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Multi-Scale Approaches in Drug Discovery : From Empirical Knowledge to In silico Experiments and Back
Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents.
Multiple Sclerosis: Autoimmunity and Management
Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20–25 years in more than 30% of patients. The hallmark of MS is symptomatic episodes that occur months or years apart and affect different anatomic locations. Also, see the Autoimmune Disorders: Making Sense of Nonspecific Symptoms slideshow to help identify several diseases that can cause a variety of nonspecific symptoms. MS is diagnosed on the basis of clinical findings and supporting evidence from ancillary tests. Treatment consists of immunomodulatory therapy for the underlying immune disorder and management of symptoms, as well as nonpharmacologic treatments, such as physical and occupational therapy. Disease-modifying therapies have shown beneficial effects in patients with relapsing MS, including reduced frequency and severity of clinical attacks. These agents appear to slow the progression of disability and the reduce accumulation of lesions within the brain and spinal cord.
Multimodal Concepts for Integration of Cytotoxic Drugs
The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on different forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies, derived from recent advances in molecular oncology. The second part of the book comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented. In addition, the topics of acute and late toxicity, supportive treatment and tolerance in elderly patients are reviewed.
Multifunctional systems for combined delivery, biosensing and diagnostics
Multifunctional Systems for Combined Delivery, Biosensing, and Diagnostics explores how multifunctional nanocarriers are being used in combined delivery and diagnostics in contemporary medicine. Particular attention is given to efforts to i) reduce the side effects of therapeutic agents, ii) increase the pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. The chapters focus on applications of nanostructured materials and nanocarriers, highlighting how these can be used effectively in both diagnosis and delivery.
Multifunctional Pharmaceutical Nanocarriers
Various pharmaceutical nanocarriers, such as nanospheres,nanocapsules, liposomes, micelles, cell ghosts, lipoproteins and some others are widely used for experimental (and already clinical) delivery of therapeutic and diagnostic agents. The use of nanoparticulate pharmaceutical carriers to enhance the in vivo efficiency of many drugs well established itself over the past decade both in pharmaceutical research and clinical setting.
Multidetector-Row CT Angiography
Multidetector-row CT has dramatically improved the results of computed tomography in all clinical applications, but its beneficial impact has been most striking in vascular imaging. The simplicity of acquisition and the wide availability of equipment make this modality especially suitable for routine clinical application. In this book the basic aspects of multidetector-row CT angiography are comprehensively reviewed. Individual chapters are included on technical principles, image processing techniques and contrast agent administration. All clinical applications are then discussed in depth, with lucid descriptions of the examination technique for particular clinical indications and of the findings that characterize specific diseases. Limitations and advantages in comparison with other imaging modalities are considered. A large number of high-quality black and white and color illustrations help to explain the clinical findings.
Multi-Agent-Based Simulation VIII ; International Workshop, MABS 2007, Honolulu, HI, USA, May 15, 2007, Revised and Invited Papers
This book constitutes the thoroughly refereed post-proceedings of the 8th International Workshop on Multi-Agent-Based Simulation, MABS 2007, held in Honolulu, HI, USA in May 2007 as an associated event of AAMAS 2007, the main international conference on autonomous agents and multi-agent systems.The 10 revised full papers presented were carefully reviewed and selected from 20 submissions.The papers are organized in topical sections on architectures; teams, learning, education; economy, trust and reputation.
Multi-Agent-Based Simulation VII ; International Workshop, MABS 2006, Hakodate, Japan, May 8, 2006, Revised and Invited Papers
This book constitutes the thoroughly refereed proceedings of the 7th International Workshop on Multi-Agent-Based Simulation, MABS 2006. The 12 revised full papers presented together with three short papers and two invited papers were carefully reviewed and selected from 25 submissions during two rounds of reviewing.
Multi-Agent-Based Simulation VI ; International Workshop, MABS 2005, Utrecht, The Netherlands, July 25, 2005, Revised and Invited Papers
This book constitutes the thoroughly refereed post-proceedings of the 6th International Workshop on Multi-Agent-Based Simulation, MABS 2005, held in Utrecht, The Netherlands in July 2005 as an associated event of AAMAS 2005, the main international conference on autonomous agents and multi-agent systems. The 12 revised full papers presented together with 1 invited talk were carefully reviewed. The papers are organized in topical sections on coalition emergence, theories and models, applications, and environments.
