Page 68
Page 68
Molecular Aspects of the Stress Response
We are extremely happy to present the reader this book containing a summary of a well-known research field, the phenomenon of cellular stress defense from two new angles: networks and membranes.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Molecular analysis of B lymphocyte development and activation
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Modulation of host gene expression and innate immunity by viruses
This book is reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Infection of a naïve (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including an interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. Not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. This interplay of host and virus represents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents. This book is sure to benefit students, scientists, and physicians working in the areas of virology, immunology, microbiology, and infectious diseases.
Modulated Temperature Differential Scanning Calorimetry : Theoretical and Practical Applications in Polymer Characterisation
This book provides both a basic and advanced treatment of the theory of the technique followed by a detailed exposition of its application to reacting systems, blends and semicrystalline polymers by the leaders in all of these fields. It is an essential text for anybody interested in calorimetry or polymer characterization, especially if they have found that conventional DSC cannot help them with their problems.
Modular Algorithms in Symbolic Summation and Symbolic Integration
Brings together two streams in computer algebra: symbolic integration and summation on the one hand, and fast algorithmics on the other hand. In many algorithmically oriented areas of computer science, the analysis of al gorithms placed into the lime light by DonKnuth’stalkat the 1970ICM –provides a crystal-clear criterion for success. The researcher who designs an algorithm that is faster (asymptotically, in the worst case) than any previous method receives instant gratification : her result will be recognized as valuable. Al as, the downside is that such results come along quite infrequently, despite our best efforts. An alternative evaluation method is to run a new algorithm on examples; this has its obvious problems, but is sometimes the best we can do. George Collins, one of the fathers of computer algebra and a great experimenter,wrote in 1969: “I think this demonstrates again that a simple analysis is often more revealing than a ream of empirical data (although both are important). ” Within computer algebra, some areas have traditionally followed the former methodology, notably some parts of polynomial algebra and linear algebra. Other areas, such as polynomial system solving, have not yet been amenable to this - proach. The usual “input size” parameters of computer science seem inadequate, and although some natural “geometric” parameters have been identified (solution dimension, regularity), not all (potential) major progress can be expressed in this framework. Symbolic integration and summation have been in a similar state.
Modern luminescence spectroscopy of minerals and materials
Luminescence Spectroscopy of Minerals and Materials presents an overview of the general concepts in luminescence spectroscopy as well as experimental methods and their interpretation. Special emphasis is laid on the fluorescence lifetime and the determination of time-resolved spectra. This method enables the exposure of new luminescence in minerals previously hidden by more intensive centers. Specialists in the fields of solid state physics, chemistry and spectroscopy will find a wealth of new information in this unique book.
Modern implant dentistry
A comprehensive look at the state of implant dentistry today, equipping beginners and seasoned clinicians alike to improve their skills and practice implant dentistry safely and predictably. The early chapters focus on the biology of dental implants as well as medical considerations required prior to placing them, followed by chapters dedicated to documentation, treatment planning, and digital workflow. Surgical concepts are then described in detail, from single-tooth extraction to guided All-on-X treatment, followed by detailed discussion of the prosthetic options available in implant dentistry. The final chapters include relevant topics such as soft tissue management in implant dentistry, treatment of peri-implant disease, the socket shield technique, and marketing of dental implant therapy. Written by experienced clinicians from all over the world, the book includes over 60 surgical and clinical videos (linked via QR codes) to demonstrate what the procedures and techniques and products look like in real life, not in a photograph taken in ideal conditions, so readers can be confident in their understanding.
Modern Aspects of Electrochemistry ; Vol. 38
Solid State Electrochemistry encompassing modern equilibria concepts, thermodymanics and kinetics of charge carriers in solids.,Electron transfer processes, with special sections devoted to hydration of the proton and its heterogeneous transfer.Electrosorption at electrodes and its relevance to electrocatalysis and electrodeposition of metals,The behavior of Pt and other alloy electrocatalyst crystallites used as the electrode materials for phosphoric acid electrolyte fuel-cells.Applications of reflexology and electron microscopy to the materials science aspect of metal electrodes.Electroplating of metal matrix composites by codeposition of suspended particles, a process that has improved physical and electrochemical properties.
Models, Mysteries, and Magic of Molecules
Molecular behaviour, which is no less than magical, holds the key to the understanding, not only of chemistry, but of all biology and of life itself. It is a mystery why molecular behaviour should remain poorly understood and why the authoritative theories of physics have produced no more than superficial models to elucidate this vital issue. This book explores the common ground to guide chemists, biologists, crystallographers, spectroscopists and theorists into a deeper recognition of their individual relevance towards painting a holistic picture of scientific endeavour. This effort to stimulate interest in multidisciplinary research is rare, if not unique.
Models of the Atomic Nucleus
Models of the Atomic Nucleus is a largely non-technical introduction to nuclear theory – an attempt to explain the nucleus in a way that makes nuclear physics as comprehensible as chemistry or cell biology. Unlike many other scientific fields, the "popularization" of nuclear physics has not previously been successful because many fundamental issues remain controversial and a unified theory of nuclear structure has not yet been established. The theme developed in this book is that the many models of nuclear theory each provide a partial perspective on the nucleus and that the many models can in fact be integrated into a coherent whole and expressed in terms of a lattice of nucleons.
