Page 1
Page 1
Thermodynamics for drug product design : A guide for pharmaceutical scientists
Provides real-life drug product design examples, applications, personal anecdotes, and solved problems that contextualize thermodynamic principles for the drug product design scientist. Advanced undergraduate and beginning graduate students will learn to apply thermodynamic principles to create robust drug products and to predict, prevent, analyze, and evaluate the root cause of product failures. Professionals engaged in drug product design will find this book to be a rich and easy to use reference guide.
Surface Chemistry in Biomedical and Environmental Science
In September 2005 a NATO Advanced Research Workshop convened in Kiev to discuss the current state of the art in surface chemistry and nanomaterials research, with a view towards biomedical and environmental applications. This volume represents the fine work presented at this workshop, consisting of a unique mixture of reviews as well as primary research articles from leading laboratories in Eastern and Western Europe as well as the US.
Solid self micro emulsifying drug delivery system
Explores the formulation of Solid Self-Microemulsifying Drug Delivery Systems (SSMEDDS) as a strategy to enhance oral bioavailability and reduce GI side effects of NSAIDs. Tiaprofenic acid, a poorly soluble acidic NSAID, was selected as a model drug to develop and evaluate the delivery system. Excipients were selected using Hansen solubility parameters. While castor oil showed optimal solubility, it was excluded due to known irritancy. Olive oil was chosen for its adequate solubilization capacity and documented gastric protective effects. The optimized SMEDDS formulation was solidified via adsorption on Aerosil.
Smart Colloidal Materials
Smart Colloidal Materials Volume covers a broad field including the investigation of synthesis and properties of advanced temperature sensitive particles and their biomedical applications, drug delivery systems, foams, capsules, vesicles and gels, polyelectrolytes, nanoparticles surfactants and hybrid materials. … these volumes address issues that researchers actually struggle with when they are working on polymer surfaces and thin films and colloidal materials. … ideal for experienced researchers who need to catch up with these newer methods and trends. Terrifically useful volumes in the publisher’s series.
Sediment Dynamics and Pollutant Mobility in Rivers : An Interdisciplinary Approach
In the ten chapters of this book, a broad set of practical process knowledge is p- sented, comprising simulation techniques, laboratory and in-situ studies on the int- action between biological, chemical and hydrodynamic factors as well as models, for solving combined quality and quantity problems of riverine sediments. The und- lying research on various types of particulate matter, risk analyses and problem - lutions will also contribute to the implementation of the Soil Strategy and – in p- ticular – Marine Strategy Directive in Europe.
Rugged Free Energy Landscapes : Common Computational Approaches to Spin Glasses, Structural Glasses and Biological Macromolecules
This collection of lectures and tutorial reviews by renowned experts focusses on the common computational approaches in use to unravel the static and dynamical behaviour of complex physical systems at the interface of physics, chemistry and biology. Paradigmatic examples of condensed matter physics are spin and structural glasses and protein folding, as well as their aggregation and adsorption to hard and soft surfaces, in physico-chemical biology.
Recent Advances in the Theory of Chemical and Physical Systems ; Proceedings of the 9th European Workshop on Quantum Systems in Chemistry and Physics (QSCP-IX) held at Les Houches, France, in September 2004
Advances in the Theory of Chemical and Physical Systems is a collection of 26 selected papers from the scientific presentations made at the 9th European Workshop on Quantum Systems in Chemistry and Physics (QSCP-IX) held at Les Houches, France, in September 2004. This volume encompasses a spectrum of developing topics in which scientists place special emphasis on theoretical methods in the study of chemical and physical properties of various systems.
Recent Advances in Adsorption Processes for Environmental Protection and Security
The purpose of the Workshop was to bring together researchers and engineers working in adsorption related fields, to share knowledge on the latest advances on adsorption processes for environmental security and protection, as well as to cross link and disseminate to the scientific community the main results and achievements of recent NATO SfP projects on environmental security and protection. Topics covered by the Workshop include recent theoretical and experi mental developments on environmental adsorption, adsorption processes, as well as synthesis and tailoring of novel adsorbents, including the assessment of materials and processes.
Reactive Transport in Soil and Groundwater : Processes and Models
Technologies for soil remediation require real knowledge and understanding of the processes involved and a correct and complete numerical approach in order to reach the best results at the lowest possible cost. The authors focus on the improvement of the scientific base for the development of integrated indicators of the environmental risks created by the presence of pollutants in water and porous media. They deliver insights into the understanding of integrated process, and also modeling capabilities. The establishment of a set of integrated indicators to evaluate the pollution status and risk of water resources will considerably aid environmental agencies, administrators and regulators and profit the society as a whole.
Raman and SERS Investigations of Pharmaceuticals
Exemplifies such interdisciplinary work. Thus, some new derivatives have been prepared by chemists and consecutively analyzed by physicists in order to better understand their physical-chemical properties for future tests to be performed by pharmacists. The book consists of an introductory section and other eight chapters. First, the fundamentals of infrared, Raman and surface enhanced Raman spectroscopy and those of the theoretical methods employed for the vibrational prediction modes are highlighted. The SERS investigations illustrated in the following chapters are focused on different kinds of drugs: tranquilizers and sedatives, anti-inflammatory drugs, vitamins, drugs with anti-bacterial properties, etc.
Quantum Chemistry of Solids : The LCAO First Principles Treatment of Crystals
Quantum Chemistry of Solids delivers a comprehensive account of the main features and possibilities of LCAO methods for the first principles calculations of electronic structure of periodic systems.
