Refine Results
Sort By
From
To
Page 1
Page 1
Manual of intracytoplasmic sperm injection in human assisted reproduction
For around half of the couples who have trouble conceiving the cause of infertility is sperm-related. Intracytoplasmic sperm injection (ICSI) is the most common and successful treatment for male infertility. Here, the pioneers for the technique, along with authorities in the field, describe the underlying science of ICSI and other micromanipulation techniques. Practical advice for performing the techniques is covered in depth, including sperm selection, laser-assisted ICSI, and the use of piezo in ICSI. Examining the safety of ICSI in animal models as well as the impact of ICSI on the health and well-being of the children conceived through the procedure is discussed. This manual is an essential resource for clinical embryologists and laboratory personnel wishing to refine or develop techniques and improve outcomes.
Comparative Placentation : Structures, Functions and Evolution
Science produces fascinating puzzles: why is there such a range of placental structures when other mammalian organs are so structurally uniform ? Why and how did the different placental structures evolve ? Comparative placental studies can facilitate the identification of the common factors in placental growth, differentiation and function and their relevance to possible evolutionary pathways. Comparative Placentation is the only book presenting up-to-date data illustrating the great variety of structure but uniform function of vertebrate placentas from fish to man. This information is essential for selection of suitable models to investigate particular practical problems of impaired or anomalous growth in human and animal placentation. The unique collection of the best light and electron micrographs from the last thirtyfive years which precisely illustrate the structural range in each taxon, make the book the most authoritative publication in this field and a vital source of information for anyone interested on reproductive physiology, anatomy and medicine.
Community pharmacy : symptoms, diagnosis and treatment
Support pharmacists in identifying, diagnosing, treating or referring the illnesses and conditions they will commonly encounter in the community. A logical structure covers the full range of common presentations, including respiratory, ear, eye, gastroenterological and skin conditions. Clear pictures, referral criteria and summaries of treatment options support clinical reasoning, differential diagnosis and selection of appropriate products. Suitable for both pharmacy students and qualified pharmacists, the sixth edition has been fully updated to align with changes to the pharmacy curriculum and the rapidly expanding scope of pharmacists working in primary care and community pharmacy.
Clinical Functional MRI : Presurgical Functional Neuroimaging
Functional magnetic resonance imaging (fMRI) has contributed significantly to progress in neuroscience by permitting noninvasive imaging of the "human brain at work" under physiological conditions. Within clinical neuroimaging, fMRI is opening up a new diagnostic field by measuring and visualizing brain function. However, fMRI is not yet a standard diagnostic imaging procedure. This textbook is devoted to preoperative fMRI in patients with brain tumors and epilepsies, which are the most well-established clinical applications. By localizing and lateralizing specific brain functions in individual patients, as well as epileptogenic zones, fMRI facilitates the selection of a safe treatment and the planning and performance of function-preserving neurosurgery.
Chemical Biology and Drug Discovery
Gives the reader, through the specific selection of chemical-biological techniques and concepts, the necessary tools to be able to develop new ways of thinking and thus new therapeutic options in the complex field of chemical biology and drug development. The stated aim of this book is to provide concrete solutions and inspiration to students, (post)graduate students, and experienced scientists at universities as well as in industry in their problems.
Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts
Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: •Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries •Includes illustrative case studies that review six milestone bio-products •Discuses a wide selection of host strain types and disruptive bioprocess technologies
Biomolecular and bioanalytical techniques : Theory, methodology and applications
Offers an introduction to, and a basic understanding of, a wide range of biophysical techniques. The text takes an interdisciplinary approach with contributions from a panel of distinguished experts. With a focus on research, the text comprehensively covers a broad selection of topics drawn from contemporary research in the fields of chemistry and biology. Each of the internationally reputed authors has contributed a single chapter on a specific technique. The chapters cover the specific technique’s background, theory, principles, technique, methodology, protocol and applications.
Biodiversity and Conservation in Europe
This book brings together a selection of original studies submitted to Biodiversity and Conservation that address biodiversity and conservation in Europe. Europe is certainly the most intensively inventoried region of the world; detailed maps are available for species distributions while action plans are being drawn up for species under threat. At the same time, the wildlife of Europe has been subject to enormous human pressures, with limited ‘wilderness’ sites remaining in most countries. Europe consequently presents a case-study of what the human impact on biodiversity has been, and also what can be done to improve the situation.
Artificial intelligence in drug design
Looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future.
Appropriate Dose Selection - How to Optimize Clinical Drug Development
Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.g., due to concurrent illnesses or co-medications. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. The continued use of biomarkers – based on the (known) pharmacology of the drug and/or biology of the underlying disease – along with exposure–response evaluation throughout all phases of drug development can quantitatively integrate clinical pharmacology knowledge, provide early proof of concept, and help in rational dose selection and rational drug product labeling for clinical use.
About Life : Concepts in Modern Biology
This book uses modern biological knowledge to tackle the question: "What distinguishes living organisms from the non-living world?" In the first few chapters, the authors draw on recent advances in cell and molecular biology to develop an account of the "living state" that applies to all organisms, but only to organisms. Subsequent chapters use this account to explore questions about evolution, the origin of life and the possibility of extraterrestrial life. Towards the end of the book the authors consider human evolution, intelligence and the extent to which our species can be regarded as biologically unique. About Life is written as far as possible in non-technical language; all scientific terms are explained straightforwardly when they are introduced. It is aimed at the general, non-specialist reader, but the novel approach that it takes to general issues in biology will also interest students of the life sciences.
Law and Justice in a globalized world
Consists of a selection of papers presented at the Asia-Pacific Research Conference on Social Sciences and Humanities. It contains essays on current legal issues in law and justice, and their role and transformation in a globalizing world. Topics covered include human rights, criminal law, law of the sea, good governance, democracy, foreign investment, and regional integration. The conference focused on Asia and the Pacific, two regions where law has taken an important position in creating and shaping the regional integrations, new legal institutions, and norms.
