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Good Research Practice in Non-Clinical Pharmacology and Biomedicine
This book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
Geotechnical Earthquake Engineering
This book presents all issues of earthquake geotechnical engineering in a comprehensive way. It summarizes the present knowledge on earthquake hazards and their causative mechanisms, experimental studies on nonlinear complex soil behaviour, an analysis to predict ground behaviour during earthquakes, field studies to determine nature of real ground as input data for analysis, and damage mitigation technologies.
Genetic control of neuronal migrations in human cortical development
Introduction Cortical development is a complex, tightly regulated process that eventually leads to the six-layered adult human neocortex, the substrate of the unique cognitive, emotional, and social abilities of our species. The basic mechanisms of early cortical development are believed to be very similar among mammals, which has led to a tendency of extrapolating experimental data from rodents on humans.
Genes, development, and cancer : The life and work of Edward B. Lewis
Edward B. Lewis' science is the bridge linking experimental genetics as conducted in the first half of the twentieth century, and the powerful molecular genetic approaches that revolutionized the field in its last quarter. For the first time Lewis' key publications in the fields of genetics, developmental biology, radiation and cancer are compiled within one volume.
General Principles of Tumor Immunotherapy : Basic and Clinical Applications of Tumor Immunology
Brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated through both experimental clinical trials and review of current standard of care therapeutic agents. This information will be invaluable to both students of immunology and cancer research and practicing physicians who have patients with cancer. The book provides a comprehensive overview of the field, demonstrates how advances in basic immunology can and are being applied to cancer, and describes the current status of approved immunotherapy regimens.
Gene Expression and Regulation
This book offers a comprehensive look into the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. Presented in the following five sections, this book covers a full spectrum of topics: The History; The Machinery; The Regulators; The Genome; and Special Topics. The Machinery section covers the transcriptional apparatus and general transcription factors. The Regulators section examines selected gene-specific transcription factors important to regulating gene expression. The Genome section covers issues relevant to the behavior of the genome in relation to gene regulation. The Special Topics section discusses several selected topics ranging from bacterial and plant gene expression to DNA topology and interference RNA. The book’s focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.
Gas Adsorption Equilibria : Experimental Methods and Adsorptive Isotherms
This book is intended to present for the first time experimental methods to measure equilibria states of pure and mixed gases being adsorbed on the surface of solid materials. It has been written for engineers and scientists from industry and academia who are interested in adsorption-based gas separation processes and/or in using gas adsorption for characterization of the porosity of solid materials.Special emphasis is given to uncertainties of data and pros and cons of all measurement methods are offered.
Fuzzy Logic and Applications ; Vol. 2955 ; 5th International Workshop, WILF 2003, Naples, Italy, October 9-11, 2003, Revised Selected Papers
This volume constitutes the thoroughly refereed post-workshop proceedings of the 5th International Workshop on Fuzzy Logic and Applications held in Naples, Italy, in October 2003. The 40 revised full papers presented have gone through two rounds of reviewing and revision. All current issues of theoretical, experimental and applied fuzzy logic and related techniques are addressed with special attention to rough set theory, neural networks, genetic algorithms and soft computing.
Fundamentals of the Physics of Solids ; Vol. I : Structure and Dynamics
This book aims to deliver a comprehensive and self-contained account of the vast field of solid-state physics. It goes far beyond most classic texts in the presentation of the properties of solids and experimentally observed phenomena, along with the basic concepts and theoretical methods used to understand them and the essential features of various experimental techniques.
Fundamentals of Semiconductors : Physics and Materials Properties
This third updated edition of Fundamentals of Semiconductors attempts to fill the gap between a general solid-state physics textbook and research articles by providing detailed explanations of the electronic, vibrational, transport, and optical properties of semiconductors. The approach is physical and intuitive rather than formal and pedantic. Theories are presented to explain experimental results. This textbook has been written with both students and researchers in mind. Its emphasis is on understanding the physical properties of Si and similar tetrahedrally coordinated semiconductors. The explanations are based on physical insights. Each chapter is enriched by an extensive collection of tables of material parameters, figures, and problems. Many of these problems "lead the student by the hand" to arrive at the results.
Fundamentals of nanoscale film analysis
The book describes the fundamentals of materials characterization from the standpoint of the incident photons or particles which interrogate nanoscale structures. These induced reactions lead to the emission of a variety of detected of particles and photons. It is the energy and intensity of the detected beams that is the basis of the characterization of the materials. The array of experimental techniques used in nanoscale materials analysis covers a wide range of incident particle and detected beam interactions.
Fundamentals in Nuclear Physics : From Nuclear Structure to Cosmology
Explores nuclear physics and its applications ranging from the structure of nuclei and their reactions, to astrophysics and cosmology. The physics is introduced with arguments based on simple ideas such as the empirical structure of nuclear forces and its interplay with the Pauli principle and Coulomb repulsion. The book then develops elementary nuclear models and illustrates nuclear systematics with experimental data. Reactions and decays are discussed both phenomenologically and from the point of view of fundamental electro-weak interaction theory. The discussions of fission and fusion emphasize nuclear energy production. This leads directly into nuclear astrophysics and nucleosynthesis. The book ends with a presentation of the latest ideas about cosmology. As a primer this course will lay the foundations for more specialized subjects within the vast domain of nuclear physics as a whole. This book emerged from a series of topical courses the authors delivered at the Ecole Polytechnique and will be useful for advanced undergraduates and for scientists in a variety of fields.
