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Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Liver carcinogenesis : Methods and protocols
Discusses the latest advancements in modern methodologies used to study liver carcinogenesis. The first half of this book describes pertinent preclinical models of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), established either through orthotopic induction of ectopic implantation. The second half of this book covers a diverse array of techniques applied to characterize the biochemical and cellular composition of hepatic malignancies that operate at the single-cell and histological levels. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Chemical and functional properties of food components
Described the contents of food raw materials and products, the chemistry/biochemistry of food components, as well as the changes occurring during post-harvest storage and processing affecting the quality of foods. Discusses the role of chemical compounds in the structure of raw materials and the formation of different attributes of food quality, including nutritional value, safety, and sensory properties. It contains four new chapters: “Non-Protein Nitrogenous Compounds”; “Prooxidants and Antioxidants in Food”; “Non-Nutritive Bioactive Compounds in Food of Plant Origin”; and “Analytical Methods Used for Assessing the Quality of Food Products.”
Boreal Peatland Ecosystems
This volume adopts an ecosystems approach to understanding the world's boreal peatlands. It focuses on biogeochemical patterns and processes, production, decomposition, and peat accumulation, and provides additional information on animal and fungal diversity. A recurring theme is the legacy of boreal peatlands as impressive accumulators of carbon as peat over millennia. This carbon legacy is under threat from a wide diversity of disturbances, including wildfire, ongoing climate change, the changing chemistry of atmospheric deposition, and continuing resource exploitation. The volume is of inte.
Bone densitometry for technologists
Radiologic technologists, nurse practitioners, physician assistants, and dedicated densitometry technologists can find new guidelines for bone density testing, new therapies for osteoporosis, and new treatment guidelines for osteoporosis, as well as new chapters on pediatric densitometry body composition assessments, and the use of skeletal morphometry in diagnosis and fracture risk prediction. The twelve appendices have also been updated to reflect the most current information available, including contacts for densitometry equipment manufacturers and organizations, guidelines for bone density testing and CPT codes, definitions of terms, and new conversion equations.
Bee products : Chemical and biological properties
Presents an updated discussion on the chemical composition and biological properties of the main bee products, which until now have been presented separately in different editions This book scoops out studies about bee products most used in marketing and in traditional medicine such as honey, royal jelly, propolis, bee pollen and bee venom Discusses chemical composition and biological function of the different bee products on topics such as nutrition, aging and age-related diseases, cancer, neurodegenerative diseases and pathogen infections Bee products are rich in several essential nutrients and non essential nutrients, as sugars, minerals, proteins, free amino acids, vitamins, enzymes and polyphenols, that seem to be closely related to their biological functions. The effects of these products in nutrition, aging and age-related diseases, cancer, neurodegenerative diseases and pathogen infections are discussed.
Basic methods for the biochemical lab
Covers : quantitative methods (proteins, nucleic acids, phospholipids and carbohydrates), electrophoresis (several polyacrylamide and agarose systems, 2D-PAGE, detection methods and affinity electrophoresis), chromatographic protocols (thin-layer chromatography, GPC, IEC, affinity chromatography, HPLC), immunochemical protocols (hapten-carrier and enzyme conjugation, immunization and antibody purification, immune affinity chromatography, ELISA), centrifugation (differential and density gradient centrifugation for cells and cellular fractions), radioactivity (labeling and counting), buffers (buffer properties and compositions).
Machine Learning and Probabilistic Graphical Models for Decision Support Systems
Presents recent advancements in research, a review of new methods and techniques, and applications in decision support systems (DSS) with Machine Learning and Probabilistic Graphical Models, which are very effective techniques in gaining knowledge from Big Data and in interpreting decisions. It explores Bayesian network learning, Control Chart, Reinforcement Learning for multicriteria DSS, Anomaly Detection in Smart Manufacturing with Federated Learning, DSS in healthcare, DSS for supply chain management, etc. Researchers and practitioners alike will benefit from this book to enhance the understanding of machine learning, Probabilistic Graphical Models, and their uses in DSS in the context of decision making with uncertainty. The real-world case studies in various fields with guidance and recommendations for the practical applications of these studies are introduced in each chapter.
Knowledge Processing with Interval and Soft Computing
In particular, these chapters cover computing techniques for interval linear systems of equations, interval matrix singular-value decomposition, interval function approximation, and decision making with statistical and graph-based data processing. To enable these applications, the book presents a standards-based object-oriented interval computing environment in C++.
Artificial intelligence hardware design : Challenges and solutions
Learn foundational and advanced topics in Neural Processing Unit design with real-world examples from leading voices in the field. A thorough introduction to neural networks and neural network development history, as well as Convolutional Neural Network (CNN) models Explorations of various parallel architectures, including the Intel CPU, Nvidia GPU, Google TPU, and Microsoft NPU, emphasizing hardware and software integration for performance improvement Discussions of streaming graph for massive parallel computation with the Blaize GSP and Graphcore IPU An examination of how to optimize convolution with UCLA Deep Convolutional Neural Network accelerator filter decomposition
Algebra, Meaning, and Computation ; Essays dedicated to Joseph A. Goguen on the Occasion of His 65th Birthday
This Festschrift volume - published to honor Joseph Goguen on his 65th Birthday on June 28, 2006 - includes 32 refereed papers by leading researchers in the different areas spanned by Joseph Goguen's work. The papers address a broad variety of topics from meaning, meta-logic, specification and composition, behavior and formal languages, as well as models, deduction, and computation.The papers were presented at a Symposium in San Diego, California, USA in June 2006.
