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Clinical metabolomics applications in genetic diseases
Helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. Covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms.
Chemogenomics : Methods and protocols
Presents both theoretical guidance and protocols on chemogenomics including chemogenomics library assembly, compound profiling, and phenotypic assays. The chapters in this book cover topics such as the assembly and use of Kinase Chemogenomics; data mining for chemogenomic compound candidates; protocols for protein family-focused assay systems to profile chemogenomic compounds; functional and target engagement assays in cellular settings for broad characterization; and a discussion on phenotypic assays where chemogenomic sets may be applied.
Carcinoma della cervice uterina : Eziopatogenesi e profilassi = Carcinoma of the uterine cervix : Aetiopathogenesis and prophylaxis
The volume offers a synthetic and updated picture of a complex topic that includes the multifactorial etiopathogenesis of cervical cancer, the characteristics of the virus, the dynamics of HPV infections, the histological lesions of the cervix leading to cervical cancer. and the characteristics of the various surgical treatments, the current strategies for early diagnosis through the use of molecular assays currently on the market, up to the trials of the two vaccines recently registered also in Italy.
Cancer Proteomics : From Bench to Bedside
the authors collectively provide the current status of proteomics in cancer therapy and offers the existing technologies used in proteomics that allow for protein profiling and for the identification of druggable targets in human samples. Mass spectrometry based protein characterization and protein microarrays hold great promise of predicting response to specific drugs in cancer therapy. Insightful to the reader with broad perspectives on topics related to the use of proteomic strategies in cancer therapy, Cancer Proteomics offers anticipated challenges that may arise from its application in daily practice.
Brain Repair
Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics.
Biological invaders in inland waters : Profiles, distribution, and threats
The book examines the identity, distribution, and impact of freshwater non-indigenous species and the dynamics of their invasion. Rather than providing a broad and comprehensive review of the issue, Biological invaders in inland waters focuses on old and new invaders and also raises questions and opens perspectives that provide a starting point for further research. The ultimate purpose of this book is to help define a more general framework for our knowledge of invasions in fresh waters. Such a framework will be indispensable to the planning of a science-based management program.
Basic principles of drug discovery and development ; 2nd ed.
Presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields.
Antidiabetic plants for drug discovery pharmacology, secondary metabolite profiling, and ingredients with insulin mimetic activity
Takes an in-depth look at the potential pharmacological applications of 11 important antidiabetic plants, examining their antihyperglycemic, hypoglycemic, and anti-lipidemic properties along with current genome editing research perspectives. Plant natural products, or phytoconstituents, are promising candidates for antidiabetic pharmacological actions. The phytoconstituents, such as fl avonoids, terpenoids, saponins, carotenoids, alkaloids and glycosides, play vital roles in the current and future potent antidiabetic drug development programs. Each chapter reviews a particular plant with antidiabetic properties, explaining the therapeutic aspects, its active antidiabetic compounds, and relevant genome editing technology.
Analyse céphalométrique fonctionnelle et esthétique de profil = Functional and aesthetic cephalometric profile analysis
The complexity of the craniofacial architecture explains the multiplicity of cephalometric analyzes, too often based on points without phylogenetic, ontogenetic, anatomical or biomechanical justification. The value of a reliable and rapid analysis designed from indisputable fundamental foundations is essential. It enables the use of cephalometry in the daily practice of orthodontists, maxillofacial surgeons and facial plastic surgeons. This functional and aesthetic cephalometric analysis is carried out from fourteen anatomical points, ten bony points and four skin points, which all have in common that they are exo-basicranial. This analysis is easy to understand and use. It only takes five minutes to be learned and five minutes to be traced (fifteen seconds if it is computerized). The resulting results are reliable. The functional and aesthetic analysis is developed through four chapters. The first is devoted to the fundamental bases, the second to the analysis itself and to clinical cases, the third to the comparative study of different cephalometric analyzes, and finally the fourth chapter revisits the work of Arne Björk.