Functional MRI : Basic principles and clinical applications
This practical and timely volume presents an overview of the principles of fMRI and explains key concepts, including scanning methodologies, experimental research design, and data analysis. Informative discussions cover the technical and clinical challenges associated with fMRI. A neuroanatomical atlas adds to the sensible approach and serves as a useful reference by clearly illustrating normal functioning for important areas of the brain.
Functional Approach to Optimal Experimental Design
The book presents a novel approach for studying optimal experimental designs. The functional approach consists of representing support points of the designs by Taylor series. It is thoroughly explained for many linear and nonlinear regression models popular in practice including polynomial, trigonometrical, rational, and exponential models. Using the tables of coefficients of these series included in the book, a reader can construct optimal designs for specific models by hand. The book is suitable for researchers in statistics and especially in experimental design theory as well as to students and practitioners with a good mathematical background.
Fuel Cells : From Fundamentals to Applications
Fuel Cells: Fundamentals to Applications is a concise source of the basic electrochemical principles and engineering aspects involved in the development and commercialization of fuel cells. It describes the applications and techno-economic assessment of fuel cell technologies along with an in-depth discussion of conventional and novel approaches pursued for generating energy. This book is divided into four parts. Parts I and II explain basic and applied electrochemistry relevant to an understanding of fuel cells. Part III covers engineering and technology aspects and Part IV, applications and economics. The first part covers, in detail, the electrode kinetics and electrocatalysis of charge-transfer reactions, and leading electrochemical technologies with focus on relevance to fuel cells. The second part addresses the governing principles of fuel cells, electrocatalysis of fuel cell reactions and experimental techniques pertinent to fuel cell research and development. The third part is devoted to modeling of fuel cell systems and a thorough discussion of fuels, fuel processing and fuel storage, transmission, and distribution. The final part deals with the status of the fuel cell technologies, their applications and economics.
Frontiers in Planar Lightwave Circuit Technology : Design, Simulation, and Fabrication
This book is the result of the NATO Advanced Research Workshop on Frontiers in Planar Lightwave Circuit Technology, which took place in Ottawa, Canada from September 21-25, 2004. In this volume the reader will find detailed overviews of experimental and theoretical work in high index contrast waveguide systems, micro-optical resonators, nonlinear optics, and advanced optical simulation methods, as well as articles describing emerging applications of integrated optics for medical and biological applications.
Frontiers in Magnetic Materials
Frontiers in Magnetic Materials focuses on the current achievements and state-of-the-art advancements in magnetic materials. Several lines of development- High-Tc Superconductivity, Nanotechnology and refined experimental techniques among them – raised knowledge and interest in magnetic materials remarkably. The book comprises 24 chapters on the most relevant topics written by renowned international experts in the field. It is of central interest to researchers and specialists in Physics and Materials Science, both in academic and industrial research, as well as advanced students.
From parity violation to hadronic structure and more : Refereed and selected contributions from Grenoble, France, June 8-11, 2004
Almost 50 years after the proposal of Lee and Young in 1956 to test the hypothesis of parity violation in weak interactions and the subsequent experimental verification of parity violation by C. S. Wu, parity violation has today become a useful property of weak interactions. This is due to the fact that the focus nowadays has changed: parity violation in weak interactions is no more a topic of investigation but is used as a tool in many different fields ranging from nuclear physics to the search for the hidden extra dimensions requested by string theory. For our first workshop which took place June 5-8, 2002, at the Institut fiir Ke- physik of the Johannes Gutenberg-Universitat Mainz, we concentrated on the in vestigation of the strangeness contribution in the nucleon. This book contains the refereed and selected papers of the second workshop "From Parity Violation to Hadron Structure and more (Part II)", which took place June 8-11, in the Labo- toire de Physique Subatomique et de Cosmologie, in Grenoble. These papers appear in EPJAdirect, the electronic-only part of EPJA, and they are accessible without restrictions. They will also appear in printed form and can be ordered through Springer. The excellent presentations show the dramatic and steady progress in the accuracy of measured parity violating asymmetries over the last few years.
From Nucleons to Nucleus : Concepts of Microscopic Nuclear Theory
From Nucleons to Nucleus deals with single-particle and collective features of spherical nuclei. Each nuclear model is introduced and derived in detail. The formalism is then applied to light and medium-heavy nuclei in worked-out examples, and finally the acquired skills are strengthened by a wide selection of exercises, many relating the models to experimental data.
From Energetics to Ecosystems : the Dynamics and Structure of Ecological Systems
Ecosystems are complex and enigmatic entities that are ultimately our life support systems. Understanding these systems to the point of being able to predict their behaviour in the face of perturbations requires that researchers adopt a number of strategies that vary in both approach and scale. This book, in a sense, is representative of some of the developments that have unfolded when math and physics met ecology. Here, some of the world’s leading ecologists examine ecosystems from theoretical, experimental, and empirical viewpoints, from energetics to ecosystems. The book begins with simplifying and synthesizing nature’s complex relationships. It then moves on to explore the mapping between food web structure and function and ends with the role of theory in integrating different research areas. From the breadth of systems analyzed to the rigor of approaches taken, this book is not only a useful resource for students and researchers in ecology, but also serves as a fitting tribute to the life and work of Peter Yodzis.
