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Lipids in Health and Disease
Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.
Light Sensing in Plants
Presents overviews of and the latest findings in many of the interconnected aspects of plant photomorphogenesis, including photoreceptors (phytochromes, cryptochromes, and phototropins), signal transduction, photoperiodism, and circadian rhythms, in 42 chapters. Also included, is a prologue by Prof. Masaki Furuya that gives an overview of the historical background.
Lifting Modules : Supplements and Projectivity in Module Theory
Extending modules are generalizations of injective modules and, dually, lifting modules generalize projective supplemented modules. There is a certain asymmetry in this duality. While the theory of extending modules is well documented in monographs and text books, the purpose of our monograph is to provide a thorough study of supplements and projectivity conditions needed to investigate classes of modules related to lifting modules. The text begins with an introduction to small submodules, the radical, variations on projectivity, and hollow dimension. The subsequent chapters consider preradicals and torsion theories (in particular related to small modules), decompositions of modules (including the exchange property and local semi-T-nilpotency), supplements in modules (with specific emphasis on semilocal endomorphism rings), finishing with a long chapter on lifting modules, leading up their use in the theory of perfect rings, Harada rings, and quasi-Frobenius rings.
Lifelong Learning - Signs, Discourses, Practices
This text explores the different ways in which the various social practices in which people participate becomes signed as learning, how and why that occurs and with what consequences. It takes seriously the linguistic turn in social theory to draw upon semiotics and poststructuralism through which to explore the significance of lifelong learning as an emerging discourse in education. The text explores the different ways in which learning conveys meaning and is given meaning. Given this, lifelong learning therefore is a way, and a significant way, in which learning is fashioned. The text then explores the notion that, if learning is lifelong and lifewide, what precisely is learning as distinct from other social practices and how those practices are given meaning as learning.
Life Conduct in Modern Times : Karl Jaspers and Psychoanalysis
This award-winning book investigates the critique of psychoanalysis formulated by the psychiatrist and philosopher Karl Jaspers (1883-1969) over a period of five decades. His arguments against Freud and his followers are examined from systematic perspectives. The study traces the medico-historical roots of Jasper’s criticism of psychoanalysis and then places it within the framework of scientific theory before devoting itself extensively to medico-ethical aspects of the controversy, which are ultimately treated in terms of a history of mentalities. According to this view, Jasper’s student Hannah Arendt saw to it that the philosopher be made aware of the socio-cultural impact which psychoanalysis was beginning to have in the U.S.A.
Liberal Democracy : Prosperity through Freedom
Aims to show which factors have been decisive in the rise of successful countries. Never before have so many people been so well off. However, prosperity is not a law of nature; it has to be worked for. A liberal economy stands at the forefront of this success – not as a political system, but as a set of economic rules promoting competition, which in turn leads to innovation, research and enormous productivity.
Levity of Design : Cambridge Scholars Publishing
How can poetry embrace morality through focusing on metaphrasts? What is the relation between an allummette and the alpha rhythm? Why is it that money has turned into a metonym of goodness and success? And above all, is it still possible to think of the human subject as a viable category in late modernity? These are some of the questions that J.
Levinas Concordance
The concrete impact of the Levinasian philosophy upon the variousdirections of thinking – from ontology and ethics to Jewish thought, theolo-gy, aesthetics or feminism – attests moreover the great significance of thissingular figure of our times.For more than three decades now his philosophy has come to be thesubject of many doctoral theses, articles and books. The complete “Levinasbibliography” counts currently thousands of titles in more than ten lan-guages. The important contribution that a Levinas Concordancewould bring asa valuable instrument for exegetes,
Les vérités du cancer : Partager l'information, installer la relation = The truths about cancer : Sharing information, building the relationship
Les médecins et les équipes soignantes perçoivent comme une nouvelle pression la nécessité de transmettre le diagnostic de cancer et de discuter des options thérapeutiques avec un patient qui n’est pas toujours prêt à s y confronter. Bien que l’on puisse saluer le partage de l’information et encourager la transparence, le médecin prend le risque du blocage de dialogue, d’une indifférence, au pire d’un traumatisme. L’idée d’une diminution d’un certain pouvoir médical s’insinue dans le « dispositif » d’annonce qui renvoie la clinique à des apprentissages techniques. Au contraire, certains médecins cherchent à s’inscrire dans un mouvement plus démocratique. Ils constatent que pour le malade, savoir n’est pas choisir, et que dans les cas difficiles, ils restent encore décideurs. Cet ouvrage fait le point sur les changements obtenus par les lois et leurs conséquences sur les pratiques et incite à une réflexion philosophique sur la vérité et les vérités des interlocuteurs de la scène médicale.