Multi-Agent Systems and Applications V ; 5th International Central and Eastern European Conference on Multi-Agent Systems, CEEMAS 2007, Leipzig, Germany, September 25-27, 2007, Proceedings
The technical research paper section of the proceedingscontains pure - search papers as well as research results in application settings. The goal is to demonstrate the real-life value and commercial reality of multi-agent systems as well as to foster the communication between academia and industry in this eld.
Multi-Agent Systems and Applications IV ; 4th International Central and Eastern European Conference on Multi-Agent Systems, CEEMAS 2005, Budapest, Hungary, September 15-17, 2005, Proceedings
In the very competitive field of agent oriented conferences and workshops nowadays (such as AAMAS, WI/IAT, EUMAS, CIA, MATES) the special profile of CEEMAS is that it is trying to bridge the gap between applied research achievements and theoretical research activities. Our ambition is to provide a forum for presenting theoretical research with an evident application potential, implemented application prototypes and their properties, as well as industrial case studies of successful (but also unsuccessful) agent technology deployments. This is why the CEEMAS proceedings volume provides a collection of research and application papers. The technical research paper section of the proceedings (see pages 11–499) contains pure research papers as well as research results in application settings while the application papers section (see pages 500–530) contains papers focused on application aspects. The goal is to demonstrate the real life value and commercial reality of multi-agent systems as well as to foster communication between academia and industry in this field.
Multi-Agent Systems and Applications ; 9th ECCAI Advanced Course ACAI 2001 and Agent Link's 3rd European Agent Systems Summer School, EASSS 2001, Prague, Czech Republic, July 2-13, 2001. Selected Tutorial Papers
The Advanced Course on Artificial Intelligence ACAI 2001 with the subtitle M ulti- Agent Systems and Their Applications , held in Prague, Czech Republic, was a joint event of ECCAI (the European Coordinating Committee for Artificial Intelligence) and AgentLink, the European Network of Excellence for Agent-Based Computing. Whereas ECCAI organizes two-week ACAI courses on different topics every second year, AgentLink s European Agent Systems Summer School (EASSS) has been an annual event since 1999. This year, both of these important events were merged together, giving weight to the fact that multi-agent systems currently represent one of the hottest topics in AI research. The name, ACAI 2001 Summer School, is intended to emphasize that this event continues the tradition of regular ECCAI activities (ACAI), as well as the EASSS summer schools of AgentLink.
Multiagent System Technologies ; Vol. 4196 ; 4th German Conference, MATES 2006, Erfurt, Germany, September 19-20, 2006, Proceedings
This book constitutes the refereed proceedings of the 4th German Conference on Multiagent Systems Technologies, MATES 2006, co-located with Net.ObjectDays (NoDe 2006). The 15 revised full papers presented were carefully reviewed and selected from 52 submissions. The papers are organized in topical sections on agent communication and interaction, applications and simulation, agent planning, agent-oriented software engineering, as well as trust and security.
Multiagent System Technologies ; Vol. 3550 : 3rd German Conference, MATES 2005, Koblenz, Germany, September 11-13, 2005, Proceedings
After two successful MATES conferences in Erfurt 2003 and 2004, the 3rd G- man conference on Multi-agent System Technologies (MATES 2005) took place in Koblenz, Germany, in September 2005, and was co-located with the 28th German Conference on Arti?cial Intelligence (KI 2005). Building onotheragent-related events in Germany in the past, and organized by the GI German Special Interest Group on Distributed Arti?cial Intelligence, the MATES conference series aims at promoting the theory and applications of agents and multiagent systems. In corporating the 9th International Workshopon Cooperative Information Agents (CIA 2005), the topics of interest for MATES 2005 also covered the ?elds of intelligent information agents and systems for the Internet and the (Semantic) Web. As in recent years, MATES 2005 provided a distinguished, lively and int- disciplinary forum for researchers, users, and developers of agent technology, to present and discuss the latest advances of research and development in the area of autonomous agents and multiagent systems. Accordingly, the topics of MATES 2005 covered the whole range from the theory to applications of age- and multiagent technology. The technical program included a total of 24 sci- ti?c talks, and demonstrations of selected running agent systems, and both the MATES 2005 Best Paper and the CIA 2005 System Innovation awards.