Advanced chemical biology : chemical dissection and reprogramming of biological systems
Organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
An introduction to law
this book addresses the ways in which rules and the structures of law respond to and impact upon changes in economic and political life. The title has been extensively updated and explores recent high profile developments such as the Civil Partnership Act 2005 and the Racial and Religious Hatred Bill.
Beginning Joomla! : From novice to professional
Beginning Joomla! answers many of the questions you're sure to have, guiding you through the process of creating your own design templates, adding and managing content, and adding popular community features such as article commenting, user profile management, and forums.
Advanced Techniques in Knowledge Discovery and Data Mining
This explosion is a result of the growing use of electronic media. But what is data mining (DM)? A Web search using the Google search engine retrieves many (really many) definitions of data mining. We include here a few interesting ones. One of the simpler definitions is: “As the term suggests, data mining is the analysis of data to establish relationships and identify patterns” [1]. It focuses on identifying relations in data. Our next example is more elaborate: An information extraction activity whose goal is to discover hidden facts contained in databases. Using a combination of machine learning, statistical analysis, modeling techniques and database technology, data mining finds patterns and subtle relationships in data and infers rules that allow the prediction of future results. Typical applications include market segmentation, customer profiling, fraud detection, evaluation of retail promotions, and credit risk analysis .
Advanced Algorithms and Data Structures
introduces a collection of algorithms for complex programming challenges in data analysis, machine learning, and graph computing. You’ll discover cutting-edge approaches to a variety of tricky scenarios. You’ll even learn to design your own data structures for projects that require a custom solution. What's inside Build on basic data structures you already know Profile your algorithms to speed up application Store and query strings efficiently Distribute clustering algorithms with MapReduce Solve logistics problems using graphs and optimization algorithms
Adult Orthodontics
An authoritative resource on the subject of adult orthodontics, marrying together clinical guidance with a thorough evaluation of the evidence base. Sample topics discussed within the book include: Context for adult orthodontics, including patient demographics and aetiologyTreatment planning considerations, including patient case profiles, initial outcomes and longer-term expectationsInterdisciplinary and multidisciplinary approaches, including the links between adult orthodontics and periodontics, prosthetics, and temporomandibular disorders
Managing Information Systems Security and Privacy
The book deals with the management of information systems security and privacy, based on a model that covers technological, organizational and legal views. This is the basis for a focused and methodologically structured approach that presents "the big picture" of information systems security and privacy, while targeting managers and technical profiles. The book addresses principles in the background, regardless of a particular technology or organization. It enables a reader to suit these principles to an organization's needs and to implement them accordingly by using explicit procedures from the book. Additionally, the content is aligned with relevant standards and the latest trends.
Behavioral finance and your portfolio : A navigation guide for building wealth
Designed for investors who are serious about maximizing their gains, in this book you’ll discover how to: ● Take control of your decision-making—even when challenging markets push greed and fear to intolerable levels ● Reflect on how to make investment decisions using data-backed and substantiated information instead of emotion and bias ● Counter deep-seated biases like loss aversion, hindsight and overconfidence with self-awareness and hard facts ● Identify your personal investment psychology profile, which you can use to inform your future financial decision making
AI in marketing, sales and service : How marketers without a data science degree can use AI, big data and bots
Shows you: how customer and market potential can be automatically identified and profiled; how media planning can be intelligently automated and optimized with AI and Big Data; how (chat)bots and digital assistants can make communication between companies and consumers more efficient and smarter; how you can optimize Customer Journeys based on Algorithmics and AI; and how to conduct market research in more efficient and smarter way.
Architecture beyond the cupola : Inventions and designs of Dante Bini
This book reviews Dante Bini’s inventions and designs, focusing on his form-resistant Binishell and other pneumatic construction systems. Dante Bini’s double profile of architect and builder underpins the narrative of the entire book. It is used to analyse the evolution of the early reinforced-concrete Binishell patent into a variety of automated construction systems based on the use of air. Dante Bini has always been quite proactive in promoting his work and disseminating the results of his experimentations and achievements via journal articles, conference presentations and public talks.
