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Les douleurs abdominales en questions : Rôle physiopathologique de la sensibilité viscérale = Abdominal pain in question : The pathophysiological role of visceral sensitivity
The gut-brain axis refers to the network of nerve pathways that connect the myenteric plexus, the veritable "gut brain," to the central nervous system. Nearly 80% of these neurons are sensory neurons, and the afferent pathways that transmit information from the digestive tract to the central nervous system play a crucial role in the physiological regulation of digestive functions, as well as in certain pathological conditions. A large majority of these sensations remain unconscious and give rise to reflex responses. Only those requiring a conscious response reach the level of awareness in a normal state (hunger, thirst, the urge to defecate). In pathological situations, the same is true for painful sensations of digestive origin. Functional bowel disorders are a frequent reason for consultation. Their pathophysiology is now based on a model integrating the various etiological factors around the brain-gut axis. These patients frequently present with visceral hypersensitivity, which manifests as an increased perception of digestive sensations, notably the onset of pain in response to stimuli that are not painful in normal subjects. Recognizing the role of visceral hypersensitivity has made it possible to explain the mechanism of action of medications used to treat functional bowel disorders and paves the way for the development of new molecules acting on digestive afferents. In this book, we will describe the anatomical and physiological basis for understanding the concept of visceral sensitivity and the role of digestive afferents in the pathophysiology of acute and chronic abdominal pain, particularly irritable bowel syndrome.
Change from the Inside Out : Making you, your team, and your organization change-capable
Change initiatives fail because humans are hardwired to return to what's worked for them in the past. This book offers a straightforward process for building support for change from the ground up
Cities between competitiveness and cohesion : Discourses, realities and implementation
The book shows that spatial and urban policy continues to be a key site of policy intervention and experimentation. Different national welfare systems, political cultures, and socio-economic conditions combine and recombine to address policy problems and opportunities. Collectively, the authors argue that the examined policy initiatives reflect and reproduce these broader changes and shifting ways of thinking about the appropriate relationships between citizens, businesses, and the state.
Biological Membrane Ion Channels : Dynamics, Structure, and Applications
Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts.
Automatic Autocorrelation and Spectral Analysis
It takes advantage of greater computing power and robust algorithms to produce enough candidate models to be sure of providing a suitable candidate for given data. Improved order selection quality guarantees that one of the best (and often the best) will be selected automatically. The data themselves suggest their best representation. Should the analyst wish to intervene, alternatives can be provided. Written for graduate signal processing students and for researchers and engineers using time series analysis for practical applications ranging from breakdown prevention in heavy machinery to measuring lung noise for medical diagnosis.
