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Magnetic Resonance of Myelination and Myelin Disorders
The book has been extensively revised and expanded to do justice to the rapid advances in MR technology, molecular biochemistry, and genetics and the discovery of new disease entities with prominent white matter involvement. Forty chapters have been added, and the number of illustrations has risen considerably. The ability to confirm the presence of genetic alterations in a number of disorders allows more advantageous presentation of the phenotypic variation as expressed in differ.
Magnetic Resonance Imaging in Orthopedic Sports Medicine
Though magnetic resonance imaging has helped revolutionize the field of orthopedic medicine, a difference in perspective persists between radiology and orthopedic specialists. Magnetic Resonance Imaging in Orthopedic Sports Medicine is an interdisciplinary resource designed to bridge this gap.
Magnetic Resonance Imaging in Ischemic Stroke
The imaging of stroke has undergone significant changes owing to the rapid progress in imaging technology. This volume, comprising three parts, is designed to provide a comprehensive summary of the current role of MR imaging in patients with ischemic stroke. The first part outlines the clinical presentations of stroke and discusses the diagnostic efficacy and therapeutic impact of MR imaging. The second and third parts form the core of the volume, and are based on a novel approach in that the topic is presented from two very different viewpoints. Part 2 provides a detailed presentation of the distinguishing features of stroke from the radiologist's perspective. By contrast, part 3 addresses the needs of the clinician, documenting specific stroke syndromes and their correlates on MR imaging. The overall aim has been to create a well-illustrated volume with broad appeal that links pathology, radiology and stroke medicine in an informative manner.
Magnetic resonance angiography : techniques, indications and practical applications
The advent of contrast-enhanced MRA in the early to mid 1990s revolutionized the clinical approach to vascular imaging: an accurate non-invasive imaging modality, not requiring ionizing radiation or potentially nephrotoxic iodinated contrast media, was able to compete with the more hazardous and invasive catheter angiography. Today, MRA is a safe, easy-to-perform procedure routinely used in most imaging centers, and the continued development of faster, more powerful magnets and more effective contrast agents is increasingly helping to overcome many of the early limitations of the technique.
Macular Degeneration
Macular Degeneration: Science and Medicine in Practice provides a unique overview of current thinking in the pathogenesis, incidence and treatment of AMD. It includes, for the first time, a synthesis of the views of the world's leading scientists and practitioners regarding retinal biology, basic mechanisms, clinical and pathogenetic processes, and rational approaches to intervention.
Macrosocial Determinants of Population Health
Macrosocial Determinants of Population Health explores social factors such as culture, mass media, political systems, and migration that influence population health while systematically considering how we may best study these factors and use our knowledge from this study to guide public health interventions.Each section ends with Galea’s integrative chapters, bringing the observations and conclusions from the chapters into clear, usable focus. Macrosocial Determinants of Population Health is a work of major theoretical, empirical, and practical interest for disciplines as varied as public health, epidemiology, health promotion, sociology, and health policy. Its systematic field-building approach makes it as valuable to the public health provider as to the scholars and students studying the health of populations.
Lysosomes
This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases.
Lysosomal Storage Disorders
This book is dedicated to patients affected by Lysosomal Storage Disorders, and especially to the National Gaucher Foundation (USA) and the Colombian Association of Patients with Lysosomal Storage Diseases (ACOPEL for its Spanish Acronym). Both organizations will share in the sales of this book.
Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Lymphocyte Signal Transduction
Signal transduction through leukocyte receptors involves a variety of signaling molecules including kinases, phosphatases, adaptor proteins, small GTPases GTP exchange factors, membrane phospholipids as well as others. These signal transducers, regulated by inter- and intra-molecular interactions, as well as by various post-translational modifications, lead to the activation of transcription factors that mediate cellular differentiation and growth, effector cell functions, and apoptotic cell death. Several investigators from various parts of the world convened at the 3rd Lymphocyte Signal Transduction Workshop in Crete, Greece from May 27 to June 1, 2005 to discuss their most recent findings in leukocyte signaling. This volume represents a collection of topics discussed during the conference.
