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Ontologies for Software Engineering and Software Technology
The editors structured the contributions into three parts: first, a detailed introduction into the use of ontologies in software engineering and software technology in general; second, the use of ontologies to conceptualize different process-related domains such as software maintenance, software measurement, or SWEBOK, initiated by IEEE; third, the use of ontologies as artifacts in several software processes, like, for example, in OMG’s MOF or MDA.
One-Dimensional Nanostructures
One-dimensional (1D) nanostructures, including nanowires, nanotubes and quantum wires, have been regarded as the most promising building blocks for nanoscale electronic and optoelectronic devices. Worldwide efforts in both the theory and the experimental investigation of growth, characterization and applications of 1D nanostructures have resulted in a mature, multidisciplinary field. In this book, a wealth of state-of-the-art information offers the opportunity to uncover the underlying science from diverse perspectives. Leading researchers elucidate the synthesis and properties of 1D nanostructures for various morphologies and compositions (semiconductor, metal, carbon, etc.) as well as their considerable impact on spintronics, information storage, and the design of field-effect transistors.
Ondansetron Patches
The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.
Oncology : An Evidence-Based Approach
Reflect the principles and current practice of oncology with contributors from the fields of medical, surgical, and radiation oncology. The textbook will incorporate an evidence-based approach, enabling the reader to make decisions on the basis of concrete data. Sections on solid tumors, hematologic malignancies and the practice of oncology address the natural history and therapy for the full spectrum of neoplastic diseases in the adult. Further sections present fundamentals of supportive care of the cancer patient, the management of oncologic emergencies and acute toxicities of therapy, as well as care of metastatic disease and the terminally-ill patient. Breaking new ground, the textbook features thoughtful, in-depth sections on cancer prevention and control, cancer surviorship, the economics of cancer care, and cancer informatics. Cancer imaging is covered with an organ system-based approach, with an additional chapter on the especially intriguing potential of PET. Furthermore, a comprehensive section on translational basic science reviews the fundamentals of molecular biology, the cell cycle and signal transduction, carcinogenesis, cancer genetics, the biology of invations and metastasis, and tumor immunology.
Oncologic and Cardiologic PET/CT-Diagnosis : An Interdisciplinary Atlas and Manual
Since 1999/2000 simultaneous imaging of anatomical features and metabolic activities using fused PET and CT images has complemented and in many cases even replaced what was originally done as separate analysis. – Is this a small revolution? – In fact, this new approach can be considered to be without a rival for imaging diagnosis. The complementary efforts of nuclear medicine physicians and radiologists have improved the diagnostic value of PET/CT scans. The successful use of PET/CT in the field of oncology has been documented world-wide, and in cardiology we can take advantage of the significant findings of PET diagnosis, particularly in the USA. New prospects are now available for paediatric oncology and molecular medicine.
Oncogenes Meet Metabolism : From Deregulated Genes to a Broader Understanding of Tumour Physiology
In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
Omics sudies of medicinal plants
Herbal drugs play a pivotal role in modern medicine and pharmaceutical care; however, only limited biotechnology applications have been seen in medicinal plants. Revolutions in high-throughput approaches emphasize omics approaches, such as genomics, transcriptomics, proteomics, and metabolomics. A volume in the Exploring Medicinal Plants series, this book provides a comprehensive and in-depth analysis of breakthroughs in high-throughput approaches for the research of medicinal plants.
Objective information theory
Objective Information Theory (OIT) is proposed to represent and compute the information in a large-scale complex information system with big data in this monograph. To formally analyze, design, develop, and evaluate the information, OIT interprets the information from essential nature, measures the information from mathematical properties, and models the information from concept, logic, and physic. As the exemplified applications, Air Traffic Control System (ATCS) and Smart Court SoSs (System of Systems) are introduced for practical OITs.
Nutritional psychiatry
Provides a comprehensive overview of nutritional psychiatry, elucidating its theoretical foundations, the biological mechanisms linking diet to mental health (including inflammation, oxidative stress, disrupted energy metabolism the gut–brain axis and other implicated pathways), and the current evidence base for dietary impacts on major psychiatric disorders such as depression, anxiety, schizophrenia, bipolar disorder, and ADHD.
Nutrition in Kidney Disease
The field of kidney disease has evolved over the years to encompass a broad and sophisticated knowledge base. There has been a proliferation of scientific information and technical advances in the field. In Nutrition in Kidney Disease, the authors provide a comprehensive perspective of the emerging science in nutrition in kidney disease. This important book is written by a collaborative group of distinguished dietitians and physicians in the specialized field of kidney disease and clinical nutrition, who have devoted their careers to the care of patients with kidney disease. At the end of key chapters, case studies assess knowledge of the subject within the context of didactic curriculums.
Nutrition and dietary interventions in cancer
Presents the most up-to-date information on the effects of nutrition and food on cancer prevention and management. The book will provide clinicians and other healthcare practitioners with an educational source on how to educate cancer patients and their families on nutrition and dietary during cancer treatment. Recent nutritional epidemiology studies have occasionally produced controversial or unexpected results and highlight the need for additional research on diet and cancer risk. Chapters within the book focus among others on the role of natural antioxidants in cancer, the importance of micronutrients in cancer prevention and nutritional genomics and their role in cancer prevention.
Nutrition and diet in health: Principles and applications
Food provides us with essential nutrients involved in many physiological activities and biological processes in the body including growth and development, metabolism, immune function, and overall well-being. Nutrition and Diet in Health: Principles and Applications reviews and discusses the issues related to the roles of nutrition and diets in human health and diseases. The book contains two sections - one section features principles, the other, covers applications. Part One provides information on sustainable use of nutrition and diets in health and diseases; advanced biotechnological approaches to improve nutritional content of food; trace elements in nutrition; drug and nutrient interactions; functional foods and nutraceuticals in health maintenance; and Bio markers of functional foods and nutraceuticals in health maintenance. Part Two discusses the significance of nutrition in selected human diseases, including cardiovascular diseases, cancer, infection, neurodegenerative diseases, and metabolic co-morbidities. It also discusses optimal nutrition for wellness, fitness, pregnancy, mental health, aging, and longevity.
