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Biomarkers as targeted herbal drug discovery : A pharmacological approach to nanomedicines
Looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid. Reviews the literature on inflammatory biomarkers in the treatment of diseases Looks at the development of herbal drug discovery based on biomarkers Explores emerging concepts of nanomedicines for herbal drug delivery Takes an interdisciplinary approach, with application to disciplines related to medical, pharmaceutical, biotechnological, Ayurvedic, Unani and biomedical engineering fields
Biologics in General Medicine
The idea for this book was born during the symposium on biologics organized by ZAFES (Center for Drug Research, Development and Safety at the University of Frankfurt am Main) in September 2005. Highly distinguished researchers special- ing in the field of biologics had gathered together to exchange information on this relatively new subject. Realizing that this symposium was one of the few sources of condensed information on biologics, it became obvious that we had to create a means of informing an interested wider circle of scientists and especially general c- nicians. Therefore, the editors of this book suggested to the researchers at the symposium andalsotoprominent scientists andcliniciansinvolvedinthe developmentand application of biologics as their major field of interest the idea of assembling this compendium. We received an overwhelmingly positive response – thankfully also from the publisher – most being more than willing to support this innovative project with highly relevant chapters on the latest state of the art.
Bioactives and pharmacology of medicinal plants : Vol.1
Bioctives and Pharmacology of Medicinal Plants, concisely presents an abundance of important information on the bioactive and pharmacological properties of medicinal plants. It provides valuable comprehensive research and studies on bioactive phytocompounds of over 68 important medicinal plants with beneficial properties. For each species included in the volume, a brief introduction is given along with their bioactive compounds and chemical structures, followed by their chief pharmacological activities that include antiviral, antimicrobial, antioxidant, anti-cancer, anti-inflammatory, antidiabetic, hepatoprotective, nephroprotective, and cardioprotective activities. A review of the published literature on pharmacological activities on each species is included also, providing a thorough resource on each of the plants covered in the volume.
Bioactives and pharmacology of Legumes
A variety of bioactives and therapeutics from the legume family (Fabaceae or Leguminosae) are thoroughly detailed. For each species included in the volume, a brief introduction is given, the plant’s bioactive compounds are listed, and its chemical structures shown, followed by their pharmacological activities. Many of these plants have medicinal activities that include antiviral, antimicrobial, antioxidant, anticancer, anti-inflammatory, and antidiabetic, hepatoprotective, nephroprotective and cardioprotective. The biochemical characteristics of the 37 plants included, such as the type of starch, protein, and fibers, can be exploited as binders, excipients, thickeners, and dispersants in the formulation of various products in the pharmaceutical industry. The published literature on the pharmacological activities on each species is reviewed and presented in a concise and clear manner.
Bioactives and pharmacology of lamiaceae
Provides a wealth of information on plants in the Lamiaceae family, noted for their essential oils and bioactives and pharmacological properties. The chapters investigate a wide variety of species, providing for each an introduction, characteristics, properties, distribution, traditional uses, and current and potential pharmacological applications. Aiming to be a resource for the development of new drugs based on species within the Lamiaceae family, the volume discusses 26 species, including bungleweed (Ajuga), Malabar catmint (Anisomeles malabarica), beechwood (Gmelina arborea), Brazilian mint (Hyptis crenata), rosemary (Rosmarinus officinalis L.), holy basil (Ocimum tenuiflorum), and many more.
Bioactive Molecules and Medicinal Plants
Use of medicinal plants is as old as human civilization and continuous efforts are being made to improve medicinal plants or produce their products in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identifed from higher plants and microorganisms. Some plant-based drugs have been used for centuries and there is no alternative medicine for many drugs, such as cardiac glycosides. However, natural products research was sidelined to pave the way for com- natorial chemistry, which was expected to produce large numbers of synthetic compounds for high-throughput screening (HTS). This line of work has failed to deliver desirable results. Moreover, it is not possible for all pharmaceutical companies and institutions to adopt costly HTS technology. Therefore, medi- nal plants and their bioactive molecules are always in demand and are a central point of research. While planning this book, we endeavored to incorporate - ticles that cover the entire gamut of current medicinal plants research.
Behavioral pharmacology of the cholinergic system
The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.
Bee products and their applications in the food and pharmaceutical industries ; 1st ed.
