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Apoptosis, Senescence, and Cancer
Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers.this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment.
Anticancer activity in heterocyclic organic structures : A pathway to novel drug development : Part 1
New Directions in Organic & Biological Chemistry, explores the development of cancer therapeutics, focusing on molecular chemistry and advanced drug design approaches. Written by experts in theoretical chemistry and molecular chemistry, they bridge the gap between theoretical chemistry, molecular biology, and drug development. In Part I, they focus on the fundamental properties of heterocyclic compounds and innovative methodologies being employed to enhance therapeutic potential. By exploring various classes of heterocyclic compounds and diverse anticancer mechanisms.
Animals and the shaping of modern medicine : One health and its histories
This book breaks new ground by situating animals and their diseases at the very heart of modern medicine. In demonstrating their historical significance as subjects and shapers of medicine, it offers important insights into past animal lives, and reveals that what we think of as ‘human’ medicine was in fact deeply zoological.Each chapter analyses an important episode in which animals changed and were changed by medicine. Ranging across the animal inhabitants of Britain’s zoos, sick sheep on Scottish farms, unproductive livestock in developing countries, and the tapeworms of California and Beirut, they illuminate the multi-species dimensions of modern medicine and its rich historical connections with biology, zoology, agriculture and veterinary medicine. The modern movement for One Health – whose history is also analyzed – is therefore revealed as just the latest attempt to improve health by working across species and disciplines.
Angiogenesis and Direct Myocardial Revascularization
In Angiogenesis and Direct Myocardial Revascularization, an interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis.
Amino acid biosynthesis : Pathways, regulation and metabolic engineering
Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch. The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives.
Alternative Splicing and Disease
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
Algal Chemical Ecology
This is the first ever book devoted entirely to the chemical ecology of algae. Algae from both marine and freshwater habitats are covered, as are macroalgae (seaweeds) and microalgae (including phytoplankton). While its main emphasis is on the ecological rather than chemical aspects of the field, the book also includes a unique introductory chapter intended as a primer on algal natural products chemistry for ecologists. It elucidates the roles of chemical defenses in various regions and habitats, of DMSP, oxidative burst responses, and herbivore offense. Topics such as algal sensory chemical ecology and defenses against ultraviolet radiation are also treated, and an introduction to the chemical ecology of phytoplankton is provided.
Advances in Algal Biology : A Commemoration of the Work of Rex Lowe
Advances in Algal Biology: A Commemoration of the Work of Rex Lowe was written by students and colleagues of Rex Lowe to acknowledge his esteemed career that included exceptional contributions to research and teaching. Papers in the book cover a variety of topics in algal ecology, focusing on benthic algal ecology in freshwater ecosystems. The studies provide an unusual combination of small-scale experiments and large-scale regional surveys that bridge both basic and applied ecology. Ecologists, limnologists, phycologists, and environmental scientists will find valuable contributions to the development and application of algal research.
Advances and technical standards in neurosurgery : Vol. 32
This volume of Advances and Technical Standards in Neurosurgery covers some important new developments in functional neurosurgery and endovascular therapy. In the Technical Standards section a variety of topics are considered, including optic pathway gliomas, pineal lesions, cavernous sinus meningiomas, and the eternal problem of minor and repetitive head injury. Endovascular treatment of a variety of lesions is now common practice, and the state of the art in endovascular treatment for acute ischemic stroke is reviewed. An appraisal of the evidence on whether there is a place for microsurgical vascular decompression for essential hypertension raises interesting questions.
Adaptogens : Herbs for strength, stamina, and stress relief
Includes a Materia Medica with monographs covering 25 adaptogens, including eleuthero, ginseng, rhodiola, schisandra, ashwagandha, licorice, shatavari, reishi, and holy basil, as well as complementary nervines, restorative tonics, and nootropics Explains how adaptogens increase the body's resistance to adverse influences, increase energy and stamina, and counter the effects of age and stress on the body Details the actions, properties, preparation, and dosage for each herb and their uses in Ayurveda and Chinese medicine and as remedies for animals Every day our bodies strive to adapt and stay balanced, energized, and healthy, yet chronic stress and the resulting elevation of stress hormones such as cortisol have been shown to be major factors behind not only fatigue and weight gain but also many chronic and degenerative diseases
Acute Myelogenous Leukemia
The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation.
Acute coronary syndrome : Multidisciplinary and pathway-based approach
Acute coronary syndrome (ACS) affects millions of patients annually and requires immediate diagnosis and therapy. This practical algorithm-based handbook addresses the diagnosis and treatment of these patients and is designed for the medical personnel involved in the triage and management of ACS patients.
