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Bone Morphogenetic Proteins : From Local to Systemic Therapeutics
Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs.
Acquired Brain Injury : An Integrative Neuro-Rehabilitation Approach
Regardless of etiology, such as accident, tumor, stroke or assault, acquired brain injury presents numerous challenges for survivors, caregivers and treating professionals. Interdisciplinary and integrated evaluations, treatment, and management can mean the difference between successful recovery and unfortunate outcomes. The first book to present a comprehensive team approach to rehabilitation of ABI survivors, Acquired Brain Injury gives medical and clinical specialists a deeper understanding of not only each others' roles, but also their complementary functions.
