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Key Clinical Trials in Erectile Dysfunction
Represents a critical appraisal of the major clinical trials that have had a significant impact on clinical research and practice during the last decade. Each trial follows a strict format, starting with reference to the original source of publication, details on the key investigators and their methods of research. The strengths and weaknesses of each trial are discussed as well as their influence on clinical practice. Articles are complemented by a diagrammatic summary of the trial design and the key findings.
Characterization of Pharmaceutical Nano- and Microsystems
Offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker.
Bioanalytics : Analytical methods and concepts in biochemistry and molecular biology
Analytical methods are the essential enabling tools of the modern biosciences. This book presents a comprehensive introduction into these analytical methods, including their physical and chemical backgrounds, as well as a discussion of the strengths and weakness of each method. It covers all major techniques for the determination and experimental analysis of biological macromolecules, including proteins, carbohydrates, lipids and nucleic acids.
Bacteriocins : Ecology and Evolution
Microbes produce an extraordinary array of defense systems. These include bacteriocins, a class of antimicrobial molecules with narrow killing spectra, produced by bacteria. The book describes the diversity and ecological role of bacteriocins of Gram-positive and Gram-negative bacteria, presenting a new classification scheme for the former and a state-of-the-art look at the role of bacteriocins in bacterial communication. It discusses the molecular evolution of colicins and colicin-like bacteriocins, and provides a contemporary overview of archaeocins, bacteriocin-like antimicrobials produced by archaebacteria. Furthermore, various modeling (in silico) studies elucidate the role of bacteriocins in microbial community dynamics and fitness, delving into rock-paper-scissors competition and the counter-intuitive survival of the weakest. The book makes compelling reading for a multi-faceted scientific audience, including those working in the fields of biodiversity and biotechnology, notably in the human and animal health domain.
Applied biophysics for drug discovery
It is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns.
Beginning VB 2008 : From novice to professional
This book is for anyone who wants to write good Visual Basic 2008 code, even if you have never programmed before. Writing good code can be a challenge, there are so many options, especially in a language like Visual Basic. If you want to really get the best from a programming language you need to know which features work best in which situations and understand their strengths and weaknesses. It is this understanding that makes the difference between coding and coding well.
Beginning C# 2008 : From novice to professional
This book is for anyone who wants to write good C# code—even if you have never programmed before. Writing good code can be a challenge—there are so many options, especially in a .NET language like C#. If you want to really get the best from a programming language, you need to know which features work best in which situations, and understand their strengths and weaknesses. It is this understanding that makes the difference between coding and coding well. Beginning C# 2008: From Novice to Professional, Second Edition has been written to teach you how to use the C# programming language to solve problems. From the earliest chapters and the first introductory concepts, you'll be looking at real–world programming challenges and learning how C# can be used to overcome them.
Anti-fragile ICT Systems
Introduces a novel approach to the design and operation of large ICT systems. It views the technical solutions and their stakeholders as complex adaptive systems and argues that traditional risk analyses cannot predict all future incidents with major impacts. To avoid unacceptable events, it is necessary to establish and operate anti-fragile ICT systems that limit the impact of all incidents, and which learn from small-impact incidents how to function increasingly well in changing environments. The book applies four design principles and one operational principle to achieve anti-fragility for different classes of incidents. It discusses how systems can achieve high availability, prevent malware epidemics, and detect anomalies. Analyses of Netflix’s media streaming solution, Norwegian telecom infrastructures, e-government platforms, and Numenta’s anomaly detection software show that cloud computing is essential to achieving anti-fragility for classes of events with negative impacts.
Abstract Computing Machines : A Lambda Calculus Perspective
The book addresses ways and means of organizing computations, highlighting the relationship between algorithms and the basic mechanisms and runtime structures necessary to execute them using machines. It completely abstracts from concrete programming languages and machine architectures, taking instead the lambda calculus as the basic programming and program execution model to design various abstract machines for its correct implementation. The emphasis is on fully normalizing machines based on full-fledged beta-reductions as essential prerequisites for symbolic computations that treat functions and variables truly as first-class objects. Their weakly normalizing counterparts are shown to be functional abstract machines that sacrifice the flavors of full beta-reductions for decidedly simpler runtime structures and improved runtime efficiency. Further downgrading of the lambda calculus leads to classical imperative machines that permit side-effecting operations on the runtime environment.
Civil engineering structures according to the Eurocodes : Inspection and maintenance
This standard assumes that the structure, after completion, is used as intended in the project and subject to planned inspection and maintenance to meet the expected project lifetime and to detect any unforeseen weakness or behavior" (EN 13670 4.1)An important decision factor in the design of new structures and repairs to existing structures is the lifetime or expected service life. This concept, which is common for civil engineering works, has been extended to all engineering and building works by applying the European Structural Design Codes.
Applied geotechnics for construction projects ; Vol. 1 : Soil and Experimental Data
Applied Geotechnics for Construction Projects 1 first defines, identifies and classifies soils, exploring their complexities and weaknesses, and then outlines the basic principles of stresses and strains that establish and develop within soils. The third chapter of the book introduces and develops methods of soil investigation in order to experimentally determine the geotechnical parameters that are useful in the design stage of construction projects.
Marketing for Sustainable Development : Rethinking Consumption Models
Many people see a weak association between marketing and sustainable development and even consider them as two incompatible fields. However, marketing benefits from an extremely powerful position to encourage transformations at the production level and to guide consumers towards responsible behaviors. From its inception, marketing has been positioned as a support for the relationship between the company and its customers, with the quest for well-being set in the very foundations of the discipline.