Multiagent System Technologies ; 6th German Conference, MATES 2008, Kaiserslautern, Germany, September 23-26, 2008. Proceedings
This book constitutes the refereed proceedings of the 6th German Conference on Multiagent Systems Technologies, MATES 2008, held in Kaiserslautern, Germany, in September 2008 - co-located with the 31st German Conference on Artificial Intelligence, KI 2008.The 16 revised full papers presented together with 2 invited talks were carefully reviewed and selected from 35 submissions. The papers present and discuss the latest advances of research and development in the area of autonomous agents and multiagent systems ranging from theoretical and methodological issues to applications in various fields.
Multiagent System Technologies ; 5th German Conference, MATES 2007, Leipzig, Germany, September 24-26, 2007, Proceedings
The papers are organized in topical sections on engineering multi-agent systems, multi-agent planning and learning, multi-agent communication, interaction, and coordination, multi-agent resource allocation, multi-agent planning and simulation, as well as trust and reputation.
Multi-Agent Programming : Languages, Platforms and Applications
Part I describes four approaches that are based on computational logic or process algebra--Jason, 3APL, IMPACT, and CLAIM/SyMPA. These programming languages have formal semantics and use heavy machinery based on formal methods, but also provide working platforms for the development of multi-agent systems. Part II presents agent languages and platforms that extend or are based on Java--JADE, Jadex, and JACKTM. Although these have no formal semantics, the languages are well documented and the platforms provide a variety of tools that have been extensively used in practice. Part III provides two significant industry specific applications--The DEFACTO System for coordinating human-agent teams for the future of disaster response, and the ARTIMIS rational dialogue agent technology. The book also features seven appendices, summarising each of the agent programming languages, hence facilitating comparison of the approaches. In particular, Appendix A describes the criteria used for comparing the agent languages and platforms.
Multiagent Engineering : Theory and Applications in Enterprises
1 Multiagent Engineering: A New Software Construction Paradigm Multiagent systems have a long academic tradition. They have their roots in distributed problem solving in Artificial Intelligence (AI) from where they emerged in the mid-eighties as a distinctive discipline. Research in multiagent systems owes much to the work of Rosenschein on rationality and autonomy of intelligent agents, the European MAAMAW workshop series
Multiagent based Supply Chain Management
The authors takes a close look at what has been done recently in the field of supply chain management using agent technology and more specifically multiagent systems. The book contains sixteen chapters organized in four main parts; Introductory Papers; Multiagent Based Supply Chain Modeling, Collaboration and Coordination Between Agents in a Supply Chain and Multiagent Based Supply Chain Management: Applications. This book is intended as reference material for researchers, graduate students, and practitioners alike who are interested in pursuing research and development in this area, and who need for that, a comprehensive view of the existing literature, and some ideas for future directions.
Multi-Agent and Multi-Agent-Based Simulation ; Joint Workshop MABS 2004
The aim of the workshop was to provide a forum for work in both appli- tions of multi-agent-based simulation and the technical challenges of simulating large multi-agent systems (MAS). There has been considerable recent progress in modelling and analyzing multi-agent systems, and in techniques that apply MAS models to complex real-world systems such as social systems and organi- tions. Simulation is an increasingly important strand that weaves together this work. In high-risk, high-cost situations, simulations provide critical cost/benefit leverage, and make possible explorations that cannot be carried out in situ: – Multi-agent approaches to simulating complex systems are keytools in interdisciplinary studies of social systems. Agent-based social simulation (ABSS) research simulates and synthesizes social behavior in order to understand real social systems with properties of self-organization, scalability, robustness, and openness. – In the MAS community, simulation has been applied to awide range of MAS research and design problems, from models of complex individual agents - ploying sophisticated internal mechanisms to models of large-scale societies of relatively simple agents which focus more on the interactions between agents.