Models in Cooperative Game Theory : Crisp, Fuzzy, and Multi-Choice Games
This book investigates the classical model of cooperative games with transfer able utility (TU-games) and models in which the players have the possibility to cooperate partially, namely fuzzy and multichoice games. In a crisp game the agents are either fully involved or not involved at all in cooperation with some other agents, while in a fuzzy game players are allowed to cooperate with infinitely many different participation levels, varying from non-cooperation to full cooperation. A multichoice game describes an intermediate case in which each player may have a fixed number of activity levels. Part I of the book is devoted to the most developed model in the theory of cooperative games, that of a classical TU-game with crisp coalitions, which we refer to as crisp game along the book. It presents basic notions, solutions concepts and classes of cooperative crisp games in such a way that allows the reader to use this part as a reference toolbox when studying the corresponding concepts from the theory of fuzzy games (Part II) and from the theory of multichoice games (Part III).
Models for Polymeric and Anisotropic Liquids
Models should be as simple as possible, but no simpler. For the physics of polymeric liquids, whose relevant lengths and time scales are out of reach for first principles calculations, this means that we have to choose a minimum set of sufficiently detailed descriptors such as architecture (linear, ring, branched), connectivity, semiflexibility, stretchability, excluded volume, and hydrodynamic interaction. These 'universal' fluids allow the prediction of material properties under external flow- or electrodynamic fields, the results being expressed in terms of reference units, specific for any particular chosen material. This book provides an introduction to the kinetic theory and computer simulation methods needed to handle these models and to interpret the results. Also included are a number of sample applications and computer codes.
Models and Algorithms for Global Optimization : Essays Dedicated to Antanas Žilinskas on the Occasion of His 60th Birthday
The research of Antanas Žilinskas has focused on developing models for global optimization, implementing and investigating the corresponding algorithms, and applying those algorithms to practical problems. This volume, dedicated to Professor Žilinskas on the occasion of his 60th birthday, contains new survey papers in which leading researchers from the field present various models and algorithms for solving global optimization problems.
Modelling water and nutrient dynamics in soil-crop systems : Applications of different models to common data sets - Proceedings of a workshop held 2004 in Müncheberg, Germany
This book contains articles from a workshop on "Modelling water and nutrient dynamics in crop-soil systems". Data sets from lysimeters and experimental fields of multiyear crop rotations were provided for modellers. A unique data set is provided of a 100 year long term field experiment regarding crop yield and organic carbon development under different management systems. The book includes a detailed description of data sets which can be used by modellers and the papers describe the applications of 18 different modelling approaches describing soil-crop-atmosphere interactions for water, nitrogen and carbon dynamics.
Modelling Regional Scenarios for the Enlarged Europe : European Competitiveness and Global Strategies
The aim of this book is to tackle the question of what the European territory will look like over the next fifteen years by providing quali-quantitative territorial scenarios for the enlarged Europe, under different assumptions on future globalisation strategies of BRIC (Brazil, Russia, India and China) and East and West European countries. The approach is as neutral as possible vis-à-vis the results, leaving to a new forecasting model, the MASST model, built by the authors, to produce the tendencies and behavioural paths of regional GDP and population growth in each individual European region under alternative assumptions on the competitiveness strategies of different blocks of countries. The results are accompanied by strong policy messages intended to encourage long-term strategic thinking among a wide range of actors, scientists and policy makers in response to the risks and opportunities that the European territory will face.
Modeling Solid Oxide Fuel Cells : Methods, Procedures and Techniques
The volume is structured in two parts. Part one presents the basic theory, and the general equations describing SOFC operation phenomena. Part two deals with the application of the theory to practical examples, where different SOFC geometries, configurations (from single cells to hybrid systems), operating conditions (steady-state and dynamic), and different phenomena (e.g. performance, temperature and chemical species, and mechanical stress distribution) are analyzed in detail.
Modeling Performance Measurement : Applications and Implementation Issues in DEA
MODELING PERFORMANCE MEASUREMENT: Applications and Implementation Issues in DEA presents unified results from authors’ recent DEA research. These new DEA methodology and techniques are developed in application-driven scenarios that go beyond the identification of the best-practice frontier and seek solutions to aid managerial decisions. These new DEA developments are well-grounded in real world applications. Both DEA researchers and practitioners will find this book helpful. Theory is provided for DEA researchers for further development and possible extensions. However, it should also be mentioned that each theory is presented in practical terms with numerical examples, simple real management cases and verbal descriptions. It is felt that these concrete examples will be of value to researchers, students, and practitioners , This book also provides an easy-to-use DEA software — DEAFrontier (www.deafrontier.com). This DEA software is an Add-In for Microsoft Excel and provides a custom menu of DEA approaches The DEAFrontier does not set limit on the number of units, inputs or outputs.
Modeling in membranes and membrane-based processes
This book explores almost every major aspect of modeling and the techniques applied in membrane separation studies and applications. This includes first principle-based models, thermodynamics models, computational fluid dynamics simulations, molecular dynamics simulations, and artificial intelligence-based modeling for membrane separation processes. These models have been discussed in light of various applications ranging from desalination to gas separation.
Modeling Complex Living Systems : A Kinetic Theory and Stochastic Game Approach
Using tools from mathematical kinetic theory and stochastic game theory, this work deals with the modeling of large complex systems in the applied sciences, particularly those comprised of several interacting individuals whose dynamics follow rules determined by some organized, or even "intelligent" ability. Traditionally, methods of mathematical kinetic theory have been applied to model the evolution of large systems of interacting classical or quantum particles. This book, on the other hand, examines the modeling of living systems as opposed to inert systems.
