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Theory and Mathematical Methods for Bioformatics
This monograph addresses, in a systematic and pedagogical manner, the mathematical methods and the algorithms required to deal with the molecularly based problems of bioinformatics. The book will be useful to students, research scientists and practitioners of bioinformatics and related fields, especially those who are interested in the underlying mathematical methods and theory. Among the methods presented in the book, prominent attention is given to pair-wise and multiple sequence alignment algorithms, stochastic models of mutations, modulus structure theory and protein configuration analysis. Strong links to the molecular structures of proteins, DNA and other biomolecules and their analyses are developed. In particular, for proteins an in-depth exposition of secondary structure prediction methods should be a valuable tool in both molecular biology and in applications to rational drug design. The book can also be used as a textbook and for this reason most of the chapters include exercises and problems at the level of a graduate program in bioinformatics.
Ryanodine Receptors : Structure, function and dysfunction in clinical disease
In recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor. "In this series of brief but informative chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology."
Microtectonics
The book mainly focusses on optical microscopy as a tool to study microstructures, but also describes other techniques such as EBSD and tomography. Many photographs and explanatory drawings clarify the text. Newest developments in microtectonics have been included in all chapters so that al chapters have been revised and updated, e.g. new information on brittle microstructures. Two new chapters have been added, on primary structures and experimental microstructures. Chapters on veins, shear zones, natural microgauges experimental modelling techniques and alternative techniques have been completely renewed
Biomacromolecules : Carbohydrates, lipids, proteins and nucleic acids
The first chapter looks at the structural formulas and cyclic forms of monosaccharides, as well as their synthesis and breakdown. Cyclization, enolization, isomerization, tautomerization, mutarotation, and epimerization are all briefly described. Examples of disaccharides and polysaccharides are also presented. The second chapter covers triglycerides, steroids, vitamins, and their constituents. The third chapter examines the primary structure of proteins, including amino acid properties, peptide bond formation, and peptide synthesis. It also addresses secondary, tertiary, and quaternary structures. The book concludes with a chapter on nucleic acids, which covers the chemistry of nucleosides and oligonucleotides as well as topics such as genetic code, DNA secret code, Polymerase Chain Reaction and DNA fingerprinting.
