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Human Challenge Studies in Endemic Settings : Ethical and Regulatory Issues
This book provides an extensive review of ethical and regulatory issues related to human infection challenge studies, with a particular focus on the expansion of this type of research into endemic settings and/or low- and middle-income countries (LMICs). Human challenge studies (HCS) involve the intentional infection of research participants, and this type of research is rapidly increasing in frequency worldwide
Human Cell Culture ; Vol. VI : Embryonic Stem Cells
If you wish to grow or characterize embryonic stem cells or persuade them to differentiate into a particular cell type, then this book contains information that is vital to your success. The aim is to provide clear simple instructions and protocols for growing, maintaining and characterizing embryonic stem cells and details of the various methods used to make stem cells differentiate into specific cell types.
Hugo and Russell's pharmaceutical microbiology
Microbiology is one of the essential pharmaceutical sciences upon which the study and practice of pharmacy is built. It has a bearing on all aspects of the manufacture of medicines and sterile products, from their design and development to their delivery as quality products. Few interventions are more central to modern medicine than the treatment of infection, where antibiosis, vaccination and hygienic practices have essential roles to play. The COVID-19 pandemic, the appearance of new pathogens and the rise of antibiotic resistance have demonstrated most completely the need for pharmaceutical practitioners, researchers and industrial scientists to be fully conversant with this field. The 9th edition of Hugo and Russell’s Pharmaceutical Microbiology has been updated to meet this need. Having long served as the sole comprehensive textbook covering this subject, it has now been adapted to a critical new period in the advancement of medical and pharmaceutical research and development. Its experienced editors have incorporated contributions from subject experts and created a text which will serve the next generation of pharmacy students, pharmaceutical industry scientists and researchers.
Hox Gene Expression
The study of Hox genes is crucial not only in exploring the enigma of homeosis but also in understanding normal development at the fundamental molecular level. "Hox Gene Expression" starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. It deals with homeotic genes- their evolution, structure, normal and abnormal function. Researchers and graduate students in Biology and Medicine will benefit from this integrated overview of Hox gene activities.
How to Improve the Results of Peripheral Nerve Surgery
All over the world research is going on to improve the outcome of the treatment of peripheral nerve lesions. Questions over questions arise. Is the autologeous nerve grafting still the golden standard in bridging defects? Have alternative techniques to overcome defects reached a level to replace autografting? To which length are they effective? What is the role of allografting? Are there still indications for vascularized nerve grafts? What can be expected from end to side coaptation? Does it exist at all? Under what conditions useful recoveries can be achieved? Are there new developments in physical medicine and physiotherapy? Can the quality of recovery be influenced by surgery on muscles to provide a better equilibrium of forces? To what extent cerebral plasticity may be exploited to improve functional results? The contributions in this book give answers to all of these questions.
How to engineer software : A model-based approach
The book promotes development scalability through domain partitioning and subdomain partitioning. It also explores software documentation that specifically and intentionally adds value for development and maintenance. Contains many illustrative examples of model-based software engineering, from semantic model all the way to executable code Explains how to derive verification (acceptance) test cases from a semantic model Describes project estimation, along with alternative software development and maintenance processes Shows how to develop and maintain cost-effective software that solves real-world problems
How Apollo flew to the moon
Out of the technological battlefield of World War II came a team of gifted German engineers and designers who developed the vengeance weapon, the V-2, which evolved into the peaceful, powerful Saturn V rocket to take men to the Moon. David Woods tells the exciting story, starting from America’s post war astronautical research facilities, that used the V-2 for the development of the robust, resilient and reliable Saturn V launcher. He describes the initial launches through manned orbital spaceflights, comprehensively detailing each step, including computer configuration, the role of ground control, trajectory planning, lunar orbiting, separation of the lander, walking and working on the Moon, retrieval of the lunar astronauts and returning to Earth in this massive technical accomplishment.
