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Ondansetron Patches
The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.
Integral waterproofing of concrete structures : Advanced protection technologies of concrete by pore blocking and lining
This book first establishes a background about concrete structures and porosity linked with concrete hydration, then goes on to consider concrete durability problems from the perspective of water penetration including damages from freeze-thaw cycles, alkali silica reactions, and chloride ion penetration. The mechanisms, applications, performances, and limitations of waterproofing technologies including coatings and integral systems are compared. The book also showcases all application methods of crystallization waterproofing materials, including material spray on cured concrete and on fresh concrete, and their addition to concrete mix designs as enhancers or admixtures.
Durability of reinforced concrete structures
Reinforced concrete structures corrode as they age, with significant financial implications, but it is not immediately clear why some are more durable than others. This book looks at the mechanisms for corrosion and how corrosion engineering can be used for these problems to be minimized in future projects. Several different examples of reinforced concrete structures with corrosion problems are described and the various life enhancement solutions considered and applied are discussed. The book includes a chapter on the effectiveness of corrosion monitoring techniques and questions why the reality is at odds with current theory and standards.
Corrosion of Steel in Concrete : Understanding, Investigation and Repair
A guide for designing, constructing and maintaining reinforced concrete structures, such as buildings and bridges which are subject to reinforcement corrosion. It presents the basics of theory and practice in steel corrosion in concrete and reviews the latest research and developments, such as progress on measuring the corrosion threshold for chloride-induced corrosion.
Aging, shaking, and cracking of infrastructures : From mechanics to concrete dams and nuclear structures
Focuses on the safety assessment of existing structures subjected to multi-hazard scenarios through advanced numerical methods. Whereas the focus is on concrete dams and nuclear containment structures, the presented methodologies can also be applied to other large-scale ones. This book is composed of seven sections: Fundamentals: theoretical coverage of solid mechnics, plasticity, fracture mechanics, creep, / seismology, dynamic analysis, probability and statistics / Damage: that can affect concrete structures, such as cracking of concrete, AAR, chloride ingress, and rebar corrosion, / Finite Element: formulation for both linear and nonlinear analysis including stress, heat and fracture mechanics, / Engineering Models: for soil/fluid-structure interaction, uncertainty quantification, probablilistic and random finite element analysis, machine learning, performance based earthquake engineering, ground motion intensity measures, seismic hazard analysis, capacity/fragility functions and damage indeces, / Applications to dams through potential failure mode analyses, risk-informed decision making, deterministic and probabilistic examples, / Applications to nuclear structures through modeling issues, aging management programs, critical review of some analyses, / Other applications and case studies: massive RC structures and bridges, detailed assessment of a nuclear containment structure evaluation for license renewal.
