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Biomarkers for alzheimer’s disease drug development
Aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer’s disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer’s disease, cutting-edge developments in neuropathology and their relevance for Alzheimer’s disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Biomarkers as targeted herbal drug discovery : A pharmacological approach to nanomedicines
Looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid. Reviews the literature on inflammatory biomarkers in the treatment of diseases Looks at the development of herbal drug discovery based on biomarkers Explores emerging concepts of nanomedicines for herbal drug delivery Takes an interdisciplinary approach, with application to disciplines related to medical, pharmaceutical, biotechnological, Ayurvedic, Unani and biomedical engineering fields
Biologics, biosimilars, and biobetters : An introduction for pharmacists, physicians and other health practitioners
Explains what pharmacists need to discuss the equivalence, efficacy, safety, and risks of biosimilars with physicians, health practitioners, and patients about Guides regulators on pragmatic approaches to dealing with these drugs in the context of rapidly evolving scientific and clinical evidence Balances scientific information on complex drugs with practical information, such as a checklist for pharmacists
Biologics in General Medicine
The idea for this book was born during the symposium on biologics organized by ZAFES (Center for Drug Research, Development and Safety at the University of Frankfurt am Main) in September 2005. Highly distinguished researchers special- ing in the field of biologics had gathered together to exchange information on this relatively new subject. Realizing that this symposium was one of the few sources of condensed information on biologics, it became obvious that we had to create a means of informing an interested wider circle of scientists and especially general c- nicians. Therefore, the editors of this book suggested to the researchers at the symposium andalsotoprominent scientists andcliniciansinvolvedinthe developmentand application of biologics as their major field of interest the idea of assembling this compendium. We received an overwhelmingly positive response – thankfully also from the publisher – most being more than willing to support this innovative project with highly relevant chapters on the latest state of the art.
Bioinformatics tools for pharmaceutical drug product development
Presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. And include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall.
Bioinformatics drug discovery
Quantitative tools are becoming increasingly important in order to understand complex cascade of signal transduction events, pathways or biochemical reactions. The book showcases how computational techniques and algorithms are applied to biological data analysis, interpretation, and modelling. It covers applications in drug design and discovery, immune systems, phylogenetic analysis and protein structures.
Bioelectromagnetics current concepts : The mechanisms of the biological effect of extremely high power pulses
Proceedings of the NATO Advanced Research Workshop on The Mechanisms of the Biological Effect on Extra High Power Pulses (EHPP), Yerevan, Armenia 3 - 5 March 2005
Bioanalytical aspects in biological therapeutics
The book discusses the challenges and considerations for bioanalytical support, covering a wide range of central topics in the field, including overview and basic immunology for testing of biological therapeutics, pharmacokinetic aspects, clinical immunogenicity prediction and testing, biomarker testing, biotransformation assessment for biologics, statistical aspects of bioanalytical testing, regulatory expectations, and more
Bioactives and pharmacology of medicinal plants : Vol.1
Bioctives and Pharmacology of Medicinal Plants, concisely presents an abundance of important information on the bioactive and pharmacological properties of medicinal plants. It provides valuable comprehensive research and studies on bioactive phytocompounds of over 68 important medicinal plants with beneficial properties. For each species included in the volume, a brief introduction is given along with their bioactive compounds and chemical structures, followed by their chief pharmacological activities that include antiviral, antimicrobial, antioxidant, anti-cancer, anti-inflammatory, antidiabetic, hepatoprotective, nephroprotective, and cardioprotective activities. A review of the published literature on pharmacological activities on each species is included also, providing a thorough resource on each of the plants covered in the volume.
Bioactives and pharmacology of Legumes
A variety of bioactives and therapeutics from the legume family (Fabaceae or Leguminosae) are thoroughly detailed. For each species included in the volume, a brief introduction is given, the plant’s bioactive compounds are listed, and its chemical structures shown, followed by their pharmacological activities. Many of these plants have medicinal activities that include antiviral, antimicrobial, antioxidant, anticancer, anti-inflammatory, and antidiabetic, hepatoprotective, nephroprotective and cardioprotective. The biochemical characteristics of the 37 plants included, such as the type of starch, protein, and fibers, can be exploited as binders, excipients, thickeners, and dispersants in the formulation of various products in the pharmaceutical industry. The published literature on the pharmacological activities on each species is reviewed and presented in a concise and clear manner.