Nutraceuticals in obesity management and control
Provides detailed information on nutraceuticals that can be helpful in the control and management of obesity. It clarifies key aspects of nutraceuticals that include sources, extraction, chemistry, mechanisms of action, pharmacology, bioavailability, safety, and various applications. Beginning with a concise overview of the prevalence of obesity, complications related to obesity, and current treatment regimens, the volume delves into the roles of functional foods and nutraceuticals for the management of body weight and for alleviating obesity comorbidities. It goes on to discuss the effect of some of the most commonly and frequently used naturally occurring nutraceutical substances, along with their mechanisms of action in controlling obesity. The volume looks at the role of nutraceutical fruits as well as the beneficial aspects of carotenoids in fruits and vegetables and explores antioxidant-rich nutraceuticals, the role of vitamins and supplements, the use of green tea, and the potential of pseudocereals and spices in the management of metabolic syndrome.
Nutraceuticals in insomnia and sleep problems
Sleep is one of the most important and crucial physiological needs for maintaining a healthy life. However, in today’s day and age, insomnia and other sleep disorders, such as sleep apnea, are increasing rapidly. This new book details the nutraceuticals from foods that help to promote good health and optimum sleep. The authors discuss the importance of sleep, the role of diet in sleep, the role of specific vitamins and minerals, amino acids and opioids as nutraceuticals for sleep, newer technologies for use and delivery of nutraceuticals for treating insomnia, and more. The book not only explores nutraceuticals that promote optimum sleep but also details foods that cause insomnia, such as processed, chemical-rich, and refined foods. Chapters also cover commensal and symbiotic microbes, microbial metabolites, and bacteriocins and their impact on sleep. A chapter on the ethical issues related to addiction to nutraceuticals for sleep induction is also included.
Nutraceutical fruits : Overview and disease prevention
While nutritional supplements have enormous advantages, food ingredients such as fruits and vegetables can play a significant preventative and therapeutic role in our daily lives. Fruits are found to have anti-inflammatory, antibacterial, antifungal, and chemopreventive properties that can boost health, as well as prevent diseases. This new book explores the use of fruits as nutraceuticals for alternative treatment, as well as for disease prevention. It looks at how nutraceutical fruits can be used to prevent and manage a range of diseases that include mental illness, cancer, respiratory and lung diseases, cardiovascular diseases, liver disease, inflammatory bowel diseases, sleep disorders, etc. The book also looks at the roles of nutraceutical fruits in the metabolic syndrome and provides information regarding the safety and toxicity of neutraceutical fruits.
Numerical Methods and Applications ; 6th International Conference, NMA 2006, Borovets, Bulgaria, August 20-24, 2006, Revised Papers
This book constitutes the thoroughly refereed post-proceedings of the 6th International Conference on Numerical Methods and Applications, NMA 2006. The papers are organized in topical sections on numerical methods for hyperbolic problems, robust preconditioning solution methods, Monte Carlo and quasi-Monte Carlo for diverse applications, metaheuristics for optimization problems, uncertain/control systems and reliable numerics, interpolation and quadrature processes, large-scale computations in environmental modelling, and contributed talks.
Nuel Belnap on Indeterminism and Free Action
Seeks to further the use of formal methods in clarifying one of the central problems of philosophy: that of our free human agency and its place in our indeterministic world. It celebrates the important contributions made in this area by Nuel Belnap, American logician and philosopher. Philosophically, indeterminism and free action can seem far apart, but in Belnap’s work, they are intimately linked. This book explores their philosophical interconnectedness through a selection of original research papers that build forth on Belnap’s logical and philosophical work. Some contributions take the form of critical discussions of Belnap's published work, some develop points made in his publications in new directions, and others provide additional insights on the topics of indeterminism and free action.
Nucleic Acids and Proteins in Soil
With millions of different bacterial species living in soil, the microbial community is extremely complex, varying at very small scales. Microbe-driven functions are essential for most processes in soil. Thus, a better understanding of this microbial diversity will be invaluable for the management of the various soil functions. Nucleic Acids and Proteins in Soil combines traditional approaches in soil microbiology and biochemistry with the latest techniques in molecular microbial ecology. Included are methods to analyse the presence and importance of nucleic acids and proteins both inside and outside microbial cells, the horizontal gene transfer which drives bacterial diversity, as well as soil proteomes. Further chapters describe techniques such as PCR, fingerprinting, the challenging use of gene arrays for structural and functional analysis, stable isotope probing to identify in situ metabolic functions, and the use of marker and reporter genes in soil microbial ecology.
NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders : from Genes to Therapeutics
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders. The identification of multiple receptors for the members of the NPY and PYY family of peptides provides new opportunities for discovery of specific NPY antagonists and agonists that have vast clinical potential. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists, which are in clinical development for obesity. NPY Y1 receptor antagonists are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders is also actively pursued. The chapters in this book are written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.
Novel NMR and EPR Techniques
This book delivers a survey of recent research in the fields of condensed matter physics and chemistry based on novel NMR and ESR techniques. Applications include quantum computing, metal nanoparticles, low dimensional magnets, fullerenes as atomic cages, superconductors, porous media, and laser assisted studies. The book is dedicated to Professor Robert Blinc, on the occasion of his seventieth birthday, in appreciation of his remarkable scientific accomplishments in the NMR of condensed matter.
