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Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
Presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.
Ion channels as targets in drug discovery
Built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience
Handbook of neurochemistry and molecular neurobiology : Sensory neurochemistry
This volume of the Handbook of Neurochemistry and Molecular Biology focuses on molecular events involved in synapse formation, synaptic plasticity and ongoing neural activity. The volume explores axonal growth cones, synapse development, and mechanisms of LTP and LTD, and calcium dynamics.
Handbook of neurochemistry and molecular neurobiology : Practical neurochemistry methods
The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition
Handbook of neurochemistry and molecular neurobiology : Neurotransmitter Systems
The brain is the organ that collects information from the environment, processes and stores the information, and generates behavior as and when needed. In essence, the brain makes us who we are. For this reason, understanding the biology of brain function is a great challenge and a major goal of modern science. The brain is one of the last great frontiers in science, and the unraveling of its mysteries is comparable in complexity to efforts in space exploration. A fundamental goal of neuroscience is to understand how neurons generate behavior and the pathophysiology of different mental and neurological diseases. This requires, among other things, information about where these neurons are located, how they are connected, and how they communicate with each other in various physiological and pathophysiological conditions. Our aim is to describe recent discoveries about the basic operations of the brain and to provide an introduction to the adaptations for specific types of information processing.
Handbook of neurochemistry and molecular neurobiology : Neuroimmunology
Neuroimmunology is one of the most rapidly developing branches of Neurobiology, and this volume contains chapters that focus on a huge range of topics including the relationship between neuroimmunology and the pathogenesis of different nervous diseases.
Handbook of neurochemistry and molecular neurobiology : Neural Protein Metabolism and Function
This volume discusses aspects of neural protein metabolism. Although this subject is clearly very important and has numerous functional aspects, it did not always get the attention it clearly deserves. Perhaps there are many explanations for researchers hesitating in the past to focus on protein metabolism.
Handbook of neurochemistry and molecular neurobiology : Neural Membranes and Transport
The first section of this volume deals with neural membranes and barriers. The second section covers ion pumps and ion transporters in neural membranes. The final section covers neural membranes and transport of neurotransmitters or other solutes.
Handbook of neurochemistry and molecular neurobiology : Development and Aging Changes in the Nervous System
In the animal nervous system, a very high metabolic turnover, fragile but steep ionic gradients, and morphological and structural constraints - dictated by the necessity for prompt neuronal transmission of electrical impulses and necessary plasticity - result in a highly fragile organ system. Here, we address a small sampling of major constituents of neural function at the cellular and molecular level that play important roles in development and aging, two endogenous processes that embody features of allostasis or the dynamic shifts in set points for specific homeostatic mechanisms associated with development and aging. These chapters stress the dynamic features of neuronal responses to internal (developmental) cues or the more harmful external events (injury and disease) in a modern perspective.
Handbook of neurochemistry and molecular neurobiology : Degenerative Diseases of the Nervous System
The Second Edition of the Handbook of Neurochemistry, which was published about 24 years ago, consisted of 10 volumes. In addition to metabolic processes, the 17 new volumes explore the functions of peptides, transport, immunology and other processes not well understood 24 years ago.
Handbook of neurochemistry and molecular neurobiology : Brain Energetics. Integration of Molecular and Cellular Processes
Focuses on aspects of energy metabolism that are unique to the brain. The goal of each chapter is to provide a fundamental overview of each area, to define the state-of-the-art in that area as it relates to brain, and, where appropriate, describe models that portray poorly understood and apparently contradictory data sets with the goal of helping focus attention to experimental resolution of controversial issues.
Handbook of neurochemistry and molecular neurobiology : Behavioral Neurochemistry, Neuroendocrinology and Molecular Neurobiology
The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition.
Handbook of neurochemistry and molecular neurobiology : Amino acids and peptides in the nervous system
It is our belief that this volume of the Handbook of Neurochemistry and Molecular Neurobiology provides an excellent review of the tremendous advances of the past decades in the neurochemical and molecular biological aspects of cerebral ischemia. It is hoped that these advances will provide an impetus for basic scientists and clinicians to further their translational research and to promote the insights for development of therapeutic interventions for stroke.
Handbook of neurochemistry and molecular neurobiology : Acute Ischemic injury and repair in the nervous system
It is our belief that this volume of the Handbook of Neurochemistry and Molecular Neurobiology provides an excellent review of the tremendous advances of the past decades in the neurochemical and molecular biological aspects of cerebral ischemia. It is hoped that these advances will provide an impetus for basic scientists and clinicians to further their translational research and to promote the insights for development of therapeutic interventions for stroke.
Kindling 6
A broad array of themes concerned with research on epilepsy and kindling is covered in the book: Pathogenesis of kindling, including developmental patterns; electrophysiology; anatomy, morphology, and neural circuitry; genes, species, and strains; synaptic pharmacology and neurochemistry ; Behavioral consequences of kindling ; Drugs and interventions against kindling ; Clinical relevance of kindling for our understanding of epilepsy in patients