Les prothèses tricompartimentaires du genou de première intention : Techniques opératoires. Problèmes et solutions = Primary tricompartmental knee replacement : Surgical techniques, problems, and solutions
It seems difficult and presumptuous to want to write a book on total knee replacement. There are many quality works dealing with this subject. The knee prosthesis has, from its origin, particularly in the United States, given rise to considerable studies in all directions: biomechanical, physiological, biological and industrial. Our goal is to offer the youngest a book of simple knowledge without pretension of completeness or prejudice as to long debated subjects (conservation or not of the posterior cruciate ligament, cement or without cement, resurfacing or not of the patella, fixed plate or mobile platform, etc.), and to give practical advice based on our experience. Why limit yourself to first-line tricompartmentals? Because it is the most common solution to the usual degenerative knee problems. In addition, unicompartment and revision prostheses will be the subject of further literature. Everyone knows that to put a knee prosthesis model, and therefore to a system. However, it is important to be able to keep your freedom of analysis in order to maintain your freedom of choice. You have to know how to put on a knee prosthesis without compromise or fanaticism. Convictions are more dangerous enemies of truth than lies. Nietzsche
Les infections urinaires = Urinary tract infections
Les Infections urinaires provides an update on knowledge concerning the epidemiology of community-based infection, on the mechanisms of bacterial resistance and on certain aspects of the disease useful to urologists as well as infectious diseases, gynecologists, emergency physicians and attending physicians. . Nosocomial urinary tract infection is approached from the perspective of risk factors. Acute and chronic prostatitis was the subject of a consensus conference supported by the World Health Organization within the framework of the International Consensus Conferences in Urology in Paris. The full text and the recommendations are reported with the consent of their authors. This book is an author's book and not an author's book because urinary tract infection is multiple, complex and justifies a multidisciplinary approach.
Les douleurs abdominales en questions : Rôle physiopathologique de la sensibilité viscérale = Abdominal pain in question : The pathophysiological role of visceral sensitivity
The gut-brain axis refers to the network of nerve pathways that connect the myenteric plexus, the veritable "gut brain," to the central nervous system. Nearly 80% of these neurons are sensory neurons, and the afferent pathways that transmit information from the digestive tract to the central nervous system play a crucial role in the physiological regulation of digestive functions, as well as in certain pathological conditions. A large majority of these sensations remain unconscious and give rise to reflex responses. Only those requiring a conscious response reach the level of awareness in a normal state (hunger, thirst, the urge to defecate). In pathological situations, the same is true for painful sensations of digestive origin. Functional bowel disorders are a frequent reason for consultation. Their pathophysiology is now based on a model integrating the various etiological factors around the brain-gut axis. These patients frequently present with visceral hypersensitivity, which manifests as an increased perception of digestive sensations, notably the onset of pain in response to stimuli that are not painful in normal subjects. Recognizing the role of visceral hypersensitivity has made it possible to explain the mechanism of action of medications used to treat functional bowel disorders and paves the way for the development of new molecules acting on digestive afferents. In this book, we will describe the anatomical and physiological basis for understanding the concept of visceral sensitivity and the role of digestive afferents in the pathophysiology of acute and chronic abdominal pain, particularly irritable bowel syndrome.