Housing Market Dynamics in Africa
Utilizes new data to thoroughly analyze the main factors currently shaping the African housing market. Some of these factors include the supply and demand for housing finance, land tenure security issues, construction cost conundrum, infrastructure provision, and low-cost housing alternatives. Through detailed analysis, the authors investigate the political economy surrounding the continent’s housing market and the constraints that behind-the-scenes policy makers need to address in their attempts to provide affordable housing for the majority in need. With Africa’s urban population growing rapidly, this study highlights how broad demographic shifts and rapid urbanization are placing enormous pressure on the limited infrastructure in many cities and stretching the economic and social fabric of municipalities to their breaking point. But beyond providing a snapshot of the present conditions of the African housing market, the book offers recommendations and actionable measures for policy makers and other stakeholders on how best to provide affordable housing and alleviate Africa’s housing deficit.
Housing Contemporary Ireland : Policy, Society and Shelter
This book, the first comprehensive review of housing in Ireland for many years, introduces, in an accessible manner, the key housing developments since the foundation of the State and also reports on the findings of the latest research on the transformation of the sector in the past decade. The issues examined here include: -the impact of the house price boom on wealth and affordability / -the urban renewal schemes and private rented housing -the management of social housing / -the accommodation of Travellers and homeless people -rural housing policy and politics
Hot Property : The Housing Market in Major Cities
This book discusses booming housing markets in cities around the globe, and the resulting challenges for policymakers and central banks. Cities are booming everywhere, leading to a growing demand for urban housing. In many cities this demand is out-pacing supply, which causes house prices to soar and increases the pressure on rental markets. These developments are posing major challenges for policymakers, central banks and other authorities responsible for ensuring financial stability, and economic well-being in general. This volume collects views from high-level policymakers and researchers, providing essential insights into these challenges, their impact on society, the economy and financial stability, and possible policy responses. The respective chapters address issues such as the popularity of cities, the question of a credit-fueled housing bubble, the role of housing supply frictions and potential policy solutions. Given its scope, the book offers a revealing read and valuable guide for everyone involved in practical policymaking for housing markets, mortgage credit and financial stability.
Hot cracking phenomena in welds
The first chapter provides an overview of the various hot cracking phenomena. Different mechanisms of solidification cracking proposed in the past decades are summarized and new insight is particularly given into the mechanism of ductility dip cracking. The effects of different alloying elements on the hot cracking resistance of various materials are shown in the second chapter and, as a special metallurgical effect, the initiation of stress corrosion cracking at hot cracks has been highlighted. The third chapter outlines how numerical analyses and other modelling techniques can be utilized to describe hot cracking phenomena and how such results might contribute to the explanation of the mechanisms. Various hot cracking test procedures are presented in the final chapter with a special emphasis on standardization. For the engineering and natural scientists in research and development the book provides both, new insight and a comprehensive overview of hot cracking phenomena in welds. The contributions additionally give numerous individual solutions and helpful advice for international welding engineers to avoid hot cracking in practice. Furthermore, it represents a very helpful tool for upper level metallurgical and mechanical engineering students.
Hormones and the brain
Peripheral hormones have a major impact on the brain: they are able to interfere with its development, to affect release of neurotransmitters and concentrations of receptors, to trigger growth factors involved in lesion repair. These multiple actions account for their capacity to modulate a number of physiological parameters, from reproductive functions to memory, behaviour and aging. Depending upon intensity and duration of exposure, they can be either neuroprotective or neurotoxic, for instance by affecting production of free radicals. This book, based on contributions of pioneer investigators in the field, outlines the ambiguous actions of gonadal steroids (estradiol, progesterone, testosterone, inhibin and activin) and of neurosteroids, related moieties produced in the brain itself. After summarizing their multiple mechanisms of action, which involve both direct effects on neuronal membranes and activation of genes coding for specific proteins in neurons or glial cells, the book outlines the role of hormones in pathogenic processes such as mental disturbances or neurodegenerative diseases.
Hormonal carcinogenesis V
Information gathered from cell-free systems, cell cultures, animal models, and human studies, together will (1) provide important insights to our understanding of hormonal cancer causation, development, and prevention; (2) be the primary objective of these Symposia.
