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Antibiotic pharmacokinetic : Pharmacodynamic considerations in the critically Ill

Provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.

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Andrology for the Clinician

Andrology for the Clinician consists of two parts: In Part One, the busy clinician can easily find the problem-orientated information he or she needs on such issues as * Male factor fertility problems * Male contraception * Male genital tract infection and tumours Part Two contains in-depth subject-orientated information and adds important scientific background information to the recommendations received in Part One. Several leading experts have contributed to this work, which has been extensively subedited by world-renowned editors to ensure a well-structured didactic design and homogeneous content.

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Allergic Diseases : Diagnosis and Treatment

In this updated third edition of the critically-acclaimed volume, expert physicians assemble user-friendly, clinically-oriented guides to aid in the day-to-day management of the allergic patient. With an emphasis on common allergic diseases and the pharmacological tools to control them, Allergic Diseases: Diagnosis and Treatment, Third Edition disseminates the practical knowledge that practitioners have accumulated through practice and teaching in the field of allergy and immunology.

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AIDS-Associated Viral Oncogenesis

AIDS-associated viral oncology is a significant healthcare problem. Since the identification of human immunodeficiency virus (HIV)-associated acquired immune disease syndrome (AIDS), the role of viruses in human cancers has become acutely apparent over the past twenty years. The understanding and treatment of AIDS-associated cancers has become a major concern among healthcare organizations. Human cancers that were once rare in the population have now become common within the HIV infected population.

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Advances in Microbiology, Infectious Diseases and Public Health ; Vol.15

Focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention.

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Advanced Techniques in Diagnostic Microbiology

The book is divided into two sections. The first techniques section covers the principles and characteristics of techniques ranging from rapid antigen testing, to advanced antibody detection, to in vitro nucleic acid amplification techniques, and to nucleic acid microarray and mass spectrometry. Sufficient space is assigned to cover different nucleic acid amplification formats that are currently being used widely in the diagnostic microbiology field. Within each technique, examples are given regarding its application in the diagnostic field. Commercial product information, if available, is introduced with commentary in each chapt

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Abord clinique du malade âgé = Clinic Approach for the Elderly Patient

The general practitioner and the specialists are brought to examine a growing number of elderly or very old patients. Until now, they have hardly been prepared for this very special clinical approach where each symptom can relate to several causes, where the diseases are almost always multiple, symptomatic, or ready to reveal themselves by a complication, where a diagnosis can be. hide another, where a history - key to the diagnosis - may have been forgotten or concealed.

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A History of Limb Amputation

This book traces humanity’s long experience of natural amputations due to congenital absence, disease, frostbite, toxins, domestic and wild animal trauma, and for non-medical reasons related to punitive, ritual, and legal actions, ultimately leading to the development of elective surgical amputation. While the evolution of surgical techniques forms a major chapter in the book, many ancillary problems are addressed including the control of hemorrhage and infection, the approach to pain relief, the development of suitable instruments and equipment, and the invention of prostheses, all suitably illuminated with case histories and relevant illustrations. In addition, alternative procedures designed to avoid amputation, increasingly important in the last two centuries, are debated, and factors associated with self-amputation in extremis, not rare according to press reports, are also examined. A separate chapter considers the philosophy and interpretations of society, patients, and surgeons faced with amputation, particularly before anesthesia.

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A Closer Look at Antibiotic Resistance

Bacterial infections have become more difficult, and sometimes impossible, to treat due to antibiotic resistance, which occurs when bacteria develop the ability to defeat the available drugs designed to kill them. According to the Centers for Disease Control and Prevention, each year, 2 million Americans become sick with antibiotic-resistant infections, and of that, about 23,000 die. This book examines the challenges related to antibiotic resistance, the development and use of diagnostic testing to identify antibiotic resistance, the development of treatments for resistant infections, and appropriate antibiotic use.

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Lindhe's Clinical Periodontology and Implant Dentistry ; 2 Vol. Set ; 7th ed.

Provides an introduction to anatomy, including periodontal tissues, the edentulous ridge, the mucosa at teeth and implants, and osseointegration Discusses the epidemiology of periodontal and peri-implant diseases Explores the microbiology, including dental biofilms and calculus, periodontal infections, peri-implant infections, the pathogenesis of gingivitis and periodontitis, and the genetic susceptibility to periodontal disease Includes the latest perio- and peri-implant disease classifications Contains updated evidence-based preventive and treatment modalities for the treatment of periodontal and peri-implant diseases Features the latest evidence-based therapeutic alternatives on the use of dental implants to rehabilitate the lost dentition

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Lecture Notes on General Medicine for Dental Practice : A System based Approach with Dental Management Considerations

Offers a system based approach covering a broad range of topics in general medicine for dental practice. The book includes chapters on history taking and patient interview, general physical examination, system specific examination, common health related complaints, systemic infections, and diseases of the gastrointestinal, cardiovascular, respiratory, neurological, immunological, renal, endocrinal, dermatological and musculoskeletal systems. Nutritional disorders, psychiatric disorders, the female patient with menstrual, menopause and pregnancy related disorders, dental management of patients taking medications for systemic conditions and medical emergencies in dental practice have also been discussed in some detail.