AI in drug discovery
Constitutes the refereed proceedings of the First international workshop on ai in Drug Discovery, AIDD 2024, held as a part of the 33rd International Conference on Artificial Neural Networks, ICANN 2024, in Lugano, Switzerland, on September 19, 2024. These papers focus on various aspects of the rapidly evolving field of Artificial Intelligence (AI)-driven drug discovery in chemistry, including Big Data and advanced Machine Learning, eXplainable AI (XAI), Chemoinformatics, Use of deep learning to predict molecular properties, Modeling and prediction of chemical reaction data and Generative models.
Materials, Chemicals and Methods for Dental Applications
Focuses on the materials used for dental applications looking at the fundamental issues and the developments that have taken place the past decade. While it provides a broad overview of dental materials, the chemicals that are used for the preparation and fabrication of dental materials are explained as well. Also, the desired properties of these materials are discussed and the relevance of the chemical, physical, and mechanical properties is elucidated. Methods for the characterization and classification, as well as clinical studies are reviewed here. In particular, materials for dental crowns, implants, toothpaste compositions, mouth rinses, as well as materials for toothbrushes and dental floss are discussed. For example, in toothpaste compositions, several classes of materials an chemcials are incorporated, such as abrasives, detergents, humectants, thickeners, sweeteners, coloring agents, bad breath reduction agents, flavoring agents, tartar control agents, and others. These chemicals, together with their structures, are detailed in the text.
Bulk Fill Resin Composites in Dentistry : A Clinical Guide
Dedicated to all relevant aspects of bulk fill materials and their uses in clinical practice. Today, we count over 30 different bulk fill materials, which can be used in the dental clinic. The composition of bulk fill materials and their different modes of application for moderate to large direct resin restorations placement are explained in this book. It is written by a group of international specialists and allows the reader to evaluate available materials, learn predictable techniques and evaluate long term survival as well as future developments. The book covers all fields related to the history of bulk fill composites, their composition and physical properties, and a step by step guide to their successful clinical applications.
Bioactive Materials in Dentistry : Remineralization and Biomineralization
Addresses the use of different bioactive materials in dentistry, considering the performance of these biomaterials in the hard tissues of the tooth, and the response of the dental pulp, as well as the influence of the composition of these materials and of the individual’s systemic alterations in bioactivity and in antimicrobial activity. The several in vivo and in vitro tests to evaluate the bioactivity of a biomaterial will also be addressed.
Civil Engineering Materials for Transportation Infrastructure
Includes the fundamental mechanical and physical properties of materials; properties, tests, and gradation designs of aggregates; production, composition, hydration, properties, and tests of lime and cement; composition, tests, and design of cement concrete; mechanisms, properties, and design of inorganic binder stabilized material; properties, tests, and grading of asphalt; composition, properties, tests, and designs of asphalt mixture; and properties, treatments, tests, and selections of steel.
Civil engineering materials : From theory to practice ; 1st ed.
Presents the state-of-the-art in civil engineering materials, including the fundamental theory of materials needed for civil engineering projects and unique insights from decades of large-scale construction in China. The title includes the latest advances in new materials and techniques for civil engineering, showing the relationship between composition, structure and properties, and covering ultra-high-performance concrete and self-compacting concrete developed in China. This book provides comprehensive coverage of the most commonly used, most advanced materials for use in civil engineering. This volume consists of eight chapters covering the fundamentals of materials, inorganic cementing materials, Portland cement concrete, bricks, blocks and building mortar, metal, wood, asphalt and polymers.
Machine learning for risk calculations : A practitioner's view
Fundamental Approximation Methods. Machine Learning -- Deep Neural Nets -- Chebyshev Tensors -- The toolkit - plugging in approximation methods. Introduction: why is a toolkit needed -- Composition techniques -- Tensors in TT format and Tensor Extension Algorithms -- Sliding Technique -- The Jacobian projection technique -- Hybrid solutions - approximation methods and the toolkit.
Big Data Science in Finance
Explains the mathematics, theory, and methods of Big Data as applied to finance and investing Examines the mathematics, theory, and practical use of the revolutionary techniques that are transforming the industry. Designed for mathematically-advanced students and discerning financial practitioners alike, this energizing book presents new, cutting-edge content based on world-class research taught in the leading Financial Mathematics and Engineering programs in the world. Marco Avellaneda, a leader in quantitative finance, and quantitative methodology author Irene Aldridge help readers harness the power of Big Data. Provides a complete account of Big Data that includes proofs, step-by-step applications, and code samples Explains the difference between Principal Component Analysis (PCA) and Singular Value Decomposition (SVD) Covers vital topics in the field in a clear, straightforward manner Compares, contrasts, and discusses Big Data and Small Data Includes Cornell University-tested educational materials such as lesson plans, end-of-chapter questions, and downloadable lecture slides
Building with earth : Design and technology of a sustainable architecture
For a number of years, the healthy and environment-friendly building material earth, in common use for thousands of years, has been enjoying increasing popularity, including in industrialized nations. In hot dry and temperate climate zones, earth offers numerous advantages over other materials. Its particular texture and composition also holds great aesthetic appeal.
