Solid self micro emulsifying drug delivery system

Explores the formulation of Solid Self-Microemulsifying Drug Delivery Systems (SSMEDDS) as a strategy to enhance oral bioavailability and reduce GI side effects of NSAIDs. Tiaprofenic acid, a poorly soluble acidic NSAID, was selected as a model drug to develop and evaluate the delivery system. Excipients were selected using Hansen solubility parameters. While castor oil showed optimal solubility, it was excluded due to known irritancy. Olive oil was chosen for its adequate solubilization capacity and documented gastric protective effects. The optimized SMEDDS formulation was solidified via adsorption on Aerosil.