Biopharmaceutical manufacturing progress, trends and challenges
- Author
- Ralf Pörtner
- Publication Year
- 2023
- Publisher
- Springer
- Language
- English
- Document Type
- Book
- Faculty / Subject Heading
- Medical Science
- Download Book Read book
Source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation.
Keywords: Biopharmaceuticals / Therapeutic antibodies / Manufacturing / Viral vaccines / Gene therapy / Cell therapy / Up- and downstream / Digital twin / Cell biology / Biomedical engineering / Bioengineering / Biotechnology / Cytology / Pharmaceutical chemistry / Biomaterials / Bioprocess engineering
