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Biotechnologies for plant mutation breeding : Protocols
This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.
Biosurfactants for a sustainable future : Production and applications in the environment and biomedicine
The book emphasizes the different techniques that are used for the production of biosurfactants from microorganisms and their characterization. Various aspects of biosurfactants, including structural characteristics, developments, production, bio-economics and their sustainable use in the environment and biomedicine, are addressed, and the book also presents metagenomic strategies to facilitate the discovery of novel biosurfactants producing microorganisms.
Biosaline Agriculture and Salinity Tolerance in Plants
This volume focuses on reclamation, management, and utilization of salt-affected soils, their sustainable use, and evaluation of plants inhabiting naturally occurring saline habitats. It is of interest to scientists and students as well as to agricultural institutions and farmers and will undoubtedly raise the scientific community's awareness of, and interest in salinity issues.
Biopharmaceutics applications in drug development
This book introduces fundamental concepts, methods, and advances in the areas of dissolution, absorption, and permeability and their key applications in dosage form performance. Case studies are used to discuss the applications of biopharmaceutic strategies in the development of successful drugs, with a specific focus on the applications of biopharmaceutic strategies in the development of successful drugs. The book presents an integrated view in linking pharmaceutic to the biological consequences of drug products and leverages those for decision making in drug development.
Biopharmaceutical processing : Development, design, and Implementation of manufacturing processes
Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies.
Biomaterials and bionanotechnology ; 1st ed.
Examines the current state of the field within pharmaceutical sciences and concisely explains the history of biomaterials including key developments. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biomaterials and bionanotechnology within drug discovery and drug development. Each chapter delves into a particular aspect of this fast-moving field to cover the fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to transform a drug candidate or new chemical entity into a final administrable dosage form, with particular focus on biomaterials and bionanomaterials. This book provides a comprehensive examination suitable for researchers working in the pharmaceutical, cosmetics, biotechnology, food and related industries as well as advanced students in these fields.
Biomarkers for alzheimer’s disease drug development
Aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer’s disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer’s disease, cutting-edge developments in neuropathology and their relevance for Alzheimer’s disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Biomarkers as targeted herbal drug discovery : A pharmacological approach to nanomedicines
Looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid. Reviews the literature on inflammatory biomarkers in the treatment of diseases Looks at the development of herbal drug discovery based on biomarkers Explores emerging concepts of nanomedicines for herbal drug delivery Takes an interdisciplinary approach, with application to disciplines related to medical, pharmaceutical, biotechnological, Ayurvedic, Unani and biomedical engineering fields
Biology and Ecology of Norway Spruce
This book presents a concise and comprehensive review of the biology, ecology, and management of Norway spruce. It integrates classic and contemporary literature (more than 2000 works cited in the text), highlighting basic research and forestry practices in central and eastern Europe. The topics include anatomy and morphology, physiology and nutrition, reproductive biology and genetics, and ecology. In addition, it examines mycorrhiza, diseases and pests as well as silviculture and wood products. In the light of increasing threats to forest health from air pollution, climate change, and insects and disease, it provides an essential information source to those concerned with the ecology, conservation, and management of the species
Biologie und epidemiologie der hormonersatztherapie : Diskussionen zur postmenopausalen gesundheit = Biology and epidemiology of hormone replacement therapy : Discussions on postmenopausal health
The advantages and disadvantages of hormone replacement therapy (HRT) are discussed by a group of experts with regard to the epidemiological evidence. However, the focus of the discussion is the problem of breast cancer risk. Among other things, it is shown that the results derived from epidemiological studies do not coincide with the growth characteristics of these tumors, so that further population studies with the inclusion of pathobiological expertise appear necessary. The benefits and risks of hormone replacement therapy (HRT) are discussed by a group of experts with a view towards the evidence provided by recent epidemiological studies. Although all aspects of HRT indications and contra-indications are reviewed, the particular emphasis of this discussion is on breast cancer. Among other things, it is shown that the evidence on breast cancer provided in epidemiological studies does not match the growth characteristics of the tumors, and that further population research incorporating pathobiological assessments is required.
Biological, chemical, and radiological Terrorism : Emergency preparedness and response for the primary care physician
This book provides sought-after guidance to primary care physicians on preparing for and responding to terrorist events. Chapters offer a fundamental understanding of the epidemiology and relevant clinical aspects of diseases caused by biological agents (anthrax, plague, smallpox, botulism, tularemia, and hemorrhagic viruses), chemical agents (nerve and blister), and radiological agents. The text details how to detect terrorist-caused illness as early as possible, how to provide defensive or preventive therapy, and how to triage and treat ill patients. Emphasis is placed on addressing both the physical and psychological impact on patients and providers.
Biological Low-Voltage Scanning Electron Microscopy
Biological Low-Voltage Scanning Electron Microscopy is the first book to address both of these aspects of biological LVSEM. After providing a thorough description of the unique advantages and the operating constraints related to operating a scanning electron microscope at low beam voltage, the remainder of book focuses on the the best way to image all types of plant and animal cells and covers specimens that range from macromolecules to the surfaces revealed by de-embedding resin-embedded samples. Advanced specimen preparation techniques such as cryo-LVSEM, and immuno-gold-LVSEM are fully covered, as is x-ray microanalysis at low beam voltage and live-time stereo imaging. The preparative protocols provided represent the distilled essence of the experience of a group of world-renowned authors who have, for many decades, been instrumental in developing and applying new approaches to LVSEM to support their own biological research.
