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Lymphocyte Signal Transduction
Signal transduction through leukocyte receptors involves a variety of signaling molecules including kinases, phosphatases, adaptor proteins, small GTPases GTP exchange factors, membrane phospholipids as well as others. These signal transducers, regulated by inter- and intra-molecular interactions, as well as by various post-translational modifications, lead to the activation of transcription factors that mediate cellular differentiation and growth, effector cell functions, and apoptotic cell death. Several investigators from various parts of the world convened at the 3rd Lymphocyte Signal Transduction Workshop in Crete, Greece from May 27 to June 1, 2005 to discuss their most recent findings in leukocyte signaling. This volume represents a collection of topics discussed during the conference.
Cell-Cycle Mechanisms and Neuronal Cell Death
This book serves to gain new insights into the molecular determinants of neuronal death and to establish new targets for therapeutic intervention.
Cell Engineering : Apoptosis
A reference on the development of cellular systems for the production of recombinant glycoproteins, gene and cell therapies, drug screening and tissue engineering. It intends to review the in-depth assessments of this type of programmed cell death. It is suitable for biotechnologists and researchers in apoptosis, cell biology, and cell culture.
Brain Repair
Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics.
Auditory Trauma, Protection, and Repair
Protection and Repair presents recent developments in auditory research and their potential translation to the clinical setting. In particular the authors address the major entities of peripheral auditory trauma, discuss the underlying mechanisms, the central nervous system consequences, protective interventions and finally explore the possibilities to restore cochlear morphology and function.Two themes run through the chapters in this book: cellular homeostasis and cell death. In the broadest sense, all auditory pathologies are disorders of cellular homeostasis.
Application of Apoptosis to Cancer Treatment
This book is intended for workers in the field and clinicians as a useful guide of the state of affairs in this exciting field which may offer more effective possibilities for treatment of cancer patients.
Apoptotic pathways as targets for novel therapies in cancer and other diseases
The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients.
Apoptosis, Senescence, and Cancer
Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers.this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment.
Apoptosis, cell signaling, and human diseases : Molecular mechanisms ; Vol.2
Volume 1 is divided into two sections: "Malignant Transformation and Metastasis" and "Molecular Basis of Disease Therapy." Volume 2 follows a similar structure and is divided into sections entitled "Kinases and Phosphate" and "Molecular Basis of Cell Death." All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.
Apoptosis, cell signaling, and human diseases : Molecular mechanisms ; Vol.1
Volume 1 is divided into two sections: “Malignant Transformation and Metastasis” and “Molecular Basis of Disease Therapy.” Volume 2 follows a similar structure and is divided into sections entitled “Kinases and Phosphate” and “Molecular Basis of Cell Death.” All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.
Abl Family Kinases in Development and Disease
Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.
Abeta Peptide and Alzheimers Disease : Celebrating a Century of Research
Abeta Peptide and Alzheimer’s Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer’s Disease (AD), shown by recent advances in genetics and brain biochemistry.the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although specifically focusing on Aß and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases.