Advanced Planning in Fresh Food Industries: Integrating Shelf Life into Production Planning
Production planning in fresh food industries is a challenging task. Although modern Advanced Planning and Scheduling (APS) systems could provide significant support, APS implementation numbers in these industries remain low. Therefore, based on an in-depth analysis of three sample fresh food industries (dairy, fresh and processed meat), the author evaluates what APS systems should offer in order to effectively support production planning and how the leading systems currently handle the most distinguishing characteristic of fresh food industries, the short product shelf life. Starting from the identified weaknesses, customized software solutions for each of the sample industries are proposed that allow to optimize the production of fresh foods with respect to shelf life.
Mathematical Methods in Electro-Magneto-Elasticity
The mechanics of Coupled Fields is a discipline at the edge of modern research connecting Continuum Mechanics with Solid State Physics. It integrates the Mechanics of Continuous Media, Heat Conductivity and the theory of Electromagnetism that are usually studied seperately. For an accurate description of the influence of static and dynamic loadings, high temperatures and strong electromagneticfields in elastic media and constructive installations, a new aproach is required; an approach that has the potential to establish a synergism between the above-mentioned fields. Throughout the book a vast number of problems are considered: two-dimensional problems of electro-magneto-elasticity as well as static and dynamical problems for piecewise homogenous compound piezoelectric plates weakened by cracks and openings. The boundary conditions, the constuctive equations and the mathematical methods for their solution are thoroughly presented, so that the reader can get a clear quantative and qualitative understnding of the phenomena taking place.
Markov Processes, Brownian Motion, and Time Symmetry
The book consists of two parts. Part I,This part introduces strong Markov processes and their potential theory. In particular,it studies Brownian motion, and shows how it generates classical potential theory.Part II, focus on the effects of time reversal, duality, and time-symmetry on potential theory. Certain theorems in Part I are re-proved in Part II under slightly weaker hypotheses. The volume is very useful for people who wish to learn Markov processes but it seems to the reviewer that it is also of great interest to specialists in this area who could derive much stimulus from it. One can be convinced that it will receive wide circulation." (Mathematical Reviews)
Many Body Structure of Strongly Interacting Systems ; Refereed and Selected Contributions from the Symposium "20 Years of Physics at the Mainz Microtron MAMI"
This carefully edited proceedings volume provides an extensive review and analysis of the work carried out over the past 20 years at the Mainz Microtron (MAMI). This research centered around the application of Quantum Chromodynamics in the strictly nonperturbative regime at hadronic scales of about 1 fm. Due to the many degrees of freedom in hadrons at this scale the leitmotiv of this research is "Many body structure of strongly interacting systems". Further, an outlook on the research with the forthcoming upgrade of MAMI is given. This volume is an authoritative source of reference for everyone interested in the field of the electro-weak probing of the structure of hadrons.
Linear Optimization Problems with Inexact Data
Linear programming attracted the interest of mathematicians during and after World War II when the first computers were constructed and methods for solving large linear programming problems were sought in connection with specific practical problems—for example, providing logistical support for the U.S. Armed Forces or modeling national economies. Early attempts to apply linear programming methods to solve practical problems failed to satisfy expectations. There were various reasons for the failure. One of them, which is the central topic of this book, was the inexactness of the data used to create the models. This phenomenon, inherent in most pratical problems, has been dealt with in several ways. At first, linear programming models used "average” values of inherently vague coefficients, but the optimal solutions of these models were not always optimal for the original problem itself. Later researchers developed the stochastic linear programming approach, but this too has its limitations. Recently, interest has been given to linear programming problems with data given as intervals, convex sets and/or fuzzy sets. The individual results of these studies have been promising, but the literature has not presented a unified theory. Linear Optimization Problems with Inexact Data attempts to present a comprehensive treatment of linear optimization with inexact data, summarizing existing results and presenting new ones within a unifying framework.
Bioethics in Cultural Contexts : Reflections on Methods and Finitude
This book discusses a range of methodological issues for an interdisciplinary bioethics. How can bioethics be an enterprise that does not only isolate issues and moral reasons but also (re)contextualises them? What are the strengths and weaknesses of different traditional and innovative modes of ethical work in terms of these tasks?
Axiom of Choice
AC, the axiom of choice, because of its non-constructive character, is the most controversial mathematical axiom, shunned by some, used indiscriminately by others. This treatise shows paradigmatically that:Disasters happen without AC: Many fundamental mathematical results fail (being equivalent in ZF to AC or to some weak form of AC).Disasters happen with AC: Many undesirable mathematical monsters are being created (e.g., non measurable sets and undeterminate games).Illuminating examples are drawn from diverse areas of mathematics, particularly from general topology, but also from algebra, order theory, elementary analysis, measure theory, game theory, and graph theory.
An introduction to relativistic processes and the standard model of electroweak interactions
The first part of the volume is devoted to the description of scattering processes in the context of relativistic quantum field theory. The use of the semi-classical approximation allows us to illustrate the relevant computation techniques in a reasonably small amount of space. Our approach to relativistic processes is original in many respects. The second part contains a detailed description of the construction of the standard model of electroweak interactions, with special attention to the mechanism of particle mass generation. The extension of the standard model to include neutrino masses is also described. We have included a number of detailed computations of cross sections and decay rates of pedagogical and phenomenological relevance.