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Lasers in Endodontics : Scientific Background and Clinical Applications

This book offers up-to-date information on all aspects of the use of lasers in endodontics, focusing especially on the various laser applications, including primary and permanent root canal therapies, retreatments, apical surgery and pulp therapy.

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Complications in Cranio-Maxillofacial and Oral Surgery

This superbly illustrated book equips readers with a detailed, up-to-date understanding of the surgical and nonsurgical complications that may arise during cranio-maxillofacial and oral surgery for a range of conditions, including malformations, infections, trauma, and tumors.

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Complex dental implant complications

This book offers up-to-date guidance in the diagnosis and management of the various complex complications that may be encountered during or after the placement of dental implants. The aim is to raise the awareness of clinicians regarding such complications and to equip them with the knowledge needed in order to deal with complications promptly and effectively.

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Common complications in endodontics : Prevention and management

Describes the most commonly encountered endodontic complications and provides up-to-date information on their prevention and management. The opening chapters explain the importance of accurate diagnosis and treatment planning, outline the role of digital radiography and CBCT in managing complications, and highlight the need for close attention to anatomic landmarks in order to avoid damage to neurovascular anatomy. Endodontic problems associated with different procedural errors are then discussed in detail, covering a wide variety of access- and instrumentation-related complications and the difficulties that may arise when using obturation techniques. Readers will also find information on the endodontic–periodontal relationship, special issues in geriatric patients, and the potential medical emergencies and precautions in specific patient subsets.

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Clinical oral medicine and pathology

The book has been well received internationally by a wide audience of clinicians, including general dentists, oral surgeons, otolaryngologists, primary care physicians, nurse practitioners, dental hygienists, physician assistants, and dermatologists, and sales have been strong among students and post-graduate residents training in medical, dental, and allied health fields, supporting the versatility of this work and serving as testimony to its value in both the academic and private practice arenas. Several key updates and improvements have been made to the second edition. All informational content has been updated to ensure accuracy and relevance, particularly in the rapidly evolving fields of oncology and pharmacology. A new chapter has been added entitled "Oral Sequelae of Cancer and Cancer Therapy" which better organizes and consolidates previous content while expanding on topics such as targeted therapies and hematopoietic stem cell transplantation. Additional clinical images have been included throughout the book so that the full clinical spectrum of any given condition is well-represented. Furthermore, the print quality, as well as the positioning and layout of the clinical images has been improved for optimal utility. Lastly, the summary boxes that follow each condition have been reconfigured with color-coded icons for improved definition, ease of use and cross-referencing.

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Anesthesia for oral and maxillofacial surgery

Reviews and describes anesthetic management of patients during oral and maxillofacial surgery. It covers applied anatomy of oral and maxillofacial surgery, difficult airway management and anesthetic techniques. The anesthetic management for patients with oral and maxillofacial disorders such as head and neck infection, head and neck injuries, and head and neck malignancy is also discussed. It will be a concise, up-to-date reference for specialists in anesthesiology, as well as practitioners in oral and maxillofacial surgery. It aims to share up-to-date knowledge and practical techniques with those who work in the fields related to oral and maxillofacial surgery.

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Mathematical Modeling of Biological Systems ; Vol. II : Epidemiology, Evolution and Ecology,Immunology, Neural Systems and the Brain, and Innovative Mathematical Methods

This two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout both works are mathematical and computational approaches to examine central problems in the life sciences, ranging from the organizational principles of individual cells to the dynamics of large populations.

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Mathematical Epidemiology

Based on lecture notes of two summer schools with a mixed audience from mathematical sciences, epidemiology and public health, this volume offers a comprehensive introduction to basic ideas and techniques in modeling infectious diseases, for the comparison of strategies to plan for an anticipated epidemic or pandemic, and to deal with a disease outbreak in real time. It covers detailed case studies for diseases including pandemic influenza, West Nile virus, and childhood diseases. Models for other diseases including Severe Acute Respiratory Syndrome, fox rabies, and sexually transmitted infections are included as applications. Its chapters are coherent and complementary independent units. In order to accustom students to look at the current literature and to experience different perspectives, no attempt has been made to achieve united writing style or unified notation.

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Malaria : Genetic and Evolutionary Aspects

This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane’s contribution from two directions: (a) it has been suggested that the “Malaria Hypothesis” was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004).

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