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Proteomics and Protein-Protein Interactions : Biology, Chemistry, Bioinformatics, and Drug Design
Techniques have been developed to rapidly create protein-protein interactions maps which in turn can be organized into pathways. Proteins serving as hubs in these networks seem to play crucial biological roles. Some of these proteins may provide new pharmalogical targets for an industry which is rapidly running out of the more classical means of finding new markets. Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, and Drug Design aims at providing a comprehensive yet entertaining view of this rapidly evolving and exciting field. It starts with an overview of the importance of protein-protein interaction in biology (Chapter I). Next, the book dives into Proteomics issues (Chapter II) and describes successful applications of the Proteomics approach. Chapter III focuses on the very specific roles that protein modules play in determining and regulating protein-protein interactions while chapter IV addresses the chemical and energetic underpinnings of such macromolecular interactions. The data generated by a Proteomics approach is abundant and will only be made sense of using bio-informatics: chapter V is dedicated to giving a voice to some of the leaders in the bio-informatics field. Finally, in chapter VI, examples are provided to illustrate the great potential that protein-protein interfaces have as targets for pharmaceutical
Protein-Protein Interactions as New Drug Targets
This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
Protein - Protein Interaction
This book covers trends in modern biotechnology. It treats all aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science
Data Mining for Biomedical Applications ; PAKDD 2006 Workshop, BioDM 2006, Singapore, April 9, 2006, Proceedings
This book constitutes the refereed proceedings of the International Workshop on Data Mining for Biomedical Applications, BioDM 2006, held in Singapore in conjunction with the 10th Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD 2006). The 14 revised full papers presented together with 1 keynote talks were carefully reviewed and selected from 35 submissions. The papers are organized in topical sections on protein-protein interactions, database and search, bio data clustering, and in-silico diagnosis.
Cyclized Helical Peptides : Synthesis, Properties and Therapeutic Applications
Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity
Coronaviruses : Methods and Protocols
Aims to describe a variety of techniques that reflects the wide range of research currently performed in the field of coronavirology, and begins with an overview of current understandings of coronavirus replication and pathogenesis to introduce specialists and non-specialists to the field. The rest of the book is divided into several sections of chapters beginning with those that describe identification, diagnosis, and study of the evolution of coronaviruses. The next few chapters discuss the preparation of cells and organ cultures useful in propagating coronaviruses and titration techniques, as well as techniques for analyzing virus functions that require purification of the viruses. The next chapters describe two commonly used reverse genetics techniques for coronaviruses, and techniques detailing identification of cellular receptors, binding profiles of viral attachment proteins, and virus-cell fusion. The final chapters cover a broad spectrum of techniques to identify virus-host protein-protein interactions, confirm the functional role of these proteins in virus replication, study host cell responses through genome-wide or pathway-specific approaches, and visualize virus replication complexes. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
Chaperones
Molecular chaperones interact with virtually every newly synthesized protein. Their role is not limited to this, as an increasing number of protein-protein interactions are found to be mediated by molecular chaperones. They reside in large complexes, in every cellular compartment, and to some extent even outside cells. These proteins are of interest to a large number of scientists, not only to those interested in protein biosynthesis, but also in relation to protein transport, organelle biogenesis, and cell stress.
Biophotonics ; Optical science and engineering for the 21st century
Biophotonics: Optical Science and Engineering in the 21st Century serves as an ideal aid to the research and development of these areas integrating light, photonics, and biological systems.Key topics include: Fluctuation Correlation Spectroscopy in Cells: Determination of Molecular Aggregation ,Using GFP and FRET Technologies for Studying Signaling Mechanisms of Apoptosis in a Single Living Cell, Study on Protein-Protein Interaction in Single Living Cells, Functional Optical Coherence Tomography: Simultaneous In Vivo Imaging of Tissue Structure and Physiology, Imaging –Photo- and Sonodynamic Diagnosis of Cancer Mediated by Chemiluminescence Probes, Biophotonic Analysis of Spontaneous Self-Organizing Oxidative Processes in Aqueous Systems, Biophoton Emission and Defense Systems in Plants
Bacterial secretion systems : Methods and protocols
Cover techniques used to study secretion systems. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as using reporters to follow effector transport. Written in the highly
