent exhibits remarkable regio-, chemo-, and stereoselectivity during hydroboration reactions. The organoboranes can be converted to C-H, C-O, C-N, C-S, C-halogen, C-metal and above all C-C bonds. In addition, the suitable substituted / unsaturated R of B-R-9-BBN can be utilized to produce dienes, enynes, allenes etc. with defined stereochemistry. 9-BBN’s derivatives have been elegantly used for the asymmetric reduction of ketone moiety. Diels-Alder and Suzuki reactions have expanded the utility of 9-BBN for the synthesis of a variety of organic compounds required for industry. Consequently, this vast field in the form of a book will be helpful to synthetic organic chemists for easy access to literature, required for chemical transformations.
Hybrid metaheuristics ; Vol. 4030 ; 3rd International Workshop, HM 2006, Gran Canaria, Spain, October 13-14, 2006, Proceedings
The selection of papers for HM 2006 consolidated some of the mainstream issues that have emerged from the past editions. Firstly, there are prominent examples of e?ective hybrid techniques whose design and implementation were motivated by challenging real-world applications. We believe this is particularly important for two reasons: on the one hand, researchers are conscious that the primary goal of developing algorithms is to solve relevant real-life problems; on the other hand, the path towarde?cient solving methods for practical problems is a source of new outstanding ideas and theories. A second important issue is that the research community on metaheur- tics has become increasingly interested in and open to techniques and methods known from arti?cial intelligence (AI) and operations research (OR). So far, the most representative examples of such integration have been the use of AI/OR techniques as subordinates of metaheuristic methods. As a historical and - ymological note, this is in perfect accordance with the original meaning of a metaheuristic as a “general strategy controlling a subordinate heuristic. ” The awareness of the need for a sound experimental methodology is a third keypoint.
Hybrid metaheuristics ; Vol. 3636 ; 2nd International Workshop, HM 2005, Barcelona, Spain, August 29-30, 2005. Proceedings
Constitutes the refereed proceedings of the Second International Workshop on Hybrid Metaheuristics, HM 2005, held in Barcelona, Spain, in August 2005. In this book, the papers addresses topics such as: low-level hybridization, high-level hybridization, portfolio techniques, expert systems, co-operative search, taxonomy, terminology, and more.
Hybrid metaheuristics ; 5th International Workshop, HM 2008, Málaga, Spain, October 8-9, 2008. Proceedings
This book constitutes the refereed proceedings of the 5th International Workshop on Hybrid Metaheuristics, HM 2008, held in Malaga, Spain, in October 2008.The 14 revised full papers presented were carefully reviewed and selected from 33 submissions. The papers discuss specific aspects of combinations of metaheuristics and other solving techniques for tackling particular relevant constrained optimization problems, such as fiber optic networks, time tabling and freight train scheduling problems.
Hybrid metaheuristics ; 4th International Workshop,HM 2007, Dortmund, Germany, October 8-9, 2007, Proceedings
This book constitutes the refereed proceedings of the 4th International Workshop on Hybrid Metaheuristics, HM 2007, held in Dortmund, Germany. The 14 revised full papers discuss specific aspects of hybridization of metaheuristics, hybrid metaheuristics design, development and testing.
Hybrid metaheuristics : An emerging approach to optimization
The book is intended both to provide an overview of hybrid metaheuristics to novices of the field, and to provide researchers from the field with a collection of some of the most interesting recent developments.
Humanizing modern medicine : An introductory philosophy of medicine
In this book the author explores the shifting philosophical boundaries of modern medical knowledge and practice occasioned by the crisis of quality-of-care, especially in terms of the various humanistic adjustments to the biomedical model. To that end he examines the metaphysical, epistemological, and ethical boundaries of these medical models. He begins with their metaphysics, analyzing the metaphysical positions and presuppositions and ontological commitments upon which medical knowledge and practice is founded. Next, he considers the epistemological issues that face these medical models, particularly those driven by methodological procedures undertaken by epistemic agents to constitute medical knowledge and practice.
Human motion : Understanding, modeling, capture and animation
Edward Muybridge (1830–1904) is known as the pioneer in motion capt- ing with his famous experiments in 1887 called “Animal Locomotion”. Since then, the feld of animal or human motion analysis has grown in many dir- tions. However, research and results that involve human-like animation and the recovery of motion is still far from being satisfactory. Progress in human motion analysis depends on empirically anchored and grounded research in computer vision, computer graphics, and biomechanics. This book is based on a June 2006 workshop held in Dagstuhl, Germany. This workshop brought together for the frst time researchers from the afo- mentioned disciplines.