Homo Oeconomicus : The Economic Model of Behaviour and Its Applications in Economics and Other Social Sciences
The economic model of behaviour is fundamental not only in economic theory, but also in modern approaches of other social sciences, above all in political science and law. This book provides a comprehensive treatise of the general model, its philosophical and methodological foundations and its applications in different fields. In addition to the basic model, extensions to its assumptions are examined to account for complex applications like low-cost situations with moral behaviour. Finally, the book takes a broader perspective by evaluating the impact of the model on economic policy and on the development of the field of social science as a whole, such as the competition between individualistic and collectivist approaches.
Holonic and multi-agent systems for manufacturing ; 2nd International conference on industrial applications of holonic and multi-agent systems, HoloMAS 2005, Copenhagen, Denmark, August 22-24, 2005, Proceedings
The challenge faced in today’s manufacturing and business environments is the question of how to satisfy increasingly stringent customer requirements while managing growing system complexity. For example, customers expect high-quality, customizable, low-cost products that can be delivered quickly. The systems that deliver these expectations are by nature distributed, concurrent, and stochastic, and, as a result, increasingly difficult to manage. Unfortunately, the traditional hierarchical, strictly centralized approach to control used in these domains is characteristically inflexible, fragile, and difficult to maintain. These shortcomings have led to the development of a new class of manufacturing and supply-chain decision-making approaches in recent years. Solutions based on these approaches usually explore a set of highly distributed decision-making units that are capable of autonomous operations while cooperating interactively to resolve larger problems. The units, referred to as agents in classical computer science and software engineering, or holons if physically integrated with the manufacturing hardware, interact by exchanging information. These units are motivated by arriving at local solutions as well as collaborating and sharing resources and goals in solving the overall problem in question collectively.
Holocaust Survivors and Immigrants : Late Life Adaptations
Based on a unique research study, this volume examines the later life development of Holocaust survivors from Israel and the U.S. Through systematic interviews, the authors -- noted researchers and clinicians -- collected data about the lives of these survivors and how they compared to peers who did not share this experience. The orientation of the book synthesizes several conceptual approaches â€" gerontological and life span development, stress research, and traumatology, and also reflects the varied disciplines of the authors, spanning psychology, social work, and sociology
History of the European Association for Haematopathology
Offers a personal overview on the history of the European Association for Haematopathology. This book also traces the development of haematopathology. It is of interest to residents and researchers in Pathology and Hematopathology.
History of Semiconductor Engineering
In this book, the author argues that the group of inventors was much larger. This richly illustrated account is a personal recollection of the development of integrated circuits and personalities – such as Russell Ohl, Karl Lark-Horovitz, William Shockley, Carl Frosch, Lincoln Derick, Calvin Fuller, Kurt Lehovec. Jean Hoerni, Sheldon Roberts, Jay Last, Isy Haas, Bob Norman, Dave Allison, Jim Nall, Tom Longo, Bob Widlar, Dave Talbert, Frank Wanlass, and Federico Faggin. Here is the first comprehensive behind-the-scenes account of the history of the integrated circuit, the microelectronics industry, and the people closely involved in the development of the transistor and the integrated circuit.
History of Nordic computing ; IFIP WG9.7 ; 1st Working conference on the history of Nordic computing (HiNC1), June 16-18, 2003, Trondheim, Norway
The IFIP series publishes state-of-the-art results in the sciences and technologies of information and communication. The scope of the series includes: foundations of computer science; software theory and practice; education; computer applications in technology; communication systems; systems modeling and optimization; information systems; computers and society; computer systems technology; security and protection in information processing systems; artificial intelligence; and human-computer interaction. Proceedings and post-proceedings of referred international conferences in computer science and interdisciplinary fields are featured. These results often precede journal publication and represent the most current research. The principal aim of the IFIP series is to encourage education and the dissemination and exchange of information about all aspects of computing.
History of Banach Spaces and Linear Operators
Written by a distinguished specialist in functional analysis, this book presents a comprehensive treatment of the history of Banach spaces and (abstract bounded) linear operators. While other historical texts on the subject focus on developments before 1950, this one is mainly devoted to the second half of the 20th century.Banach space theory is presented in a broad mathematical context, using tools from such areas as set theory, topology, algebra, combinatorics, probability theory, and logic.
