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Epigenetics in oncology
Covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years. Individual chapters in Part I (focusing on RNA epigenetics) are devoted to RNA modifications in Cancer Metabolism and Microenvironment, Cancer Stem Cell Biology, Immune Surveillance, Solid Tumors and Tumor Immunity, and Hematopoietic Malignancies, as well as to RNA editing in Cancer. Chapters in Part II and III of the book focus on histone epigenetics and DNA epigenetics, respectively.
Epigenetic Drug Discovery
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.
Enzymes and drugs
Enzyme dysfunction, an essential catalyst for the smooth running of biochemical reactions and the maintenance of vital processes, is at the root of many pathologies that have paved the way for the development of numerous drugs. Aimed at pharmacists, biologists, biochemists, doctors, veterinarians, medicinal chemists and students from a wide range of disciplines, Enzymes and Drugs brings together, for the first time, extensive documentation highlighting the relationships between a large number of drugs and enzymes. The book also highlights new prospects for therapeutic discoveries offered by enzyme targeting. Numerous applications have been developed thanks to strategies for studying enzyme inhibition or activation, as well as the development of allosteric effectors, presented with their advantages and disadvantages. Various rare diseases, known as "orphan" diseases, have resulted from enzyme deficiency or absence. For their treatment, the introduction of substitute enzymes has led to major therapeutic advances.
Enzyme Biocatalysis : Principles and Applications
This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds.
Environments for Multi-Agent Systems ; 1st International Workshop, E4MAS, 2004, New York, NY, July 19, 2004, Revised Selected Papers
The modern ?eld of multiagent systems has developed from two main lines of earlier research. Its practitioners generally regard it as a form of arti?cial intelligence (AI). Some of its earliest work was reported in a series of workshops in the US dating from1980,revealinglyentitled,“DistributedArti?cialIntelligence,”andpioneers often quoted a statement attributed to Nils Nilsson that “all AI is distributed. ” The locus of classical AI was what happens in the head of a single agent, and much MAS research re?ects this heritage with its emphasis on detailed modeling of the mental state and processes of individual agents. From this perspective, intelligenceisultimatelythepurviewofasinglemind,thoughitcanbeampli?ed by appropriate interactions with other minds. These interactions are typically mediated by structured protocols of various sorts, modeled on human conver- tional behavior. But the modern ?eld of MAS was not born of a single parent. A few - searchershavepersistentlyadvocatedideasfromthe?eldofarti?ciallife(ALife). These scientists were impressed by the complex adaptive behaviors of commu- ties of animals (often extremely simple animals, such as insects or even micro- ganisms). The computational models on which they drew were often created by biologists who used them not to solve practical engineering problems but to test their hypotheses about the mechanisms used by natural systems. In the ar- ?cial life model, intelligence need not reside in a single agent, but emerges at the level of the community from the nonlinear interactions among agents. - cause the individual agents are often subcognitive, their interactions cannot be modeled by protocols that presume linguistic competence.
Environmentally Friendly Coastal Protection ; Proceedings of the NATO Advanced Research Workshop on Environmentally Friendly Coastal Protection Structures, Varna, Bulgaria, 25-27 May 2004
Coast lines have been and are the central lines of civilization around the world with increasing pressure from both sides - the hinterland and the sea. This book features papers covering related aspects of Environmentally Friendly Coastal Structures - coast, engineering structures, water, sediments, ecosystems in their complicated interaction
Environmental Simulation Chambers : Application to Atmospheric Chemical Processes
Atmospheric pollution has many different detrimental impacts on air quality at urban, regional and global scales. Large volume photoreactors (often referred to as smog or simulation chambers) have been used very effectively to investigate and understand many varied aspects of atmospheric chemistry related to air pollution problems. Photochemical smog formation, which was first observed around 1945 in Los Angeles, is now a major environmental problem for all industrialised and densely populated regions of the world. Over the years many different modelling and experimental tools have been developed to analyse and simulate the complex chemical processes associated with tropspheric photooxidant formation. Work in environmental chambers has played a key role in the development of our understanding of the atmospheric chemistry associated with pollution problems on local, regional and global scales.