Lung Pathology
Learning the diagnostic elements of lung pathology requires not only great familiarity with a wide diversity of cases, but also a sharp eye for analyzing pictorial images. In Lung Pathology: A Consultative Atlas, leading experts offer a novel and substantive approach to the teaching of pulmonary pathology. Drawing on 263 challenging, yet exemplary, referral cases taken from files collected over 20 years by internationally renowned lung pathologist, Dr. Eugene Mark, the authors introduce his state-of-the-art approach to the interpretation of pulmonary pathology. This text includes the primary and/or differential diagnosis and the pertinent histological features of each case, as well as clinical history, when available. Key words or phrases in the text are highlighted and digitally hyperlinked to associated images or regions of interest within those images to assist the readers in their correlation. Novel and user friendly, Lung Pathology: A Consultative Atlas describes a cutting-edge diagnostic approach to pulmonary pathology, describing its principles and demonstrating its application in text and full-color illustrations drawn from 263 difficult cases of human lung pathologies.
Low-Dose Radiation Effects on Animals and Ecosystems : Long-Term Study on the Fukushima Nuclear Accident
Brings together the works of radiation biologists and ecologists to provide reliable radioecology data and gives insight into future radioprotection. The book examines the environmental pollution and radiation exposure, and contains valuable data from abandoned livestock in the ex-evacuation zone and from wild animals including invertebrates and vertebrates, aqueous and terrestrial animals, and plants that are subjected to long-term exposure in the area still affected by radiation. It also analyzes dose evaluation, and offers new perspectives gained from the accident, as well as an overview for future studies to promote radioprotection of humans and the ecosystem.
Long-Term Ecosystem Changes in Riparian Forests
Presents and analyzes the results of more than 30 years of long-term ecological research in riparian forest ecosystems with the aim of casting light on changes in the dynamics of riparian forests over time.
Longevity and Frailty
Contained in this book are the outcome of a colloquium sponsored by Fondation IPSEN in which interdisciplinary perspectives were brought to bear on conceptual, empirical and clinical aspects of this relationship. The result is a unique, innovative and timely blend of papers on topics ranging from frailty concepts in animal models and early Homo sapiens, to documentation of progress in morbidity compression, on the relationships between frailty and impairments and inflammation, and perspectives on long-term health care needs in an aging world.
Living with Heart Disease
The media are full of terms like angina, heart failure, coronary artery disease, thrombosis, but what do these mean to you? Gerry Coghlan and Clive Handler are experienced heart doctors who have written this book for people who have or might get coronary heart disease.
Living Rivers : Trends and Challenges in Science and Management
All over the world, sustainable river basin management is a leading principle of policy plans and legal instruments for water management (e.g. the European Water Framework Directive). The evidence, however, to underpin the full scope of sustainability is rather scanty. In this book an integrative perspective on trends and challenges in river science and management is demonstrated. The three pillars underneath sustainable water management, ecology, economy and sociology, are elaborated by experts in their fields. A number of papers integrate the current knowledge on the structure, functioning and management of ‘living rivers’. The book includes data and experiences concerning the rivers Allier, Meuse, Rhine, Sava and Tagliamento in Europe and the river Illinois in the USA. Sustainable river basin management asks for un-orthodox rehabilitation programmes and ecosystem based and transboundary management approaches.
Liver Radioembolization with Y90 Microspheres
Provides an in-depth account of all aspects of radioembolization, a relatively novel technique based on the efficacy of radiotherapy for the treatment of liver tumors.
Liver MRI : Correlation with other Imaging Modalities and Histopathology
In this seminal manuscript the - thor described a new imaging technique which moved the single dimension of NMR spectroscopy to the dual dimension of spatial orientation, thereby resulting in the foundation of modern magnetic re- nance (MR) imaging. Over the ensuing years, MR imaging has assumed an increasingly important role in clinical imaging. It distinguishes itself from other imaging modalities, such as ultrasound (US) or computed tomography (CT), by the unique ability to visualize specific tissue components in a non-- vasive manner. In the earlier days, diagnostic MR imaging was limited to cerebral and musculoskeletal diseases. - aging of other areas which are more prone to movement through breathing (abdominal) or pulsation motions (cardiac) became available more recently, with the introduction of faster sequences and the - velopment of more dedicated MR imaging coils.
Liver Immunology : Principles and Practice
parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation in an easy-to-read and thorough format. Authors also address the key issues that have arisen in this field in recent years, including physiological roles of hepatocytes, sinusoidal lining cells, activated macrophages (Kupffer cells), cholangiocytes and stellate cells, and their modulation of T cells, natural killer (NK) cells and NKT cells.
Liver carcinogenesis : Methods and protocols
Discusses the latest advancements in modern methodologies used to study liver carcinogenesis. The first half of this book describes pertinent preclinical models of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), established either through orthotopic induction of ectopic implantation. The second half of this book covers a diverse array of techniques applied to characterize the biochemical and cellular composition of hepatic malignancies that operate at the single-cell and histological levels. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