Human microbiome : Clinical implications and therapeutic interventions
The human microbiome refers to the complete microorganisms inhabiting the human body sites including skin, ear, nose, oral cavity, the genital, gastrointestinal and respiratory tracts, and body fluids such as breast milk, saliva, and urine. It is a significant and essential organ recognized for the body and has an established involvement in the host wellbeing, in terms of nutritional requirements and immunomodulation. Talks about how alteration and imbalance in the same can have clinical implications associated with a multitude of gastrointestinal, lifestyle-associated, and neurodegenerative disorders. How the proliferation of specific groups of bacteria and their metabolic activities, as a result of intestinal dysbiosis leads to the 'leaky gut' condition thereby influences brain activity via the bidirectional gut-brain axis. It also coves the importance of microbial seeding and how it can be influenced by the mode of delivery, nutrition, and medication. This book also provides various therapeutic interventions such as the establishment of stool banks and Faecal microbiota transplantation (FMT) that have recently proved promising in the treatment of ASD, Inflammatory Bowel Disease, and Ulcerative Colitis. This book provides a deeper understanding of the development of the human gut microbiome and the factors driving its dysbiosis. This book is a valuable read for health professionals, medical students, nutritionists, and scientific research communities who are eager to update themselves with recent trends in microbiome research. It will also aid gastroenterologists and nutritionists to make well-informed choices regarding therapeutic regimes.
Human Drug Metabolism
The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact.
How Ficta Follow Fiction : A Syncretistic Account of Fictional Entities
This book presents a novel theory of fictional entities which is syncretistic insofar as it integrates the work of previous authors. It puts forward a new metaphysical conception of the nature of these entities, according to which a fictional entity is a compound entity built up from both a make-believe theoretical element and a set theoretical element. The fictional entity is constructed by imagining the existence of an individual with certain properties and adding a set-theoretical element consisting of the set of properties corresponding to the properties of the imagined entity.
Hot cracking phenomena in welds II
This is the second in a series of compendiums devoted to weld hot cracking phenomena, where this subject has been further scrutinized, bringing to bare the most current thoughts on this complex and diverse subject. With 22 technical papers in total, this book is divided in such a way that specific classifications of hot cracks are examined in detail, including solidification, liquation, and ductility dip cracking. The first chapter looks at solidification cracking theory, applying the most modern approaches to modelling weld solidification. Also provided here is a comprehensive review of cracking models. This is followed by two chapters characterizing solidification cracking behaviour for specific alloy systems: ferrous plus nickel-based alloys and aluminium alloys, respectively. The fourth chapter considers liquation cracking in ferrous alloys, and the fifth examines ductility-dip cracking.
Hot cracking phenomena in welds
The first chapter provides an overview of the various hot cracking phenomena. Different mechanisms of solidification cracking proposed in the past decades are summarized and new insight is particularly given into the mechanism of ductility dip cracking. The effects of different alloying elements on the hot cracking resistance of various materials are shown in the second chapter and, as a special metallurgical effect, the initiation of stress corrosion cracking at hot cracks has been highlighted. The third chapter outlines how numerical analyses and other modelling techniques can be utilized to describe hot cracking phenomena and how such results might contribute to the explanation of the mechanisms. Various hot cracking test procedures are presented in the final chapter with a special emphasis on standardization. For the engineering and natural scientists in research and development the book provides both, new insight and a comprehensive overview of hot cracking phenomena in welds. The contributions additionally give numerous individual solutions and helpful advice for international welding engineers to avoid hot cracking in practice. Furthermore, it represents a very helpful tool for upper level metallurgical and mechanical engineering students.
Hormones, metabolism and the benefits of exercise
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
Hormone balance for dummies
Hormones are your body's chemical "messengers," the regulators of essential functions like metabolism, reproduction, mood, and growth. But, in our 24/7, hyper-connected modern world, many of us increasingly find ourselves in situations of chronic stress that can imbalance or disrupt our bodies' natural hormonal balance. In Hormone Balance For Dummies, renowned hormone health coach Isabella Mainwaring delivers an accessible and exciting new take on hormonal imbalance. You'll discover why hormone balance is so important for you and contributes to everything from the maintenance of a healthy weight to fertility, mental wellness, and overall health. The author goes beyond diet and lifestyle to offer practical nervous system regulation tips and dive deep on available treatment options for hormonal imbalance
Hormonal Carcinogenesis IV
Uniquely, Hormonal Carcinogenesis IV, integrates salient aspects of hormone-related cancers of interest to epidemiologists, basic researchers, and clinicians. The most recent advances in the major hormone-related cancers are presented by leaders of their specialty. The chapters in this volume deal with the causation, dependence, and resistance of endocrine-related cancers with particular emphasis on the most common neoplasms occuring in men and woman world wide, such as breast, prostate, uterine, and ovarian cancers.
Homocysteine : Related Vitamins and Neuropsychiatric Disorders
There is an increasing interest in the connection between the homocysteine metabolism and neuropsychiatric disease with a steeply increasing number of publications. In particular, the association between homocysteine metabolism and cognitive decline/dementia attracts much interest. If simple, non-toxic homocysteine-lowering treatment with vitamins can reduce the incidence of, or delay the onset of dementia, it would have an enormous impact in societies with a rapidly increasing number of elderly at risk for dementia. This book summarises the research within the neuropsychiatric field, but also gives an overview of the underlying biochemistry and of diagnostic aspects.