Proteins at Solid-Liquid Interfaces
The adsorption of proteins at interfaces plays a role in many fields, suchas health, food, environment and analysis. Fundamental aspects are usefulwhen considering applications. We focus here especially on solid–liquidinterfaces and present a few fundamental studies regarding adsorption ki-netics and conformational changes, and examples of applications to sensorsand membranes.The first part is dedicated to fundamental studies performed using op-tical waveguide lightmode spectroscopy, as an example of a technique thathas the advantage of not requiring labelled proteins, but is limited to spe-cific supports.The second part includes different bench techniques that were devel-oped to improve the sensitivity of the characterisation of the orientationand structure of the proteins at interfaces.
Polyelectrolytes and Nanoparticles
Guides chemists through demonstrations of synergistic effects between polyelectrolytes and nanoparticles. After a short introduction into the field of polyelectrolytes and polyelectrolyte characterization, the role of polyelectrolytes in the process of nanoparticle formation is discussed in more detail. However, polyelectrolytes can directly influence the growing of nanoparticles and also can stabilize the nanoparticles formed. Therefore, the nanoparticle formation in polyelectrolyte-modified template phases, e.g. microemulsions, is of growing interest. Finally, methods for characterization of the polyelectrolyte-modified nanoparticles are explained. The adsorption of polyelectrolytes can be detected by measuring the zeta potential at the nanoparticle surface by means of electrophoretic light scattering, acoustophoresis or streaming potential measurements.
Piezoelectric Sensors
Chemically and biologically functionalized piezoelectric sensors are attractive alternatives to surface-sensitive transducers due to their surpassing versatility. The fourth volume of the Springer Series on Chemical Sensors and Biosensors includes a comprehensive theoretical treatment and current state-of-the art applications of the quartz crystal microbalance (QCM). Interface circuits and the study of viscoelasticity and micromechanics as well as surface roughness with the QCM are discussed. The broad field of analytical applications of piezoelectric sensors is covered, which ranges from nucleic acid detection, immunosensors, protein-membrane interactions and monitoring cells by imprinted polymers to the viscoelastic response of living mammalian cells on QCM-resonators.
Physics of Surfaces and Interfaces
This graduate-level textbook covers the major developments in surface sciences of recent decades, from experimental tricks and basic techniques to the latest experimental methods and theoretical understanding. It is unique in its attempt to treat the physics of surfaces, thin films and interfaces, surface chemistry, thermodynamics, statistical physics and the physics of the solid/electrolyte interface in an integral manner, rather than in separate compartments. The Physics of Surfaces and Interfaces is designed as a handbook for the researcher as well as a study-text for graduate students in physics or chemistry with special interest in the surface sciences, material science, or the nanosciences. The experienced researcher, professional or academic teacher will appreciate the opportunity to share many insights and ideas that have grown out of the author's long experience. Readers will likewise appreciate the wide range of topics treated, each supported by extensive references. Graduate students will benefit from the elementary introductions to experimental techniques and the clear presentations of the theory behind the techniques and the phenomena. Wherever possible, physical concepts are emphasized and the mathematical notation kept to a minimum; the verbal explanations are supported by 350 graphs and illustrations.
Photocatalytic Reaction Engineering
Heterogeneous photocatalysis is a novel technique for water purification. Publications on photocatalysis span a relatively recent period of not more than 25 years. This is a technique that, according to our extensive experience on the development of laboratory scale and pilot plant units, has great promise to eliminate water and air pollutants. Photocatalysis offers much more than competitive techniques where pollutants are transferred from phases; photocatalysis can achieve complete mineralization of pollutants leaving non-toxic species such as CO2 and H2O and can be exploited at close to room temperature and ambient pressure.
Neutron Scattering in Biology : Techniques and Applications
The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.
Nanostructures : Fabrication and Analysis
The main theme of this book is the exploration the underlying physical laws that permit the fabrication of nanometer-scale structures. As researchers attempt to fabricate nanometer-scale structures which do not exist per se, they must still employ the natural laws to fabricate them through processes such as self-assembly. So it turns out that our techniques for fabrication of nanometer-scale structures are not artificial but actually rely on the natural laws. We even find that nanometer-scale structures, e.g. fullerenes, are fabricated in nature beneath the surface of the Earth. This fact may be called the ubiquity of the nanometer-scale structures. The topics presented in the book include: scanning probe-related and near-field techniques, nanolithography, self assembling and design of novel nanostructures, as well as new nanodevices and their application.
Ionic Soft Matter : Modern Trends in Theory and Applications; Proceedings of the NATO Advanced Research Workshop on Ionic Soft Matter: Modern Trends in Theory and Application Lviv, Ukraine, 14-17 April, 2004
Consists of reviews of the experimental, theoretical and simulation studies on ionic criticality, polyelectrolytes, proton transport in fuel cell membranes, and the design of DNA arrays. This book deals with discussions of the fundamental and applied problems of important phenomena such as ion association, ion adsorption, ion solvation.
Interfacial Processes and Molecular Aggregation of Surfactants
Given the enormous interest in surface phenomena in areas ranging from materials science to applications in life science, this volume is a very timely addition to the literature. Emphasis is on surfactants mediating interfacial and molecular aggregation phenomena, and the following topics are reviewed in particular: dissolution rates, equilibrium adsorption, mixing rules, and spreading on a solid surface of surfactants, as well as the role of surfactants in mediating a range of processes, such as the fabrication of various nanomaterials.
