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Artificial intelligence in drug design
Looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future.
Advances in mathematical economics ; Vol. 10
The series is designed to bring together those mathematicians who were seriously interested in getting new challenging stimuli from economic theories with those economists who are seeking for effective mathematical tools for their researchers.
Local and Semi-Local Bifurcations in Hamiltonian Dynamical Systems : Results and Examples
Once again KAM theory is committed in the context of nearly integrable Hamiltonian systems. While elliptic and hyperbolic tori determine the distribution of maximal invariant tori, they themselves form n-parameter families. Hence, without the need for untypical conditions or external parameters, torus bifurcations of high co-dimension may be found in a single given Hamiltonian system. The text moves gradually from the integrable case, in which symmetries allow for reduction to bifurcating equilibria, to non-integrability, where smooth parametrisations have to be replaced by Cantor sets. Planar singularities and their versal unfoldings are an important ingredient that helps to explain the underlying dynamics in a transparent way.
Lectures on Advances in Combinatorics
The main focus of these lectures is basis extremal problems and inequalities – two sides of the same coin. Additionally they prepare well for approaches and methods useful and applicable in a broader mathematical context. Highlights of the book include a solution to the famous 4m-conjecture of Erdös/Ko/Rado 1938, one of the oldest problems in combinatorial extremal theory, an answer to a question of Erdös (1962) in combinatorial number theory "What is the maximal cardinality of a set of numbers smaller than n with no k+1 of its members pair wise relatively prime?", and the discovery that the AD-inequality implies more general and sharper number theoretical inequalities than for instance Behrend's inequality.
Classes of Finite Groups
Many group theorists all over the world have been trying in the last twenty-five years to extend and adapt the magnificent methods of the Theory of Finite Soluble Groups to the more ambitious universe of all finite groups. This is a natural progression after the classification of finite simple groups but the achievements in this area are scattered in various papers.Our objectives in this book were to gather, order and examine all this material, including the latest advances made, give a new approach to some classic topics, shed light on some fundamental facts that still remain unpublished and present some new subjects of research in the theory of classes of finite, not necessarily solvable, groups.
Algorithms in Real Algebraic Geometry
The algorithmic problems of real algebraic geometry such as real root counting, deciding the existence of solutions of systems of polynomial equations and inequalities, finding global maxima or deciding whether two points belong in the same connected component of a semi-algebraic set appear frequently in many areas of science and engineering. In this first-ever graduate textbook on the algorithmic aspects of real algebraic geometry, the main ideas and techniques presented form a coherent and rich body of knowledge, linked to many areas of mathematics and computing.
Algebraic Groups and Lie Groups with Few Factors
Algebraic groups are treated in this volume from a group theoretical point of view and the obtained results are compared with the analogous issues in the theory of Lie groups. The main body of the text is devoted to a classification of algebraic groups and Lie groups having only few subgroups or few factor groups of different type. In particular, the diversity of the nature of algebraic groups over fields of positive characteristic and over fields of characteristic zero is emphasized. This is revealed by the plethora of three-dimensional unipotent algebraic groups over a perfect field of positive characteristic, as well as, by many concrete examples which cover an area systematically. In the final section, algebraic groups and Lie groups having many closed normal subgroups are determined.
Adaptive Multi-Standard RF Front-Ends
Adaptive Multi-Standard RF Front-Ends investigates solutions, benefits, limitations and costs related to multi-standard operation of RF front-ends and their adaptivity to variable radio environments. Next, it highlights the optimization of RF front-ends that allow achieving of maximal performance with a certain power budget while targeting full integration. Also, it investigates possibilities for low-voltage low-power circuit topologies in CMOS technology.