Abiotic Stress Tolerance in Plants : Toward the Improvement of Global Environment and Food
Stresses in plants caused by salt, drought, temperature, oxygen, and toxic compounds are the principal reason for reduction in crop yield. For example, high salinity in soils accounts for large decline in the yield of a wide variety of crops world over; ~1000 million ha of land is affected by soil salinity. Increased sunlight leads to the generation of reactive oxygen species, which damage the plant cells. The threat of global environment change makes it increasingly demanding to generate crop plants that could withstand such harsh conditions. Much progress has been made in the identification and characterization of the mechanisms that allow plants to tolerate abiotic stresses.
25 Years of P53 Research
Communication, awareness and access to information: Given the complexity of the field and the fact that data pertaining to each particular aspects of p53 biology or deregulation are scattered in many different publications, it is extremely difficult to access the full scale of relevant information of any specific p53-related topic. This book may help in this task by putting into perspective both general considerations on the p53 pathway and more specific information on various aspects of p53. In the longer term, however, open access to p53 complexity will require the development of knowledge bases accessible through the web and using simple navigation tools to guide users towards the specific information they need. Several efforts are currently being developed in that direction. They need to be strenghtened and better integrated within the rapidly growing galaxy of web-based information sources on molecular and individual variations in cancer. 2. Reference functional assays and structural analysis: Given the huge diversity of cellular and animal models for wild-type or mutant p53 functions, it will be important to set up standard, universally accepted assays to measure critical p53 protein functions.
A Platform-Centric Approach to System-on-Chip (SOC) Design
The book proposes a new methodology for realizing platform-centric design of complex systems, and presents a detailed plan for its implementation. The proposed plan allows component vendors, system integrators and product developers to collaborate effectively and efficiently to create complex products within budget and schedule constraints.
Management of deep carious lesions
Describes the challenges that deep carious lesions pose for dental practitioners, including the risk of endodontic complications and the difficulty of restorative treatment, and identifies options for overcoming these challenges on the basis of the best available evidence. The opening chapter sets the scene by discussing pathophysiology, histopathology, clinical symptomatology, and treatment thresholds. The various treatment options are then systematically presented and reviewed, covering non-selective, stepwise, and selective carious tissue removal and restoration, sealing of lesions using resin sealants or crowns, and non-restorative management approaches. In each case the current evidence with respect to the treatment is carefully evaluated. Advantages and disadvantages are explained and recommendations made on when to use the treatment in question. Illustrative clinical cases and treatment pathways for clinicians are included. This book will be of value for all practitioners who treat dental caries and carious lesions, whether in the permanent or the primary dentition. It will also be of interest to under- and postgraduate students in cariology and restorative, operative, preventive, and pediatric dentistry.
Learning the language of dentistry : disciplinary corpora in the teaching of English for specific academic purposes
Explores the affordances of disciplinary corpora for the teaching and learning of the language of dentistry, within the field of English for Specific Academic Purposes (ESAP). We extract disciplinary register features and vocabulary from three key genres of the dentistry discipline (published experimental research articles, case reports, and novice/professional research reports within the Dental Public Health domain), before integrating these features into ESAP pedagogy in the form of corpus-based ESAP materials that promote student-led direct engagement with disciplinary corpora – an approach known as 'data-driven learning'. This book is a timely and relevant addition to the field of corpus linguistics and ESAP, and is especially targeted at ESAP professionals who are required to teach disciplinary discourses but who may struggle to know what to teach as non-experts of the target discipline.
It’s all in your mouth biological dentistry and the surprising impact of oral health on whole body wellness
Pesents the principles of biological dentistry along with emerging scientific research on the mouth’s vital role in the body’s microbiome—a key to whole body wellness. Challenging conventional dental wisdom that views the teeth as separate from the rest of the body, and conventional dental practices that often cause more harm than good. Offers a necessary new approach to natural immunity to chronic disease and integrating dental hygiene into whole body health.
Artificial intelligence for oral health care : Applications and future prospects
Offers a deeper understanding of the foundational concepts of AI, its practical applications in oral health, and the possibilities that lie ahead. From oral pathology to maxillofacial surgery, prosthodontics to orthodontics, and endodontics to dental education, it presents compelling, evidence-based insights into how AI is changing the landscape of dentistry.
Advanced strategies for tooth extraction in dentistry : Beyond basics
Aims to provide comprehensive insights and techniques to dental students and practicing dentists seeking to expand their skills in tooth extraction. Building upon the foundational knowledge acquired during dental education, this book delves into the intricacies of advanced tooth extraction strategies. It covers a wide range of topics, including complex extractions, impacted teeth, surgical techniques, management of complications, and specialized cases.
