Researchers

Mohamad Ammar Al‐Khayat1, Samer Haidar1, Huda Mando

Published in

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES REVIEW AND RESEARCH, 14 (2), 2012; nᵒ 01, 1-5

Abstract

A Simple, sensitive and specific RP-HPLC method was developed and validated for the determination of clopidogrel in tablets. Isocratic chromatography was performed on a C18 column with acetonitrile-methanol-phosphate buffer 0.1M 80:10:10 (v/v/v) as mobile phase at a flow rate of 0.9 ml/min. UV detection was set at 240 nm. The method was validated with respect to accuracy, linearity, precision, selectivity, and robustness. All the parameters examined met the current recommendations of U.S.P (30) for analytical method validation. The method can be reliably used for routine quality control analysis and to determine the clopidogrel content of marketed tablets.

Keywords: Clopidogrel, RP‐HPLC, Validation.

Link to read full paper

https://www.researchgate.net/publication/282543298_Development_and_validation_of_RP-HPLC_method_for_determination_of_clopidogrel_in_tablets