Page 1
Page 1
شركة هندسية : Scaffolding Company
الهدف من المشروع هو عدم وجود مركز رسمي أو غير رسمي يخدم الشركة في المنطقة من حيث التصميم والتنفيذ.
Weak Links : The Universal Key to the Stability of Networks and Complex Systems
How can our societies be stabilized in a crisis? Why can we enjoy and understand Shakespeare? Why are fruitflies uniform? How do omnivorous eating habits aid our survival? What makes the Mona Lisa’s smile beautiful? How do women keep our social structures intact? – Could there possibly be a single answer to all these questions? This book shows that the statement: "weak links stabilize complex systems" provides the key to understanding each of these intriguing puzzles, and many others too. The author (recipient of several distinguished science communication prizes) uses weak (low affinity, low probability) interactions as a thread to introduce a vast variety of networks from proteins to economics and ecosystems.
Unfoldings : A Partial-Order Approach to Model Checking
In this book the authors introduce unfoldings, an approach to model checking which alleviates the state explosion problem by means of concurrency theory. They offer a gentle introduction to the basics of the method, and in particular they detail an unfolding-based algorithm for model checking concurrent systems against properties specified as formulas of linear temporal logic (LTL). Self-contained chapters cover transition systems and their products; unfolding products; search procedures for basic verification problems, such as reachability and livelocks; and model checking LTL.
Unfolding Social Constructionism
This book examines social constructionism as a metatheory of psychology. It does not consider constructionist accounts of psycho-social phenomena, but it does assess certain assumptions which are said to underpin those accounts, assumptions which are primarily semantic and epistemological.
Understanding Cities : Method in Urban Design
Creates the vital link between urban design theory and praxis and opens the required methodological gateway to a new and unified field of urban design. Using spatial political economy as his most important reference point, Alexander Cuthbert both interrogates and challenges mainstream urban design and provides an alternative and viable comprehensive framework for a new synthesis. He rejects the idea of yet another theory in urban design, and chooses instead to construct the necessary intellectual and conceptual scaffolding for what he terms 'The New Urban Design'. Building both on Michel de Certeau's concept of heterology – 'thinking about thinking' – and on the framework of his previous books Designing Cities and The Form of Cities, Cuthbert uses his prior adopted framework – history, philosophy, politics, culture, gender, environment, aesthetics, typologies and pragmatics – to create three integrated texts.
Transmembrane β-barrel proteins : Methods and protocols
Explores experimental strategies and protocols for the expression, assembly, characterization, and exploitation of transmembrane β-barrel proteins. Beginning with methodologies to study their assembly, the book continues with protocols for characterizing the landscape of transmembrane β-barrel protein interactions with other cellular factors, dissecting processes of protein transport in bacteria and mitochondria, examining structural characterization, determination, and prediction, and more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Transactions on Petri Nets and Other Models of Concurrency I
It contains teaching concurrency; process languages; process mining; software engineering; state space visualisation techniques; timed Petri nets; unfolding techniques and hardware systems. Thus, this volume gives a good overview of the state of the art in concurrency research.
Science Literacy in Primary Schools and Pre-Schools
Presents the state-of-the-art in science education for kindergarten and primary schools. It begins with a thorough theoretical discussion on why it is incumbent on the science educator to teach science already at first stages of childhood. It goes on to analyze and synthesize a broad range of educational approaches and themes such as: inquiry-based teaching; learning through authentic problems; scaffolding; situated learning; learning through projects; non-verbal knowledge; and informal learning. The book also presents fresh novel strategies to science teaching such as learning science through designing, building, evaluating and redesigning simple artifacts; and Inquiry Events.
Rugged Free Energy Landscapes : Common Computational Approaches to Spin Glasses, Structural Glasses and Biological Macromolecules
This collection of lectures and tutorial reviews by renowned experts focusses on the common computational approaches in use to unravel the static and dynamical behaviour of complex physical systems at the interface of physics, chemistry and biology. Paradigmatic examples of condensed matter physics are spin and structural glasses and protein folding, as well as their aggregation and adsorption to hard and soft surfaces, in physico-chemical biology.