Leptin
The discovery of leptin little more than a decade ago, as a hormone produced in white adipose tissue with an important role in satiety and energy expenditure, was a seminal event in our understanding of adiposity. This initial advance in the new endocrinology of obesity was soon followed by the realization that leptin was not only produced in adipose tissue, but in many different tissues of the body, and that receptors were similarly distributed. Additionally, the early recognition of infertility that was associated with leptin deficiency prompted research that identified roles for the polypeptide in virtually every area of reproductive biology.
Leibnizs Metaphysics of Time and Space
Leibniz’s metaphysics of space and time stands at the centre of his philosophy and is one of the high-water marks in the history of the philosophy of science. In this work, Futch provides the first systematic and comprehensive examination of Leibniz’s thought on this subject. In addition to elucidating the nature of Leibniz’s relationalism, the book fills a lacuna in existing scholarship by examining his views on the topological structure of space and time, including the unity and unboundedness of space and time. It is shown that, like many of his more recent counterparts, Leibniz adopts a causal theory of time where temporal facts are grounded on causal facts, and that his approach to time represents a precursor to non-tensed theories of time.
Leibniz and the natural world : Activity, passivity and corporeal substances in Leibniz's Philosophy
In the present book, Pauline Phemister argues against traditional Anglo-American interpretations of Leibniz as an idealist who conceives ultimate reality as a plurality of mind-like immaterial beings and for whom physical bodies are ultimately unreal and our perceptions of them illusory. Re-reading the texts without the prior assumption of idealism allows the more material aspects of Leibniz's metaphysics to emerge. Leibniz is found to advance a synthesis of idealism and materialism. His ontology posits indivisible, living, animal-like corporeal substances as the real metaphysical constituents of the universe; his epistemology combines sense-experience and reason; and his ethics fuses confused perceptions and insensible appetites with distinct perceptions and rational choice. In the light of his sustained commitment to the reality of bodies, Phemister re-examines his dynamics, the doctrine of pre-established harmony and his views on freedom.
Leibniz : What Kind of Rationalist?
The chapters of the book are the result of intense discussion in the course of an international conference focused on the title question of this book, and were selected in view of their contribution to this topic. They are clustered in thematically organized parts. No effort has been made to hide the controversies underlying the different interpretations of Leibniz’s “rationalism” – in each particular domain and as a whole. On the contrary, the editor firmly believes that only through a variety of conflicting interpretive perspectives can the multi-faceted nature of an oeuvre of such a magnitude and variety as Leibniz’s be brought to light and understood as it deserves.
Lehninger Principles of Biochemistry
Help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry.
Legitimacy Needs as Drivers of Business Exit
A diversified firm’s withdrawal from a business unit, i.e. business exit, is a significant phenomenon in management practice. Although divestitures are highly relevant in practice, the acquisition of business units attracts much more attention in strategic management research. Carolin Decker develops and empirically applies a framework in which business exits serve the purpose of re-establishing a firm’s previously harmed legitimacy. She suggests four types of legitimacy needs that are to be satisfied with the divestiture of a business unit and the simultaneous pursuit of strategic reorientation. The author tests the theoretical framework with secondary data on 213 business exits. Her findings support the idea that legitimacy needs drive the likelihood of fit-enhancing business exits in divesting firms.
Lectures on the Automorphism Groups of Kobayashi-Hyperbolic Manifolds
Presents a coherent exposition of recent results on complete characterization of Kobayashi-hyperbolic manifolds with high-dimensional groups of holomorphic automorphisms. These classification results can be viewed as complex-geometric analogues of those known for Riemannian manifolds with high-dimensional isotropy groups, that were extensively studied in the 1950s-70s. The common feature of the Kobayashi-hyperbolic and Riemannian cases is the properness of the actions of the holomorphic automorphism group and the isometry group on respective manifolds.
Lectures on Symplectic Geometry
Provides a fast introduction to symplectic geometry for graduate students with some knowledge of differential geometry, de Rham theory and classical Lie groups. This text addresses symplectomorphisms, local forms, contact manifolds, compatible almost complex structures, Kaehler manifolds, hamiltonian mechanics, moment maps, symplectic reduction and symplectic toric manifolds. It contains guided problems, called homework, designed to complement the exposition or extend the reader's understanding.