Bioactives and pharmacology of lamiaceae
Provides a wealth of information on plants in the Lamiaceae family, noted for their essential oils and bioactives and pharmacological properties. The chapters investigate a wide variety of species, providing for each an introduction, characteristics, properties, distribution, traditional uses, and current and potential pharmacological applications. Aiming to be a resource for the development of new drugs based on species within the Lamiaceae family, the volume discusses 26 species, including bungleweed (Ajuga), Malabar catmint (Anisomeles malabarica), beechwood (Gmelina arborea), Brazilian mint (Hyptis crenata), rosemary (Rosmarinus officinalis L.), holy basil (Ocimum tenuiflorum), and many more.
Bioactive egg compounds
Hen eggs have exceptional potential as an inexhaustible source for a variety of products with unique properties. These products are valuable to human health and nutrition and can be used as raw materials for diverse purposes in the cosmetics and pharmaceutical industries. Bioactive Egg Compounds presents the latest results and concepts in the biotechnological use of egg compounds. Following an introduction to the different compounds of egg white, yolk and shell, the nutritive value of egg compounds is discussed. Procedures for processing egg compounds to improve their nutritive value are described, including the concept of so-called enriched eggs. Also described is the isolation and application of egg compounds with special properties, such as antibiotic action.
Beyond global food supply chains : Crisis, disruption, regeneration
Through a set of incisive essays, this incredibly timely book shows how much the COVID-19 pandemic has exposed both vulnerabilities and opportunities - for (racial) capitalism and its discontents alike to intervene in food supply chains. A most welcome publication! This book takes the upheaval of the global COVID-19 pandemic as a springboard from which to interrogate a larger set of structural, environmental and political fault lines running through the global food system. In a context in which disruptions to the production, distribution, and consumption of food are figured as exceptions to the smooth, just-in-time efficiencies of global supply chains, these essays reveal the global food system as one that is inherently disruptive of human lives and flourishing, and of relationships between people, places, and environments. The pandemic thus represents a particular, acute moment of disruption, offering a lens on a deeper, longer set of systemic processes, and shining new light on transformational possibilities.
Behavioral pharmacology of the cholinergic system
The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.
Bee products and their applications in the food and pharmaceutical industries ; 1st ed.
Focuses on the health benefits of selected bee products by looking more closely at their pharmacological potentials and therapeutic applications in coping with various diseases. The book explores some of these products, such as royal jelly, propolis and bee venom, which is highly attractive to the food supplement sector due to the biological actions that are proved by scientific studies. Bee products also attract the cosmetics industry by utilizing those products in various applications such as hair products, toothpaste, sunscreen creams, lip balsams, or facial moisturizing creams. Each chapter focuses on a particular health benefit, providing more compact and detailed information about each activity for a specific interest. The mainframe of the book is based on the medicinal and pharmacological functions of bee products, with the therapeutic applications for each bee product supporting the mechanism of action of their biological functions.
Bee products : Chemical and biological properties
Presents an updated discussion on the chemical composition and biological properties of the main bee products, which until now have been presented separately in different editions This book scoops out studies about bee products most used in marketing and in traditional medicine such as honey, royal jelly, propolis, bee pollen and bee venom Discusses chemical composition and biological function of the different bee products on topics such as nutrition, aging and age-related diseases, cancer, neurodegenerative diseases and pathogen infections Bee products are rich in several essential nutrients and non essential nutrients, as sugars, minerals, proteins, free amino acids, vitamins, enzymes and polyphenols, that seem to be closely related to their biological functions. The effects of these products in nutrition, aging and age-related diseases, cancer, neurodegenerative diseases and pathogen infections are discussed.
Basiswissen pharmakologie = Basic knowledge of pharmacology
Offers a clear and concise overview of all exam-relevant pharmacology content. It guides you through the entire foundational knowledge, from the basics to the most important clinical pictures, in an easily understandable way and aligned with the German National Competency-Based Learning Objectives for Medicine (GK) and National Competency-Based Learning Objectives for Medicine (NKLM). Benefit from the lecturer's many years of experience, who has carefully selected and presented the essential information for you.
Basic principles of drug discovery and development ; 2nd ed.
Presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields.
Basic pharmacokinetics
Introduces basic pharmacokinetic concepts to beginner learners to help them understand the absorption, distribution, metabolism, and excretion of drugs. Accompanying the book is a website with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.
Basic knowledge of pharmacology
Concise and up-to-date coverage of the most important drugs Integration of experimental and clinical pharmacology with focus on diseases Discusses the most important drugs (400) in the context of relevant diseases. Summary tables and schemes, MCQ exam questions, case studies and a list of drugs aid memorization of the material before an exam. All chapters are written in the same concise style and use a modern and precise pharmacological nomenclature. After reading of the book, the student will be able to critically assess the proper use of the most important drugs and advise patients properly. The didactic concept of the book has been developed on the author’s own pharmacology courses for which he has received numerous teaching awards. The book takes advantage of the learning spiral, in which material is presented repeatedly from various angles.