Biological Invasions in New Zealand
Man’s recent colonization of New Zealand has dramatically altered the resident biota and resulted in the introduction of numerous alien organisms to these once remote islands. In reverse, there is increasing evidence of a lesser known export of species to other regions of the world. This volume presents an in-depth review of the level and rate of such invasions, and investigates what controls the success of invaders and the consequences for ecosystems both on land and offshore. It provides invasion biologists everywhere with tests of current theories about those factors leading to the success of invaders as well as evaluating principles for understanding the nature of their impacts that form a solid basis for the effective management of biological invasions worldwide.
Biological Invasions Belowground : Earthworms as Invasive Species
he most conspicuous biological invasions in terrestrial ecosystems have been by exotic plants, insects and vertebrates. Less conspicuous but possibly of equal importance are invasions by soil invertebrates, which are occurring literally beneath our feet. Familiar examples include the South American fire ant (Solenopsis invicta) which has invaded North America and Australia, and the New Zealand flatworm (Arthurdendyus triangulatus) which has become wide-spread in the United Kingdom; both have caused considerable ecological and economic damage. There is now evidence that exotic earthworm invasions are increasing world-wide and may be having significant impacts on soil processes and plant communities in some regions. Much remains to be learned about these ‘cryptic’ biological invasions. The papers in this book are based on efforts by an international group of soil ecologists to assess the biological and ecological mechanisms of earthworm invasions, their geographic extent and impacts on terrestrial ecosystems, and possible means by which earthworm invasions might be mitigated.
Biological Invasions
This new volume on Biological Invasions deals with both plants and animals. It differs from previous books on the subject by extending from the level of individual species to an ecosystem and global level. Topics of highest societal relevance, such as the impact of genetically modified organisms, are interlinked with more conventional ecological aspects, including biodiversity. The combination of these approaches is new and makes compelling reading for researchers and environmentalists. The book’s 22 chapters cover a huge range of subjects relevant to the field. These include pathways of biological invasions (e.g. ballast water, waterways), traits of successful invaders (e.g. chemical weapons, empty niches), and patterns of invasion and invasibility, such as man-induced predisposition by fire, land use and eutrophication, and the role of climate change.
Biological invaders in inland waters : Profiles, distribution, and threats
The book examines the identity, distribution, and impact of freshwater non-indigenous species and the dynamics of their invasion. Rather than providing a broad and comprehensive review of the issue, Biological invaders in inland waters focuses on old and new invaders and also raises questions and opens perspectives that provide a starting point for further research. The ultimate purpose of this book is to help define a more general framework for our knowledge of invasions in fresh waters. Such a framework will be indispensable to the planning of a science-based management program.
Biological Calcification : Normal and Pathological Processes in the Early Stages
This book follows a precursor volume devoted to biological calci?cation, - sued by the CRC Press, Boca Raton (Florida) in 1992. Several basic aspects of the calci?cation process were analyzed in it by outstanding authors who had unquestioned competence in their respective research areas. Its main aim was that of giving readers access to a series of papers which, even though they discussed divergent aspects of biological calci?cations drawn from the study of systems as different as vertebrate skeletons and mollusks, in vitro cultures and unicellular organisms, ectopic calci?cation and urinary stones, provided elements permitting a coherent approach to a comprehensive view of the calci?cation process in biological tissues.
Biological Basis of Geriatric Oncology
Biological Basis of Geriatric Oncology highlights research issues that are specific to geriatric oncology in the field of carcinogenesis and cancer prevention and treatment, based on the biologic interactions of cancer and age. It illustrates the benefit of the principles of geriatrics in the management of cancer in the older individual.
Bioinspired engineering of thermal materials
A comprehensive overview and summary of recent achievements and the latest trends in bioinspired thermal materials. Following an introduction to different thermal materials and their effective heat transfer to other materials, the text discusses heat detection materials that are inspired by biological systems, such as fire beetles and butterflies. There then follow descriptions of materials with thermal management functionality, including those for evaporation and condensation, heat transfer and thermal insulation materials, as modeled on snake skins, polar bears and fire-resistant trees.
Bioinformatics and systems biology : Collaborative research and resources
Collaborative research in bioinformatics and systems biology is a key element of modern biology and health research. This book highlights and provides access to many of the methods, environments, results and resources involved, including integral laboratory data generation and experimentation and clinical activities. Collaborative projects embody a research paradigm that connects many of the top scientists, institutions, their resources and research worldwide, resulting in first-class contributions to bioinformatics and systems biology. Central themes include describing processes and results in collaborative research projects using computational biology and providing a guide for researchers to access them. The book is also a practical guide on how science is managed. It shows how collaborative researchers are putting results together in a way accessible to the entire biomedical community.
