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Cilia : Methods and protocols
Covers the latest advancements in the study of ciliary complexity. Protocols cover genomic, proteomic, imaging, and functional analysis of different ciliated tissues and their wide applicability in cilia biology. Chapters in this book primarily focus on methods to study multiciliated cells, and discuss topics such as SARS-CoV-2 infections of human primary nasal multiciliated epithelial cells; expansion microscopy of ciliary proteins; live-imaging centriole amplification in mouse brain multiciliated cells; biophysical properties of cilia motility; and mucociliary transport device construction. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Chemokine biology : Basic research and clinical application ; Vol.1 : Immunobiology of chemokines
The discovery of interleukin-8 close to 20 years ago initiated a new field of research touching on many aspects of immunology and inflammation. Interleukin-8 is just one member of a large class of structurally related chemoattractant proteins, known as chemokines. Chemokines are involved in the traffic control of leukocytes, which bear the corresponding chemokine receptors on their surfaces. Today, it is clear that chemokines affect all aspects of immunology and even many unrelated fields, such as tissue development and tumor cell metastasis. Their fundamental contributions to chronic inflammatory diseases make them a principal target for the development of novel, anti-inflammatory therapeutics.