Common Law, Civil Law, and Colonial Law : Essays in Comparative Legal History from the Twelfth to the Twentieth Centuries
This volume is a selection of essays taken from the excellent range of papers presented at the British Legal History Conference hosted by the Institute for Legal and Constitutional Research at the University of St Andrews, 10-13 July 2019. The theme of the conference gives this book its title: 'comparative legal history'. The topic came easily to the organisers because of their association with the St Andrews-based European Research Council Advanced grant project 'Civil law, common law, customary law: consonance, divergence and transformation in Western Europe from the late eleventh to the thirteenth centuries'.
Managing Humans : Biting and Humorous Tales of a Software Engineering Manager
Managing Humans is a selection of the best essays from Michael Lopp's web site, Rands in Repose. Drawing on Lopp's management experiences at Apple, Netscape, Symantec, and Borland, this book is full of stories based on companies in the Silicon Valley where people have been known to yell at each other. It is a place full of dysfunctional bright people who are in an incredible hurry to find the next big thing so they can strike it rich and then do it all over again. Among these people are managers, a strange breed of people who through a mystical organizational ritual have been given power over your future and your bank account.
Machine Learning in Computer Vision
The goal of this book is to address the use of several important machine learning techniques into computer vision applications. An innovative combination of computer vision and machine learning techniques has the promise of advancing the field of computer vision, which contributes to better understanding of complex real-world applications. The effective usage of machine learning technology in real-world computer vision problems requires understanding the domain of application, abstraction of a learning problem from a given computer vision task, and the selection of appropriate representations for the learnable (input) and learned (internal) entities of the system. In this book, we address all these important aspects from a new perspective: that the key element in the current computer revolution is the use of machine learning to capture the variations in visual appearance, rather than having the designer of the model accomplish this. As a bonus, models learned from large datasets are likely to be more robust and more realistic than the brittle all-design models.
Linear and Generalized Linear Mixed Models and Their Applications
This book covers two major classes of mixed effects models—linear mixed models and generalized linear mixed models—and it presents an up-to-date account of theory and methods in analysis of these models as well as their applications in various fields. It offers a systematic approach to inference about non-Gaussian linear mixed models. Furthermore, it discusses the latest developments and methods in the field, incorporating relevant updates since publication of the first edition. These include advances in high-dimensional linear mixed models in genome-wide association studies (GWAS), advances in inference about generalized linear mixed models with crossed random effects, new methods in mixed model prediction, mixed model selection, and mixed model diagnostics.
Comprehensive mathematics for computer scientists 2 : Calculus and ODEs, splines, probability, fourier and wavelet theory, fractals and neural networks, categories and lambda calculus
This second volume of a comprehensive tour through mathematical core subjects for computer scientists completes the ?rst volume in two - gards: Part III ?rst adds topology, di?erential, and integral calculus to the t- ics of sets, graphs, algebra, formal logic, machines, and linear geometry, of volume 1. With this spectrum of fundamentals in mathematical e- cation, young professionals should be able to successfully attack more involved subjects, which may be relevant to the computational sciences. In a second regard, the end of part III and part IV add a selection of more advanced topics. In view of the overwhelming variety of mathematical approaches in the computational sciences, any selection, even the most empirical, requires a methodological justi?cation. Our primary criterion has been the search for harmonization and optimization of thematic - versity and logical coherence. This is why we have, for instance, bundled such seemingly distant subjects as recursive constructions, ordinary d- ferential equations, and fractals under the unifying perspective of c- traction theory.
Big Data in Context : Legal, Social and Technological Insights
Sheds new light on a selection of big data scenarios from an interdisciplinary perspective. It features legal, sociological and economic approaches to fundamental big data topics such as privacy, data quality and the ECJ’s Safe Harbor decision on the one hand, and practical applications such as smart cars, wearables and web tracking on the other. Addressing the interests of researchers and practitioners alike, it provides a comprehensive overview of and introduction to the emerging challenges regarding big data.All contributions are based on papers submitted in connection with ABIDA (Assessing Big Data), an interdisciplinary research project exploring the societal aspects of big data and funded by the German Federal Ministry of Education and Research.
Automated machine learning : Methods, systems, challenges
This book presents the first comprehensive overview of general methods in Automated Machine Learning (AutoML), collects descriptions of existing systems based on these methods, and discusses the first series of international challenges of AutoML systems. The recent success of commercial ML applications and the rapid growth of the field has created a high demand for off-the-shelf ML methods that can be used easily and without expert knowledge. However, many of the recent machine learning successes crucially rely on human experts, who manually select appropriate ML architectures (deep learning architectures or more traditional ML workflows) and their hyperparameters. To overcome this problem, the field of AutoML targets a progressive automation of machine learning, based on principles from optimization and machine learning itself.
Artificial intelligence in the design process : The impact on creativity and team collaboration
Discusses how to include artificial intelligence (AI) systems in the early stages of the design process. Today designers need new tools capable of supporting them in dealing with the increasing project's complexity and empowering their performances and capabilities. AI systems appear to be powerful means to enhance designers' creativity. This assumption was tested in a workshop where sixteen participants collaborated with three AI systems throughout the creative phases of research, sketching, and color selection. Results show that designers can access a broader level of variance and inspiration while reducing the risk of fossilization by triggering lateral thinking through AI-generated data. Therefore, AI could significantly impact the creative phases of the design process if applied consciously. Being AI systems intelligent agents, the book treats the Human-AI collaboration as a collaboration between human agents, proposing a set of guidelines helpful to achieving an efficient partnership with the machine.