Environmental Security and Sustainable Land Use - with special reference to Central Asia
This book presents important aspects of environmental security and sustainable land use in general and in particular for Central Asia, i.e. the environmental consequences of climate change; sustainable land use and regional development; sustainable development in mountain and steppe regions; beyond borders: Transboundary Biosphere Reserve "Altai" as an approach for regional development; landscape planning as an integrative tool for sustainable development; challenges and threats for environmental stability in Central Asia. A final recommendation in the area of sustainable development and land use as well as the proceeding efforts towards the establishment of the Transboundary Biosphere Reserve "Altai" and the implementation of landscape planning were set in the book as some of the main results of the meeting.
Environmental Security and Public Safety ; Problems and Needs in Conversion Policy and Research after 15 Years of Conversion in Central and Eastern Europe
Although the end of the Cold War has paved the way to a substantial demilitarisation and conversion, the leftovers of this process – such as former military installations, military training areas, and huge quantities of unserviceable ammunition and equipment – still pose a severe threat to the environment of both NATO and Partner countries.The rehabilitation of these areas for civilian uses is extremely costly and is generally in the short and medium term not possible. For this reason, the development of new methods for the estimation avoidance of risks should receive special priority. In the context of this ARW, the reconnaissance and appraisal of conversion areas with respect to costs, returns, and legal considerations were discussed. The decades-long use of some areas led to the heavy loading of contaminates. Every task of conversion has as its goal the elimination of dangers to humans and nature, and the return of areas to civil use, such that these areas can be used realise economic interests of the society.
Environmental Photochemistry ; Part II
Photochemical reactions play a major role in the environment including a wide range of reactions in the atmosphere, natural waters, soil and living organisms. This new volume on Environmental Photochemistry up-dates the previous edition with chapters on basic aspects including concepts of photochemical transformations and mechanistic photochemical processes in the atmosphere and water. In addition a range of applications are also detailed such as advanced photochemical oxidation processes for water and air treatment as well as applications of photocatalysis for surface treatment and nuclear fuel reprocessing. The new edition provides a critical up to date overview of the most important research in the field of environmental photochemistry.
Environmental change and human security : Recognizing and acting on hazard impacts
This book focuses on the linkage between human and environmental security and takes both a conceptual and a pragmatic approach to complex environmental issues (such as soil erosion, desertification, water degradation, demographic shifts, food security and agricultural prospects, urbanization trends, hazard-induced migrations) that affect human security. The book is the direct outcome of a NATO Advanced Research Workshop (ARW), sponsored by the Science for Peace and Security Programme (SPS), Salve Regina University, United Nations Environment Programme (UNEP) and the United States Environmental Protection Agency (EPA). The book summarizes the collective work of both natural and social science disciplines in regard to how best address, mitigate, adapt, or achieve resilience
Environmental Challenges in Civil Engineering II
Rports on findings concerning structural material behavior, and new methods and technologies in constructions. A special emphasis is given to sustainable constructions practices, including material recycling and reuse, renovation and restoration of historical building and to those fostering sustainable development of cities and rural areas, and a better integration of buildings with the environment. Offering a good balance of theory and practice, and covering both technical and organizational aspects in civil engineering and architectural projects, this book offers extensive information on solutions and current challenges in construction projects and structural interventions in the context of environmental protection and earthquake prevention.
Environmental and Microbial Relationships
After the publication of Volume IV in 1997, the introduction of molecular methods into ecology led to significant new findings. Emphasizing these advances, the chapters for the second edition have been completely updated and revised. This volume provides insight into current research on fungal populations and communities. It focuses on fungal responses to the physical environment, interactions with other fungi, microorganisms and invertebrates, the role of fungi in ecosystem processes such as decomposition and nutrient cycling, and aspects of biogeography and conservation. Several chapters deal with various applications in, e.g. biological pest control, natural products discovery, and the degradation of toxic organic compounds. This is an invaluable source of information both for scientists who wish to update their knowledge of current progress and for graduate students interested in obtaining a first overview of this field of research.
