Influence of tamarind seed gum derivatives on the in vitro performance of gastro-retentive tablets based on hydroxypropylmethylcellulose
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Mazen Rajab, A. Tounsi, Mouhidien Jouma, Reinhard H. H. Neubert, M. Dittgen |
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Die Pharmazie - An International Journal of Pharmaceutical Sciences, Volume 67, Number 11, November 2012, pp. 956-957(2) |
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The in vitro performance of gastro-retentive tablets containing metformin was investigated comprising work of adhesion (W), swelling and drug release. To measure W a method was adapted to apply shear stress horizontally. Tablets based on hydroxypropylmethylcellulose (HPMC) were compared with those containing a fraction of tamarind seed gum (TSG) or its derivatives instead of HPMC. Surprisingly, the TSG as well the derivatives investigated here were lowering W but they were increasing drug release rate and swelling of the tablets. TSG of carboxyl methyl type increased both dissolution and swelling significantly whilst W remained unchanged. |
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