Focuses on the health benefits of selected bee products by looking more closely at their pharmacological potentials and therapeutic applications in coping with various diseases. The book explores some of these products, such as royal jelly, propolis and bee venom, which is highly attractive to the food supplement sector due to the biological actions that are proved by scientific studies. Bee products also attract the cosmetics industry by utilizing those products in various applications such as hair products, toothpaste, sunscreen creams, lip balsams, or facial moisturizing creams. Each chapter focuses on a particular health benefit, providing more compact and detailed information about each activity for a specific interest. The mainframe of the book is based on the medicinal and pharmacological functions of bee products, with the therapeutic applications for each bee product supporting the mechanism of action of their biological functions.
Bee products : Chemical and biological properties
Presents an updated discussion on the chemical composition and biological properties of the main bee products, which until now have been presented separately in different editions This book scoops out studies about bee products most used in marketing and in traditional medicine such as honey, royal jelly, propolis, bee pollen and bee venom Discusses chemical composition and biological function of the different bee products on topics such as nutrition, aging and age-related diseases, cancer, neurodegenerative diseases and pathogen infections Bee products are rich in several essential nutrients and non essential nutrients, as sugars, minerals, proteins, free amino acids, vitamins, enzymes and polyphenols, that seem to be closely related to their biological functions. The effects of these products in nutrition, aging and age-related diseases, cancer, neurodegenerative diseases and pathogen infections are discussed.
Basiswissen pharmakologie = Basic knowledge of pharmacology
Offers a clear and concise overview of all exam-relevant pharmacology content. It guides you through the entire foundational knowledge, from the basics to the most important clinical pictures, in an easily understandable way and aligned with the German National Competency-Based Learning Objectives for Medicine (GK) and National Competency-Based Learning Objectives for Medicine (NKLM). Benefit from the lecturer's many years of experience, who has carefully selected and presented the essential information for you.
Basic principles of drug discovery and development ; 2nd ed.
Presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields.
Basic pharmacokinetics
Introduces basic pharmacokinetic concepts to beginner learners to help them understand the absorption, distribution, metabolism, and excretion of drugs. Accompanying the book is a website with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.
Basic knowledge of pharmacology
Concise and up-to-date coverage of the most important drugs Integration of experimental and clinical pharmacology with focus on diseases Discusses the most important drugs (400) in the context of relevant diseases. Summary tables and schemes, MCQ exam questions, case studies and a list of drugs aid memorization of the material before an exam. All chapters are written in the same concise style and use a modern and precise pharmacological nomenclature. After reading of the book, the student will be able to critically assess the proper use of the most important drugs and advise patients properly. The didactic concept of the book has been developed on the author’s own pharmacology courses for which he has received numerous teaching awards. The book takes advantage of the learning spiral, in which material is presented repeatedly from various angles.
Basic & Clinical Pharmacology
Covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters
Barile's clinical toxicology : Principles and mechanisms ; 3rd ed.
Examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. Special emphasis is placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs. Includes the source, pharmacological and toxicological mechanism of action, detection and identification in body fluids, and treatment of exposure. An overview of protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology, are discussed. In addition, effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered
Aulton's pharmaceutics : The design and manufacture of medicines
Offers a complete course in one book for students in all years of undergraduate pharmacy and pharmaceutical sciences degrees. Thoroughly revised, updated and extended by experts in their fields and edited by Professors Kevin Taylor and Michael Aulton, this new edition includes the science of formulation, pharmaceutical manufacturing and drug delivery. All aspects of pharmaceutics are covered in a clear and readily accessible way and extensively illustrated throughout, providing an essential companion to the entire pharmaceutics curriculum from day one until the end of the course. Fully updated throughout, with the addition of new chapters, to reflect advances in formulation and drug delivery science, pharmaceutical manufacturing and medicines regulation Designed and written for newcomers to the design and manufacture of dosage forms Relevant pharmaceutical science covered throughout Includes the science of formulation and drug delivery Reflects current practices and future applications of formulation and drug delivery science to small drug molecules, biotechnology products and nanomedicines Key points boxes throughout Over 400 online multiple choice questions
Asymmetric synthesis of drugs and natural products
Focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations
Artificial intelligence in oral health
Intended to lay the foundation of AI applications focusing on oral health, including general dentistry, periodontology, implantology, oral surgery, oral radiology, orthodontics, and prosthodontics, among others.
Artificial intelligence in drug design
Looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future.
Aromatase Inhibitors
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