RNA folding : Methods and protocols
Discusses the various levels of prediction and algorithmic approaches to RNA folding. The chapters in this book cover topics such as energy parameters of the nearest-neighbor (NN) energy model; classified dynamic programming to address exponential growth of candidate structures that an RNA molecule may fold into; sequence evolution and conserved structures among multiple RNA sequences; the latest framework capable of handling both positive and negative RNA sequence design objectives; and kinetic folding approaches that look at the dynamic nature of RNA folding
Reviews of Physiology, Biochemistry and Pharmacology
Virus proliferation depends on the successful recruitment of host cellular components for their own replication, protein synthesis, and virion assembly. In the course of virus particle production a large number of proteins are synthesized in a relatively short time, whereby protein folding can become a limiting step. Most viruses therefore need cellular chaperones during their life cycle. In addition to their own protein folding problems viruses need to interfere with cellular processes such as signal transduction, cell cycle regulation and induction of apoptosis in order to create a favorable environment for their proliferation and to avoid premature cell death. Chaperones are involved in the control of these cellular processes and some viruses reprogram their host cell by interacting with them. Hsp70 chaperones, as central components of the cellular chaperone network, are frequently recruited by viruses. This review focuses on the function of Hsp70 chaperones at the different stages of the viral life cycle emphasizing mechanistic aspects
Reviews in Fluorescence 2005
It summarizes the year’s progress in fluorescence, with authoritative analytical reviews specialized enough to be attractive to professional researchers, yet also appealing to the wider audience of scientists in related disciplines of fluorescence. Reviews in Fluorescence 2005 topics include: - RNA folding and RNA-protein binding analyzed using fluorescence. / Progress in Lanthanides as luminescent probes. / The combined use of fluorescence spectroscopy and X-Ray crystallography to elucidating structure and dynamics of proteins. / Tapered fibers for cell studies. / Fluorescence-based ophthalmic glucose monitoring for diabetics. / High-throughput tissue image cytometry. / DNA condensation using FCS. / Multidimensional TCSPC.
Protein-Protein Interactions as New Drug Targets
This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
Protein Misfolding, Aggregation and Conformational Diseases ; Part B : Molecular Mechanisms of Conformational Diseases
This volume summarizes recent achievements in the understanding of the molecular mechanisms of conformational diseases. Research indicates that these mechanisms are highly diverse and range from the altered protein structure leading to the enhanced propensity for aggregation/deposition or the impaired functions and ending with changes in supra-molecular structures or posttranslational modification.
Protein misfolding, aggregation and conformational diseases ; Part A : Protein aggregation and conformational diseases
Protein Misfolding, Aggregation, and Conformational Disease, is the first book to discuss significant achievements in protein structure-function relationships in the areas of biochemistry, molecular biology and molecular medicine. This volume summarizes recent achievements in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.
Protein Folding Kinetics : Biophysical Methods
The book gives a deep insight into the principles and concepts of the kinetic and structural resolution of fast chemical and biophysical reactions of proteins with emphasis on protein-folding reactions. The study of fast protein-folding reactions and the understanding of the folding paradox have significantly advanced due to the recent development of new biophysical methods which allow not only kinetic resolution in the sub-millisecond time scale but also structural resolution with unprecedented precision.
Phenomenology of Life. Meeting the Challenges of the Present-Day World
Philosophy has been always received or bypassed for its resonance or aloofness with the spirit of the time. Should not philosophy/phenomenology of life be expected to do more to ascertain its validity? Should it not pass the pragmatic test, that is to respond directly to the life-concerns of its time? What is the role of the philosopher and philosophy today? Due to the ever-advancing scientific, technological, social and cultural changes that are shaping human life and the life-world-in-transformation, we are desperately seeking a measure to estimate life's unfolding, a compass to stir the course between Scylla and Charibda to maintain human-hood and creative insight for laying the cornerstones for the unforeseeable unfolding of life dynamisms. It is this challenge which philosophy/phenomenology of life meets with underlying ontopoietic unraveling of the hidden logoic concatenations of beingness-in-becoming.
New Algorithms for Macromolecular Simulation
Molecular simulation is a widely used tool in biology, chemistry, physics and engineering. This book contains a collection of articles by leading researchers who are developing new methods for molecular modelling and simulation. Topics addressed here include: multiscale formulations for biomolecular modelling, such as quantum-classical methods and advanced solvation techniques; protein folding methods and schemes for sampling complex landscapes; membrane simulations; free energy calculation; and techniques for improving ergodicity. The book is meant to be useful for practitioners in the simulation community and for those new to molecular simulation who require a broad introduction to the state of the art.
Molecular Chaperones in Health and Disease
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
Modern Multidimensional Scalin : Theory and Applications
The book provides a comprehensive treatment of multidimensional scaling (MDS), a family of statistical techniques for analyzing the structure of (dis)similarity data. This book may be used as an introduction to MDS for students in psychology, sociology, and marketing. The prerequisite is an elementary background in statistics. The book is also well suited for a variety of advanced courses on MDS topics. All the mathematics required for more advanced topics is developed systematically. This second edition adds some 140 pages of new material. Many chapters are revised or have sections reflecting new insights and developments in MDS. There are two new chapters, one on asymmetric models and the other on unfolding. There are also numerous exercises that help the reader to practice what he or she has learned, and to delve deeper into the models and its intricacies.
