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Ion channels as targets in drug discovery
Built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience
Innovative Perspectives in Oral and Maxillofacial Surgery
Examines the latest technologies and developments in oral and maxillofacial surgery. Extensive and unique, Innovative Perspectives in Oral and Maxillofacial Surgery is a vital tool for all dental specialists ranging from undergraduate students to established oral maxillofacial surgeons.
In Vivo Models of Inflammation ; Vol. II
In Vivo Models of Inflammation (Vol. 2) provides biomedical researchers in both the pharmaceutical industry and academia with a description of the state-of-the-art animal model systems used to emulate diseases with components of inflammation.
In Vivo Models of Inflammation ; Vol. I
In Vivo Models of Inflammation (Vol. 1) provides biomedical researchers in both the pharmaceutical industry and academia with a description of the state-of-the-art animal model systems used to emulate diseases with components of inflammation.
Gambling Problems in Youth : Theoretical and Applied Perspectives
Howard J. Shaffer, Ph. D. More than 20 years ago, I first noted that young people in North America were growing up in a context of legalized gambling for their entire lifetime. By the 1980s, for young people, gambling had become an average and expectable part of the social landscape. Amid legal opportunities to gamble in all but two of the United States and with illicit opportunities to gamble in every state, gambling is now ubiquitous in America. With few social sa- tions to limit a young person’s interest in gambling—like their adult co- terparts—young people now gamble in larger numbers and for seemingly higher stakes
Entrepreneurship Policy : Theory and Practice
Entrepreneurship Policy: Theory and Practice is the first book to fully analyze the construction of entrepreneurship policy, a rapidly-evolving area of policy about which little is known. From a study and assessment of the practices of governments in thirteen countries in Europe, North America and the Asia-Pacific region, this book fully describes the policy area and shares new tools and methods for better understanding and explaining the how and why of an entrepreneurship policy approach. Methods of note include the entrepreneurship policy comprehensiveness index and the context method. It presents a conceptual model describing the many factors which affect, in a dynamic way, the level of entrepreneurship in a country or region. It also describes a typology of entrepreneurship policy which will be useful to others in categorizing their policy approaches.
Drug and Biological Development : From Molecule to Product and Beyond
Drug and Biological Development: From Molecule to Product and Beyond offers a complete discussion of product development in the pharmaceutical and biotechnology industries from discovery to product launch, continuing through life cycle management. The book is organized for optimal usefulness in the education and training of health care professionals. The text's narrative descriptions are enhanced by real-life examples, illustrations, controversies in industry, and references. Dr. Ronald Evens and his contributors are industry and research experts in a variety of disciplines.
Data assimilation fundamentals : A unified formulation of the state and parameter estimation problem
This textbook's significant contribution is the unified derivation of data-assimilation techniques from a common fundamental and optimal starting point, namely Bayes' theorem. Unique for this book is the "top-down" derivation of the assimilation methods. It starts from Bayes theorem and gradually introduces the assumptions and approximations needed to arrive at today's popular data-assimilation methods. This strategy is the opposite of most textbooks and reviews on data assimilation that typically take a bottom-up approach to derive a particular assimilation method.
Data Assimilation : The Ensemble Kalman Filter
Data Assimilation comprehensively covers data assimilation and inverse methods, including both traditional state estimation and parameter estimation. This text and reference focuses on various popular data assimilation methods, such as weak and strong constraint variational methods and ensemble filters and smoothers. It is demonstrated how the different methods can be derived from a common theoretical basis, as well as how they differ and/or are related to each other, and which properties characterize them, using several examples.It presents the mathematical framework and derivations in a way which is common for any discipline where dynamics is merged with measurements. The mathematics level is modest, although it requires knowledge of basic spatial statistics, Bayesian statistics, and calculus of variations. Readers will also appreciate the introduction to the mathematical methods used and detailed derivations, which should be easy to follow, are given throughout the book. The codes used in several of the data assimilation experiments are available on a web page.The focus on ensemble methods, such as the ensemble Kalman filter and smoother, also makes it a solid reference to the derivation, implementation and application of such techniques. Much new material, in particular related to the formulation and solution of combined parameter and state estimation problems and the general properties of the ensemble algorithms, is available here for the first time.
Lentil : An ancient crop for modern times
Presents the most comprehensive and up to date review of research on lentil production systems, biotic and abiotic stresses management, quality seed production, storage techniques and lentil growing around the world. This book will be of great value to legume breeders, scientists, nutritionists, academic
Complex dental implant complications
This book offers up-to-date guidance in the diagnosis and management of the various complex complications that may be encountered during or after the placement of dental implants. The aim is to raise the awareness of clinicians regarding such complications and to equip them with the knowledge needed in order to deal with complications promptly and effectively.
Community Quality-of-Life Indicators : Best Cases VIII
Offers critical insights into the thriving international field of community indicators, incorporating the experiences of government leaders, philanthropic professionals, community planners and a wide range of academic disciplines. It illuminates the important role of community indicators in diverse settings and the rationale for the development and implementation of these innovative projects. details many of the practical “how to” aspects of the field as well as lessons learned from implementing indicators in practice. The case studies included here also demonstrate how, using a variety of data applications, leaders of today are monitoring and measuring progress and communities are empowered to make sustainable improvements in their wellbeing.
Advances in Algal Biology : A Commemoration of the Work of Rex Lowe
Advances in Algal Biology: A Commemoration of the Work of Rex Lowe was written by students and colleagues of Rex Lowe to acknowledge his esteemed career that included exceptional contributions to research and teaching. Papers in the book cover a variety of topics in algal ecology, focusing on benthic algal ecology in freshwater ecosystems. The studies provide an unusual combination of small-scale experiments and large-scale regional surveys that bridge both basic and applied ecology. Ecologists, limnologists, phycologists, and environmental scientists will find valuable contributions to the development and application of algal research.
