For many years, colchicine has been used for therapeutic purposes and has been given considerable attention because of its association with tubulin and inhibition of small tubular polymerization. Colchicine is an alkaloids extracted from the colchicum autumnale plant, and it contains a molecular formula C₂₂H₂₅NO₆, and it consists of three rings. Many studies have concerned with structural changes, in order to increase their pharmacological effectiveness and to reduce the side effects of toxicity arising from it. The therapeutic use of colchicine has been mainly documented in Gout, Familial Mediterranean Fever, and many other diseases such as atrial fibrillation and some researchers have been interested in the possibility of using colchicine and its analogs as an anticancer agent. This review summarizes the history of chemical structure of colchicine and presents some of its analogues. Furthermore, it shows binding mechanism with target protein when colchicine is used as a therapeutic drug, and it gives a light spot on some studies that discuss the safe use of colchicine.