Environmental and Health Risk Assessment and Management : Principles and Practices
The book covers the essential aspects of environmental and health law, environmental economics, applied statistical and probabilistic methods, fundamental notions of applied epidemiology and toxicology, as well as decision analysis, to provide an integrated overview of how risk assessment and management combine to produce sound societal outcomes. Risk-based methods play a pivotal role in identifying and ranking alternative, sustainable choices, while accounting for uncertainty and variability. Specifically, most reductions in risks require a balancing of the costs and benefits associated with the action to reduce exposure to a hazard and thus risk. This balancing necessarily involves linking exposure and response through causation. Fundamentally, in risk assessment and management, science and law intersect through legal and scientific causation to the point that the failure to provide a sound causal argument can make an otherwise beneficial law or regulation invalid.
Environment Learning for Indoor Mobile Robots : A Stochastic State Estimation Approach to Simultaneous Localization and Map Building
This monograph covers theoretical aspects of simultaneous localization and map building for mobile robots, such as estimation stability, nonlinear models for the propagation of uncertainties, temporal landmark compatibility, as well as issues pertaining the coupling of control and SLAM. One of the most relevant topics covered in this monograph is the theoretical formalism of partial observability in SLAM. The authors show that the typical approach to SLAM using a Kalman filter results in marginal filter stability, making the final reconstruction estimates dependant on the initial vehicle estimates. However, by anchoring the map to a fixed landmark in the scene, they are able to attain full observability in SLAM, with reduced covariance estimates.
Entropy, Search, Complexity
The present volume is a collection of survey papers in the fields of entropy, search and complexity. They summarize the latest developments in their respective areas.More than half of the papers belong to search theory which lies on the borderline of mathematics and computer science, information theory and combinatorics, respectively. Search theory has variegated applications, among others in bioinformatics. Some of these papers also have links to linear statistics and communicational complexity.
Entropy and Energy : A Universal Competition
Entropy and Energy- a Universal Competition" is a students textbook as well as a scientific monograph. The concepts of entropy and energy embody the effects of random walk in a body and of deterministic strife respectively, and are therefore often in competition. The book gives instructive examples from elementary thermodynamics and physico-chemistry and extrapolates the notion to non-standard thermodynamic subjects like shape memory, dissipation of the earth's atmosphere, and sociology
Entrepreneurship, the new economy and public policy : Schumpeterian perspectives
Silicon Valley is the most salient example of high-tech industrial clusters. Public policy makers throughout the world would like to learn the secrets of Silicon Valley in order to build their own high-tech economies. The existing literature on ind- trial clusters, which traces back to Marshall (1920), focuses on the way in which ?rms bene?t from locating in a cluster; it suggests that once a cluster comes into existence However, a more important question is how to reach this critical mass in the ?rst place. In contrast to the literature, evidence suggests that entrepreneurs rarely move when they est- lish high-tech start-ups. This contradicts the notion that location choice analyses lead entrepreneurs to a high-tech cluster. A high-tech industrial cluster such as Silicon Valley is characterized by c- centrated entrepreneurship.
Entrepreneurship and Business : A Regional Perspective
This book examines the relationship between entrepreneurship, growth and regional aspects of business. The text offers two broad perspectives of entrepreneurship, a historical one and a comparative perspective. In the historical part, several examples of the co-operation between regional aspects and aspects of entrepreneurship are presented. The second part shows different aspects of entrepreneurship in a more and more globalizing world. Networking, the relationship between clusters and business innovation, economic transition and the links between social capital and business competitiveness are some of the topics.
Entrepreneurship : Digital transformation, education, opportunities and challenges ; Vol. 28
Digital transformation and artificial intelligence play an important role in entrepreneurship. this book adopts a multidisciplinary approach to entrepreneurship, exploring how entrepreneurial processes contribute to developing new products and services and innovative business models. recent shifts in business models focus on digital transformation and well-being. entrepreneurship is evolving with innovative approaches, and artificial intelligence is revolutionizing marketing strategies and market engagement. this volume presents a comprehensive overview of entrepreneurship, digital transformation, and entrepreneurial education.
